Category: 4464-60-2

Reference of 4464-60-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 4464-60-2, C15H8N2OS2. A document type is Article, introducing its new discovery.

The reaction between bis(2-benzothiazolyl)ketone and vinyl Grignard reagents bearing different substituents on the vinyl moiety gave the product derived from attack on the carbonylic carbon- and/or oxygen-atom. The regioselectivity of the attack depends on the kind of substituents bound to the vinylic carbon atoms and on their relative position. The reaction between vinylmagnesium bromide and 2-methyl-1-propenylmagnesium bromide was carried out under different experimental conditions and in the presence of radical scavengers. The results indicate a plausible mechanistic pathway involving radical intermediates in the case of O-alkylation, but a polar ones in the case of classic C-alkylation. This agrees with our previous reports indicating a key role played by the delocalization ability of the substituents bound to the carbonyl group in driving the regioselectivity of the vinylmagnesium bromide attack towards O-alkylation. Further support of this was obtained by diffractometric analysis of four distinct bis(heteroaryl)ketones.

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Reference：
Thiazole | C3H7658NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 4464-60-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 4464-60-2, C15H8N2OS2. A document type is Article, introducing its new discovery.

The reaction between bis(2-benzothiazolyl)ketone and vinyl Grignard reagents bearing different substituents on the vinyl moiety gave the product derived from attack on the carbonylic carbon- and/or oxygen-atom. The regioselectivity of the attack depends on the kind of substituents bound to the vinylic carbon atoms and on their relative position. The reaction between vinylmagnesium bromide and 2-methyl-1-propenylmagnesium bromide was carried out under different experimental conditions and in the presence of radical scavengers. The results indicate a plausible mechanistic pathway involving radical intermediates in the case of O-alkylation, but a polar ones in the case of classic C-alkylation. This agrees with our previous reports indicating a key role played by the delocalization ability of the substituents bound to the carbonyl group in driving the regioselectivity of the vinylmagnesium bromide attack towards O-alkylation. Further support of this was obtained by diffractometric analysis of four distinct bis(heteroaryl)ketones.

If you are hungry for even more, make sure to check my other article about 4464-60-2. Reference of 4464-60-2

Reference：
Thiazole | C3H7658NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 4464-60-2, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 4464-60-2, Name is Bis(benzo[d]thiazol-2-yl)methanone, molecular formula is C15H8N2OS2. In a Article£¬once mentioned of 4464-60-2

The reaction between bis(2-benzothiazolyl) ketone (1) and a series of ring-substituted phenyl Grignard reagents gives, in considerable amount, the unexpected O-alkylation product derived from the attack of the Grignard reagent to thecarbonyl oxygen atom, thus extending the range of rarely reported cases in which O-alkylation can occur. The expected classic 1,2-addition product and that derived from O-alkylation have been obtained in a relative molar ratio dependent on the substituent on the phenyl ring. Bis(2-benzothiazolyl) aryl carbinols, the classic 1,2-addition products to the carbonyl group of 1, were obtained in high yield through an alternative synthetic route that permitted the limit imposed by O- vs. C-alkylation competition to be overcome. Bis(2-benzothiazolyl) ketone reacts with a series of ring-substituted phenyl Grignard reagents to give in considerable amount the unexpected O-alkylation product derived from attack of the Grignard to the carbonyl oxygen atom. The limit due to O- vs. C-alkylation competition was overcome by an alternative synthetic procedure that gave, in high yields, the classic 1,2-addition products.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 4464-60-2 is helpful to your research., Reference of 4464-60-2

Reference£º
Thiazole | C3H7659NS – PubChem,
Thiazole | chemical compound | Britannica

4464-60-2, An article , which mentions 4464-60-2, molecular formula is C15H8N2OS2. The compound – Bis(benzo[d]thiazol-2-yl)methanone played an important role in people’s production and life.

The reactivity of heteroarylic ketones toward vinylmagnesium bromide (2) and the regiochemistry of the addition were investigated. The reactivity drastically increases when the carbonyl is conjugated with at least one aza group and the regiochemistry of the addition of the vinyl Grignard reagent depends on the carbonyl compound: in the series of di(heteroazolyl) ketones the O-alkylation product was observed as unique with di(1,3-benzothiazol-2-yl) ketone, and in different relative ratios with respect to the classic C-alkylation product with di(1,3-thiazol-2-yl) ketone, (1,3-benzothiazol-2-yl) (1,3-thiazol-2-yl) ketone, and di(1,3-benzoxazol-2-yl) ketone, whereas di(N-methylbenzimidazol-2-yl) ketone gave the exclusive formation of the carbinol. This behavior can be explained by the intervention of the delocalization power of the heterocyclic ring and this was confirmed by the results obtained from the reaction between vinylmagnesium bromide and a series of mixed (1,3-benzothiazol-2-yl) (para-substituted phenyl) ketones, that showed a relative O-/C-alkylation ratio dependent on the nature and on the electronic effect of the substituent on the phenyl ring. The results are in agreement with the existence of intermediate species bearing a negative charge on the benzylic carbonyl carbon atom, and make the O-alkylation reaction between vinyl Grignard reagents and carbonyl compounds no longer a rare case, since it was observed with a number of heterocyclic carbonyl compounds, such as (1,3-benzothiazol-2- yl) aryl ketones and di(heteroaryl) ketones of the pentatomic 1,3-heteroazolic series.

The reactivity of heteroarylic ketones toward vinylmagnesium bromide (2) and the regiochemistry of the addition were investigated. The reactivity drastically increases when the carbonyl is conjugated with at least one aza group and the regiochemistry of the addition of the vinyl Grignard reagent depends on the carbonyl compound: in the series of di(heteroazolyl) ketones the O-alkylation product was observed as unique with di(1,3-benzothiazol-2-yl) ketone, and in different relative ratios with respect to the classic C-alkylation product with di(1,3-thiazol-2-yl) ketone, (1,3-benzothiazol-2-yl) (1,3-thiazol-2-yl) ketone, and di(1,3-benzoxazol-2-yl) ketone, whereas di(N-methylbenzimidazol-2-yl) ketone gave the exclusive formation of the carbinol. This behavior can be explained by the intervention of the delocalization power of the heterocyclic ring and this was confirmed by the results obtained from the reaction between vinylmagnesium bromide and a series of mixed (1,3-benzothiazol-2-yl) (para-substituted phenyl) ketones, that showed a relative O-/C-alkylation ratio dependent on the nature and on the electronic effect of the substituent on the phenyl ring. The results are in agreement with the existence of intermediate species bearing a negative charge on the benzylic carbonyl carbon atom, and make the O-alkylation reaction between vinyl Grignard reagents and carbonyl compounds no longer a rare case, since it was observed with a number of heterocyclic carbonyl compounds, such as (1,3-benzothiazol-2- yl) aryl ketones and di(heteroaryl) ketones of the pentatomic 1,3-heteroazolic series.

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Reference£º
Thiazole | C3H7657NS – PubChem,
Thiazole | chemical compound | Britannica