Category: 42270-37-1

42270-37-1, 2-(Piperazin-1-yl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,42270-37-1

Hinokitiol (0.29 g, 1.8 mmol), 1-(2-thiazolyl) piperazine (0.30 g, 1.8 mmol) and acetic acid (0.1 mL, 1.8 mmol) were mixed with 10 mL of methanol and then 37% aqueous formalin (0.16 mL, 18 mmol) was added. After stirring at room temperature overnight, 2-hydroxy-4-isopropyl-7-[4-(2-thiazolyl)piperazinomethyl]-2,4,6-cycloheptatrien-1-one (0.3 g, 0.87 mmol, 49%) was obtained by collecting the formed crystals by filtration.

42270-37-1 2-(Piperazin-1-yl)thiazole 911806, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Nippon Kayaku Kabushiki Kaisha; EP1504759; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

42270-37-1, 2-(Piperazin-1-yl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6.11. Preparation of (3′-Chloro-biphenyl-4-yl)-(4-thiazol-2-yl-piperazin-1-yl)-methanone To a solution of 1-(thiazol-2-yl)piperazine (ca. 0.915 mmol, prepared from 150 mg 2-bromothiazole according to the methods described in Astles et al., J. Med. Chem., 39: 1423-1432 (1996)), 3′-chloro-biphenyl-4-carboxylic acid (212.9 mg, 0.915 mmol) in CH2Cl2 (4 ml), was added EDC (209.7 mg, 1.098 mmol) and HOBt (148.2 mg, 1.098 mmol). Aflter being stirred overnight, the mixture was treated with EtOAc (50 ml) and water (15 ml). The organic phase was washed with brine (5 ml), dried (MgSO4), filtered, and concentrated under reduced pressure to furnish the crude product. This material was purified by column chromatography (20% acetone/hexanes) to give the title compound (225 mg, 64% for two steps) as a white solid: 1H NMR (CDCl3, 400 MHz) delta 7.64-7.23 (m, 9 H), 6.65 (t, J=3.6 Hz, 1 H), 4.92 (m, br, 2 H), 3.57 (m, br, 6 H), 3.68 (m, 2 H), 2.14 (m, 2 H), 1.83 (m, 2 H); MS calc’d for C20H19ClN3OS [M+H]+: 384; Found: 384., 42270-37-1

The synthetic route of 42270-37-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Barbosa, Joseph; Dong, Li; Fink, Cynthia Anne; Wang, Jiancheng; Zipp, G. Gregory; US2006/258672; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

42270-37-1, 2-(Piperazin-1-yl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Dissolve ethyl 2-AMINO-5-CHLOROTHIAZOLE-4-CARBOXYLATE (L. OG, 4. 85 mmol) in DMF (6 mL) and heat to 65C. Add dropwise a solution of t-butyl nitrite (0.633 mL) in DMF (10 mL) with stirring. Care: gas evolution. After the addition is complete, stir the reaction mixture for 10 min at 65C and then cool to room temperature. Pour into water and extract the product into diethylether (x2). Combine organic extracts and dry (MGS04) and concentrate to give the titled compound contaminated with trace DMF (590mg). Mass Spectrum (M/E) : 192/194 (M+1)., 42270-37-1

As the paragraph descriping shows that 42270-37-1 is playing an increasingly important role.

Reference：
Patent; ELI LILLY AND COMPANY; WO2005/26177; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

42270-37-1,42270-37-1, 2-(Piperazin-1-yl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[1175] The product from Example 33A (0.2 g, 1.18 mmol), the product from Example 33B (0.25 g, 1.48 mmol) and N,N-diisopropylethylamine (0.41 mL, 2.3 mmol) were combined in toluene (25 mL) and heated at reflux overnight. The reaction was allowed to cool to room temperature, filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (elution with 50% ethyl acetate:hexanes) to provide 0.08 g (22%) of the desired material as a white solid. mp 151-153 C.; 1H NMR (300 MHz, DMSO-d6) delta2.28 (s, 3H), 2.65 (m, 4H), 3.20 (s, 2H), 3.48 (m, 4H), 6.85 (m, 2H), 7.18 (m, 2H), 7.48 (m, 2H), 9.65 (s, 1H); MS (DCI/NH3) m/e 317 (M+H)+; Anal calcd for C16H20N4OS: C, 60.73; H. 6.37; N, 17.71. Found: C, 60.66; H, 6.24; N, 17.35.

As the paragraph descriping shows that 42270-37-1 is playing an increasingly important role.

Reference：
Patent; Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q.; US2003/229094; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42270-37-1,2-(Piperazin-1-yl)thiazole,as a common compound, the synthetic route is as follows.

(2) N-(4-((4-(Thiazol-2-yl)piperazin-1-yl)methyl)phenylmethyl)acetamide Hydrochloride 1/2 Hydrate A solution of N-(4-chloromethylphenylmethyl)acetamide(1.8 g), 1-(thiazol-2-yl)piperazine (1.5 g) and potassium carbonate (1.8 g) in dimethylformamide (20 ml) was stirred at 80 C. for 2.5 hr. The reaction mixture was poured into water (100 ml) and extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give a brown oil. The obtained brown oil was purified by silica gel column chromatography (developing solvent; chloroform_methanol=9:1) to give a pale-brown oil (2.3 g). The obtained pale-brown oil was dissolved in ethanol (200 ml) and 1M hydrogen chloride-ether (7 ml) was added. The solvent was evaporated under reduced pressure. The obtained residue was crystallized from ethyl acetate:ethanol (1:1, 100 ml) and the crystals were recrystallized from ethyl acetate:ethanol:methanol (1:1:1, 100 ml) to give the title compound (1.2 g) as white crystals, m.p.=120-121 C. 1H-NMR(DMSO-d6)delta: 1.89(3H, s), 3.00-3.35(4H, m), 3.50-3.65(2H, m), 3.70-3.80(4H, m), 3.90-4.10(2H, m), 4.28(2H, d, J=5.9 Hz), 4.35(2H, s), 6.99(1H, d, J=4.0 Hz), 7.24(1H, d, J=4.0 Hz), 7.32(1H, d, J=7.9 Hz), 7.61(1H, d, J=7.9 Hz), 8.48(1H, t, J=5.9 Hz), 11.86(1H, brs); IR(KBr): 3311, 2526, 2507, 1641, 1521 cm-1; MS(EI): 330(M+); Elemental analysis: Calculated: C; 54.32, H; 6.44, N; 14.90; Found: C; 54.10, H; 6.31, N; 14.73.

42270-37-1, As the paragraph descriping shows that 42270-37-1 is playing an increasingly important role.

Reference：
Patent; Mitsubishi Pharma Corporation; US6455528; (2002); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42270-37-1,2-(Piperazin-1-yl)thiazole,as a common compound, the synthetic route is as follows.,42270-37-1

6.11. Preparation of f3′-Chloro-biphenyl-4-yl)-f4-thiazol-2-yl-piperazin-l- vl)-methanone; To a solution of l-(thiazol-2-yl)piperazine (ca. 0.915 mmol, prepared from 150 mg 2-bromothiazole according to the methods described in Astles et al., J. Med. Chem., 39: 1423-1432 (1996)), 3′-chloro-biphenyl-4-carboxylic acid (212.9 mg, 0.915 mmol) in CH2Cl2 (4 ml), was added EDC (209.7 mg, 1.098 mmol) and HOBt (148.2 mg, 1.098 mmol). After being stirred overnight, the mixture was treated with EtOAc (50 ml) and water (15 ml). The organic phase was washed with brine (5 ml), dried (MgSO4), filtered, and concentrated under reduced pressure to furnish the crude product. This material was purified by column chromatography (20% acetone/hexanes) to give the title compound (225 mg, 64% for two steps) as a white solid: 1H NMR (CDCl3, 400 MHz) delta 7.64-7.23 (m, 9 H), 6.65 (t, J= 3.6 Hz, 1 H), 4.92 (m, br, 2 H), 3.57 (m, br, 6 H), 3.68 (m, 2 H), 2.14 (m, 2 H), 1.83 (m, 2 H); MS calc’d for C20Hi9ClN3OS [M+H]+: 384; Found: 384.

42270-37-1 2-(Piperazin-1-yl)thiazole 911806, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; LEXICON PHARMACEUTICALS, INC.; WO2008/67121; (2008); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

42270-37-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42270-37-1,2-(Piperazin-1-yl)thiazole,as a common compound, the synthetic route is as follows.

EXAMPLE 50B 1-phenyl-3-[4-(1,3-thiazol-2-yl)piperazin-1-yl]propan-1-one 3-Chloropropiophenone (8 g, 47.44 mmol), the product from Example 50A (8.83 g, 52.18 mmol), and K2CO3 (6.56 g, 47.44 mmol) were combined in DMF and heated at 35 C. for 16 hours. The mixture was allowed to cool to room temperature, diluted with water, and extracted with ethyl acetate. The ethyl acetate extract was dried over anhydrous Na2CO3, filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, 1:1 ethyl acetate:hexanes) to provide the title compound. 1H NMR (300 MHz, CDCl3) delta 2.65 (br.s, 4H), 2.95 (br.s, 2H), 3.22 (br.s. 2H), 3.22 (br.s, 2H), 3.45 (br.s, 4H), 6.45 (d, J=3 Hz, 1H), 7.2 (d, J=3 Hz, 1H), 7.45 (m, 2H), 7.6 (m,1H), 7.9 (m, 2H); MS (DCI/NH3) m/z 302 (M+H)+. Anal. calcd for C16H19N3OS: C, 63.76; H, 6.35; N, 13.94. Found: C, 61.50; H, 6.43; N, 13.21.

42270-37-1 2-(Piperazin-1-yl)thiazole 911806, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Kolasa, Teodzyj; Patel, Meena; Mortell, Kathleen H.; Matulenko, Mark A.; Hakeem, Ahmed A.; Bhatia, Pramila A.; Wang, Xueqing; Daanen, Jerome F.; Latshaw, Steven P.; Stewart, Andrew O.; US2005/176727; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42270-37-1,2-(Piperazin-1-yl)thiazole,as a common compound, the synthetic route is as follows.

The product from Example 33A (0.2 g, 1.18 mmol), the product from Example 33B (0.25 g, 1.48 mmol) and N,N-diisopropylethylamine (0.41 mL, 2.3 mmol) were combined in toluene (25 mL) and heated at reflux overnight. The reaction was allowed to cool to room temperature, filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (elution with 50% ethyl acetate:hexanes) to provide 0.08 g (22%) of the desired material as a white solid. mp 151-153 C.; 1H NMR (300 MHz, DMSO-d6) ? 2.28 (s, 3H), 2.65 (m, 4H), 3.20 (s, 2H), 3.48 (m, 4H), 6.85 (m, 2H), 7.18 (m, 2H), 7.48 (m, 2H), 9.65 (s, 1H); MS (DCI/NH3) m/e 317 (M+H)+; Anal calcd for C16H20N4OS: C, 60.73; H, 6.37; N, 17.71. Found: C, 60.66; H, 6.24; N, 17.35.

42270-37-1, The synthetic route of 42270-37-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Stewart, Andrew O.; Kolasa, Teodozyj; US2003/232836; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica