Category: 4146-24-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4146-24-1,6-Chloro-2-methylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.,4146-24-1

Step (iv): 2-(Bromomethyl)-6-chloro-l,3-benzothiazole To the solution of 6-chloro-2-methyl-l,3-benzothiazole (15 g, 81.96 mmol) in carbon tetrachloride (500 ml) was added benzoyl peroxide (0.92 g, 0.364 mmol) and N- bromosuccinimide (18.52 g, 10.40 mmol) and the resulting mixture was stirred at reflux for 14 hours. Upon cooling the mixture was filtered through a “Celite” bed, washed with dichloromethane and the solvent was evaporated in vacuo to obtain crude product.The crude compound was purified by column chromatography (silica, 0-5 % ethyl acetate in ft-hexane) to afford the title compound.1H NMR (DMSO-i) delta ppm 5.14 (s, 2 H), 7.58-7.61 (d, 1 H), 8.01-8.03 (d, 1 H), 8.3 (s, 1 H)

4146-24-1 6-Chloro-2-methylbenzo[d]thiazole 138133, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

4146-24-1, 6-Chloro-2-methylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4146-24-1

General procedure: 2-methylbenzo[d]thiazole (13a, 745mg, 5mmol) was refluxed with selenium dioxide (2775mg, 25mmol) in dioxane for 12h. After completion of the reaction the black solid of Selenium was filtered off on celite and the dioxane was removed under reduced pressure. Water was added to the reaction mixture and the compound was extracted using ethyl acetate. The compound was further purified using column chromatography on silica gel 60-120 mesh to afford the pure solid in moderate yield (52%).

As the paragraph descriping shows that 4146-24-1 is playing an increasingly important role.

Reference：
Article; Shaik, Thokhir B.; Hussaini, S.M. Ali; Nayak, V. Lakshma; Sucharitha, M. Lakshmi; Malik, M. Shaheer; Kamal, Ahmed; Bioorganic and Medicinal Chemistry Letters; vol. 27; 11; (2017); p. 2549 – 2558;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica