Category: 494769-34-5

494769-34-5, N-Boc-2-Amino-4-formylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 Synthesis of N-tert-butyl-alpha-[2-N-(1,1-dimethylethoxycarbonyl) aminothiazol-4-yl]nitrone (28) 2.0 g (8.76 mmol) of compound 22, 5.42g (52.57 mmol) of 2-methyl-2-nitropropane (27), and 2.86 g (43.81 mmol) of zinc were placed in a round-bottomed flask along with 95% ethanol (50 mL) and cooled to 0 C. 4.21 g (70.11 mmol) of acetic acid was added slowly with stirring. The solution was allowed to come to room temperature, stirred for 6 hours. CH2Cl2 was added to the reaction mixture and it was filtered through a Celite pad and concentrated under reduced pressure. The residue was purified by short flash column chromatography (silica, Hex_EtOAc=1:1) to give 1.28 g (4.28 mmol) of compound 28 as a yellow solid in 49% yield. 1H NMR (CDCl3): 9.9 (br s, 1H), 8.82 (s, 1H), 7.87 (s, 1H), 1.60 (s, 9H), 1.54 (s, 6H); 13C NMR (CDCl3): 159.54, 152.35, 141.53, 125.78,

494769-34-5, 494769-34-5 N-Boc-2-Amino-4-formylthiazole 23138686, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Ko, Sung-Bo; Oh, Eu-Gene; Kim, Eon-Kyeom; Kim, Won-Yeob; Choi, Dennis W.; Dugan, Laura L.; Koh, Jae-Young; Won, Moo-Ho; Wie, Myung-Bok; US2003/220337; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

494769-34-5, N-Boc-2-Amino-4-formylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,494769-34-5

Example 43; (a) To a solution commercially available 4-iodopyridine (0.82 g, 4.0 mmol) in 10 mL of THF at 0 C was added a 2M solution of EtMgCl in THF (2.0 mL, 4.0 mmol) dropwise. After 1 h, added a solution of 42b (456 mg, 2.0 mmol) in 5 mL of THF. The reaction was allowed to warm to rt and stirred at for 1 hr. The reaction was quenched with water and extracted 2×EtOAC. The EtOAc extracts were dried over MgSO4, concentrated by rotary evaporator, and chromatographed on SiO2 using 50% hexanes in EtOAc then pure EtOAC to give 138 mg (22%) of 43a. MS found: (M+H)+=308.

As the paragraph descriping shows that 494769-34-5 is playing an increasingly important role.

Reference：
Patent; Sheppeck, James; Dhar, T.G. Murali; Doweyko, Lidia; Gilmore, John; Weinstein, David; Xiao, Hai-Yun; Yang, Bingwei V.; Doweyko, Arthur M.; US2006/154973; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

494769-34-5,494769-34-5, N-Boc-2-Amino-4-formylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

nBuLi (575 muL of a 1.6 M solution in hexanes; 0.920 mmol) was added dropwise to a cold (-78 C.) solution of Me(O)P(OEt)2 (134 muL; 0.920 mmol) in THF (0.30 mL). After 20 min a solution of Example 39 Part A compound (100 mg; 0.438 mmol) in THF (0.70 mL) was added dropwise. After 1 h at -78 C, the reaction was quenched by addition of AcOH (63 muL; 1.10 mmol). The reaction was warmed to RT and concentrated using a stream of Ar. The residue was partitioned between EtOAc (5 mL) and brine (4 mL). The organic phase was dried (MgSO4) and concentrated in vacuo. The crude product was chromatographed (SiO2; continuous gradient from 0 to 100% EtOAc in hexanes over 8 min, switch to 4% MeOH in EtOAc and hold for 6 min) to give Part A compound (104 mg; 62%) as a syrup.

The synthetic route of 494769-34-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Bristol-Myers Squibb Company; US2008/9465; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.494769-34-5,N-Boc-2-Amino-4-formylthiazole,as a common compound, the synthetic route is as follows.

TFA (2.0 mL) was added to a 0 C. solution of Part A compound (0.64 g; 2.80 mmol) in DCM (4.0 mL). After 20 h at RT the reaction mixture was concentrated in vacuo. The residue was partitioned between EtOAc (10 mL) and sat. aqueous NaHCO3 (8 mL). The aqueous phase was isolated and extracted with EtOAc (5×8 mL). The combined organic extracts were dried (MgSO4) and concentrated in vacuo to give Part B compound (0.30 g; 83%) as a yellow solid., 494769-34-5

As the paragraph descriping shows that 494769-34-5 is playing an increasingly important role.

Reference：
Patent; Bristol-Myers Squibb Company; US2008/9465; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

494769-34-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.494769-34-5,N-Boc-2-Amino-4-formylthiazole,as a common compound, the synthetic route is as follows.

(c) To a solution commercially available 3-iodopyridine (1.13 g, 5.5 mmol) in 15 mL of THF at 0 C was added a 2M solution of EtMgCl in THF (2.8 mL, 5.6 mmol) dropwise. After 1 h, added a solution of 42b (500 mg, 2.2 mmol) in 5 mL of THF. The reaction was allowed to warm to rt and stirred at for 1 hr. The reaction was quenched with water and extracted 2×EtOAC. The EtOAc extracts were dried over MgSO4, concentrated by rotary evaporator, and chromatographed on SiO2 using 50% hexanes in EtOAc then pure EtOAC to give 336 mg (50%) of 42c. MS found: (M+H)+=308.

494769-34-5 N-Boc-2-Amino-4-formylthiazole 23138686, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Sheppeck, James; Dhar, T.G. Murali; Doweyko, Lidia; Gilmore, John; Weinstein, David; Xiao, Hai-Yun; Yang, Bingwei V.; Doweyko, Arthur M.; US2006/154973; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica