Category: 439134-78-8

In an article, published in an article, once mentioned the application of 439134-78-8, Name is 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole,molecular formula is C12H9BrF3NS, is a conventional compound. this article was the specific content is as follows.Application In Synthesis of 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole

The present invention provides a process for preparing thiazole derivatives of formula (XI), that activate the delta subtype of the human Peroxisome Proliferator Activated Receptor (hPPARdelta), and also provides processes for compounds of formula (VI), (VII), (VIII) and (IX), intermediate compounds for preparation of the above compounds of formula (XI).

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Reference：
Thiazole | C3H5972NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.439134-78-8, Name is 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole, molecular formula is C12H9BrF3NS. In a Patent，once mentioned of 439134-78-8, COA of Formula: C12H9BrF3NS

The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, irritable bowel disorder, inflammation, cataract, cardiovascular diseases, Metabolic X Syndrome, hyper-LDL-cholesterolemia, dyslipidemia (including hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia, and hypo-HDL-cholesterolemia), atherosclerosis, obesity, and other disorders related to lipid metabolism and energy homeostasis complications thereof, using compounds of the invention are also described.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 439134-78-8 is helpful to your research., COA of Formula: C12H9BrF3NS

Reference：
Thiazole | C3H5977NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 439134-78-8. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 439134-78-8, Name is 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole

The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar1, Ar2, L1, L2, n, R1, R4, X and Y are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions

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Reference：
Thiazole | C3H5975NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 439134-78-8, Name is 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole,molecular formula is C12H9BrF3NS, is a conventional compound. this article was the specific content is as follows.Recommanded Product: 439134-78-8

The present invention provides a process for preparing thiazole derivatives of formula (XI), that activate the delta subtype of the human Peroxisome Proliferator Activated Receptor (hPPARdelta), and also provides processes for compounds of formula (VI), (VII), (VIII) and (IX), intermediate compounds for preparation of the above compounds of formula (XI).

Do you like my blog? If you like, you can also browse other articles about this kind. Recommanded Product: 439134-78-8. Thanks for taking the time to read the blog about 439134-78-8

Reference：
Thiazole | C3H5972NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.439134-78-8, Name is 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole, molecular formula is C12H9BrF3NS. In a Patent，once mentioned of 439134-78-8, Recommanded Product: 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole

The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, irritable bowel disorder, inflammation, cataract, cardiovascular diseases, Metabolic X Syndrome, hyper-LDL-cholesterolemia, dyslipidemia (including hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia, and hypo-HDL-cholesterolemia), atherosclerosis, obesity, and other disorders related to lipid metabolism and energy homeostasis complications thereof, using compounds of the invention are also described.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 439134-78-8 is helpful to your research., Recommanded Product: 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole

Reference：
Thiazole | C3H5977NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 439134-78-8, Name is 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole, molecular formula is C12H9BrF3NS. In a Patent，once mentioned of 439134-78-8, name: 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole

The invention discloses a selective PPAR delta agonist GW501516 preparation method, which belongs to the technical field of synthesis of pharmaceutical intermediates. In order to O-methyl phenol as raw materials, and the iodine/potassium bromide through the oxidizing agent to obtain the 4 – iodo/bromo – 2 – methyl phenol, then with the chloro/bromo acetic acid obtained through the reaction of tert-butyl (4 – bromo/iodo – 2 – methyl-phenoxy) – butyl […], followed by Grignard reagent exchange, sequentially with the powder and 5 – (bromomethyl) – 4 – methyl – 2 – [4 – (trifluoromethyl) phenyl] – 1, 3 – thiazole reaction to obtain 2 – [2 – methyl – 4 – – [[ [4 – methyl – 2 – [4 – (trifluoromethyl) phenyl] – 5 – thiazolyl] methyl] thio] phenoxy] acetic acid tert-butyl, finally hydrolyzed to obtain the selective PPAR delta agonist GW501516. The process of the invention the operation is simple, mild condition, raw materials are cheap and easy to obtain, for the synthesizing amplifying of the medicament provides reference. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole. In my other articles, you can also check out more blogs about 439134-78-8

Reference：
Thiazole | C3H5978NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 439134-78-8, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.439134-78-8, Name is 5-(Bromomethyl)-4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole, molecular formula is C12H9BrF3NS. In a patent, introducing its new discovery.

GPR40 (FFA1 and FFAR1) has gained significant interest as a target for the treatment of type 2 diabetes. TAK-875 (1), a GPR40 agonist, lowered hemoglobin A1c (HbA1c) and lowered both postprandial and fasting blood glucose levels in type 2 diabetic patients in phase II clinical trials. We optimized phenylpropanoic acid derivatives as GPR40 agonists and identified AMG 837 (2) as a clinical candidate. Here we report our efforts in searching for structurally distinct back-ups for AMG 837. These efforts led to the identification of more polar GPR40 agonists, such as AM-4668 (10), that have improved potency, excellent pharmacokinetic properties across species, and minimum central nervous system (CNS) penetration.

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Reference£º
Thiazole | C3H5980NS – PubChem,
Thiazole | chemical compound | Britannica