Category: 40283-46-3

In an article, published in an article, once mentioned the application of 40283-46-3, Name is 2-Aminothiazole-5-carboxylic acid,molecular formula is C4H4N2O2S, is a conventional compound. this article was the specific content is as follows.Safety of 2-Aminothiazole-5-carboxylic acid

Cancer is a second leading cause of death after heart attack, in developing as well as undeveloped countries. It is caused by unregulated growth and metastasis of the abnormal cancer cells. Cancer can be cured by radiation, immunotherapy and chemotherapy, among them; chemotherapy is a good treatment for cancer, in which chemotherapeutic drug is used. The anticancer activity of newly synthesized compounds (13a-j) was carried out on four different types of human cancer cell lines like MCF-7 (breast), A549 (lung), Colo-205 (colon) and A2780 (ovarian) by the MTT method, and compared to etoposide used as a positive control. Among them, compound 13g with electron-withdrawing (3,5-dinitro) group, exhibited more promising activity in all cell lines (MCF-7 = 0.10±0.076 muM, A549 = 0.17±0.039 muM, Colo-205= 0.13±0.022 muM and A2780 = 0.87±0.027muM). This compound may act as lead drug in cancer chemotherapy. In future, this compound can be examined for clinical studies.

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Reference：
Thiazole | C3H2328NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 40283-46-3. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 40283-46-3, Name is 2-Aminothiazole-5-carboxylic acid. In a document type is Article, introducing its new discovery.

The rate constants of the decarboxylation reaction of 2-amino- and 2-phenylamino-thiazole-5-carboxylic acid (3a-b), and, for comparison, of 5-phenylamino-1,3,4-thiadiazole-2-carboxylic acid (2b) have been measured in water over a range of proton activities.The results obtained suggest: (i) compound 2b decarboxylates, in the whole range of proton activity studied, through a unimolecular decarboxyprotonation mechanism characteristic of 1,3,4-oxa- and 1,3,4-thiadiazole derivatives; (ii) in contrast, 3a-b decarboxylate via either a unimolecular decarboxyprotonation or a bimolecular protiodecarboxylation mechanism as a function of proton activity.

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Reference：
Thiazole | C3H2321NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 40283-46-3, Name is 2-Aminothiazole-5-carboxylic acid,molecular formula is C4H4N2O2S, is a conventional compound. this article was the specific content is as follows.Application In Synthesis of 2-Aminothiazole-5-carboxylic acid

One kind has azo thiazole structure suitable for supercritical carbon dioxide water-free wool dyeing of the disperse dye and its preparation method (by machine translation)

The invention provides a with azo thiazole structure suitable for supercritical carbon dioxide water-free wool dyeing of the disperse dye, preparation method thereof and dyeing method, the dye, having the general formula I of the structure. The dye can be used in the supercritical carbon dioxide water-free wool dyeing, such compound in the supercritical carbon dioxide has a certain level of solubility, while at the same time utilize active group and wool in the amino or hydroxy group of the chemical reaction, the reaction product to the supercritical carbon dioxide dyeing device non-corrosiveness. In the general formula I: m, n each is an integer; X, Y are independently selected from one of – H, – CN, – CH3 O, – COOCH3 or R0 R is selected from1 , R2 Or R3 ; Ar Ar selected from1 ; (by machine translation)

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Reference：
Thiazole | C3H2324NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 40283-46-3, Name is 2-Aminothiazole-5-carboxylic acid, Safety of 2-Aminothiazole-5-carboxylic acid.

The present disclosure relates to novel compounds and pharmaceutical compositions thereof which are useful as inhibitors of proteasomes. The compounds provided herein are capable of inhibiting all three of CT-L, T-L, and PGPH activities of proteasomes, and are useful in treating various conditions or diseases associated with proteasomes.

The present disclosure relates to novel compounds and pharmaceutical compositions thereof which are useful as inhibitors of proteasomes. The compounds provided herein are capable of inhibiting all three of CT-L, T-L, and PGPH activities of proteasomes, and are useful in treating various conditions or diseases associated with proteasomes.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Safety of 2-Aminothiazole-5-carboxylic acid. In my other articles, you can also check out more blogs about 40283-46-3

Reference£º
Thiazole | C3H2323NS – PubChem,
Thiazole | chemical compound | Britannica

40283-46-3, 2-Aminothiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 14: 2-(tert-Butoxycarbonylamino)thiazole-5-carboxylic acid BocHN [0111] A mixture of 2-aminothiazole-5-carboxylic acid (2.2 kg, 15.33 mol), aqueous 2 M NaOH (0.674 kg in 8.39 L of DI water), DI water (17.68 L), and THF (17.68 L) was cooled to about 0C. A solution of Boc-anhydride (4.02 kg, 1.20 equiv) in THF (2.21 L) was added to the mixture while maintaining an internal temperature below 5C. When the addition was complete, the reaction mixture was warmed to an internal temperature of 25C and was stirred for 24 hours. The reaction mixture was cooled to about 0C and diluted with DI water (22.1 L). While maintaining an internal temperature below 5C, the pH of the mixture was adjusted to 4.9 by slowly adding acetic acid (5.30 L). After 1 hour a precipitate formed, which was collected by filtration, and rinsed successively with DI water (6.63 L) and MTBE (4.42 L). The filter cake was held under nitrogen for 1 hour and then dried under reduced pressure at 25C to afford the title compound (5.14 kg).

40283-46-3, The synthetic route of 40283-46-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; MATTHEWS, Christopher; O’BRYAN, Colin; PROVENCAL, David Paul; WO2012/51450; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica