Category: 425392-45-6

425392-45-6, Ethyl 5-chlorothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,425392-45-6

20 g Ethyl 5-chlorothiazol-4-carboxylate was added to 150 ml ammonia water, and reacted at room temperature with stirring for 5 hr. The resultant reaction mixture was extracted with ethyl acetate, dried over anhydrous sodium sulfate, filtered and concentrated to obtain 9.5 g of a crude product which was recrystallized from ethyl acetate to obtain 5.8 g of a needle crystal (yield 30%) with mp 213-216 C.; 1H NMR (DMSO-d6) 7.69 (1H, s); 7.83 (1H, s); 9.05 (1H, s).

The synthetic route of 425392-45-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Li, Song; Zhao, Guoming; Xia, Guangqiang; Wang, Lili; Zheng, Zhibing; Xie, Yunde; Zhong, Wu; Xiao, Junhai; Li, Xingzhou; Cui, Hao; US2010/87448; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.425392-45-6,Ethyl 5-chlorothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

20 g Ethyl 5-chlorothiazol-4-carboxylate was added to 150 ml ammonia water, and reacted at room temperature with stirring for 5 hr. The resultant reaction mixture was extracted with ethyl acetate, dried over anhydrous sodium sulfate, filtered and concentrated to obtain 9.5 g of a crude product which was recrystallized from ethyl acetate to obtain 5.8 g of a needle crystal (yield 30%) with mp 213-216C; 1H NMR (DMSO-d6) 7.69(1H,s); 7.83 (1H,s); 9.05(1H,s)., 425392-45-6

As the paragraph descriping shows that 425392-45-6 is playing an increasingly important role.

Reference：
Patent; Beijing Molecule Science and Technology Co., Ltd.; EP2039686; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.425392-45-6,Ethyl 5-chlorothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

0.56 g of ethyl mercaptan sodium salt (80%) was added to a mixture of 0.86 g of 5-chlorothiazole-4-carboxylic acid ethyl ester, 3 ml of DMF and 1 ml of THF, under ice cooling, and then the mixture was stirred at room temperature for 1 hour. Water was poured to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.71 g of 5-ethylsulfanylthiazole-4-carboxylic acid ethyl ester., 425392-45-6

425392-45-6 Ethyl 5-chlorothiazole-4-carboxylate 58758599, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Nokura, Yoshihiko; Ito, Mai; Shimizu, Chie; Mizuno, Hajime; US2015/94329; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica