Category: 5053-24-7

Abdelhameed, Ahmed published the artcileSynthesis and antileishmanial evaluation of thiazole orange analogs, Related Products of thiazole, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(1), 126725, database is CAplus and MEDLINE.

A series of 23 analogs of thiazole orange derivatives I [R = H, 5-Me, 8-Ph, etc.; R¹ = Me, Et, n-Pr, Bn; X^– = I, CF₃SO₃], II, III and IV, a com. cyanine dye with antileishmanial activity, were synthesized in an effort to increase the selectivity of such compounds while maintaining efficacy. Cyanines possessing substitutions on the quinolinium ring system displayed potency against Leishmania donovani axenic amastigotes that differed little from the parent compound (IC₅₀ 12-42 nM), while ring disjunction analogs were both less potent and less toxic. Changes in DNA melting temperature were modest when synthetic oligonucleotides were incubated with selected analogs (ΔTm ≤ 5°), with ring disjunction analogs showing the least effected on this parameter. Despite the high antileishmanial potency of the target compounds I, II, III and IV, their toxicity and relatively flat SAR suggested that further information regarding the target(s) of these mols. was needed to aid their development as antileishmanials.

Bioorganic & Medicinal Chemistry Letters published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Related Products of thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Park, Hokoon published the artcileSynthesis and biological activities of C-3 heterocyclyl carbon-substituted new cephalosporins, Name: 2-(Methylthio)thiazole, the publication is Journal of Antibiotics (1994), 47(5), 606-8, database is CAplus and MEDLINE.

Title compounds I [R = (un)substituted 2-thienyl, 5-thiazolyl, 2-pyrrolyl, 2-furyl, 5-isoxazolyl] were prepared via reaction of 3-chloromethyl-7-phenylacetamidocephem with RSnBu₃ and transacylation. Most I were superior to cefixime against gram-pos. organisms, but were inactive against Klebsiella aerogenes, Pseudomonas aeruginosa, and Enterobacter cloacae.

Journal of Antibiotics published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Name: 2-(Methylthio)thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Minster, David K. published the artcileThiazoles from cysteinyl peptides, Application of 2-(Methylthio)thiazole, the publication is Journal of Organic Chemistry (1978), 43(8), 1624-6, database is CAplus.

Glutathione derivative I underwent dehydrative cyclization to thiazoline II which was oxidized by NiO₂ to thiazole III (R = Et, R¹ = Ac) which was hydrolyzed to III (R = R¹ = H), an amino acid derivative from the mushroom Xerocomus subtomentosus. Three thiazoline derivatives were oxidized by NiO₂ to their corresponding thiazoles, whereas 5 other heterocyclic compounds were also dehydrogenated with NiO₂. The thiazoline ring of phleomycin A₂ was oxidized by NiO₂ to the thiazole ring of bleomycin A₂.

Journal of Organic Chemistry published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Application of 2-(Methylthio)thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Miyasaka, Mitsuru published the artcilePalladium-catalyzed direct oxidative alkenylation of azoles, Application of 2-(Methylthio)thiazole, the publication is Journal of Organic Chemistry (2010), 75(15), 5421-5424, database is CAplus and MEDLINE.

The direct heteroaromatic sp² C-H alkenylation of 2-substituted azole compounds with alkenes proceeds in the presence of Pd(OAc)₂ and AgOAc as catalyst and oxidant, resp., to afford the corresponding 5-alkenylated azoles in good yields.

Journal of Organic Chemistry published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Application of 2-(Methylthio)thiazole.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Baell, Jonathan B. published the artcileNew Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays, SDS of cas: 5053-24-7, the publication is Journal of Medicinal Chemistry (2010), 53(7), 2719-2740, database is CAplus and MEDLINE.

This report describes a number of substructural features which can help to identify compounds that appear as frequent hitters (promiscuous compounds) in many biochem. high throughput screens. The compounds identified by such substructural features are not recognized by filters commonly used to identify reactive compounds Even though these substructural features were identified using only one assay detection technol., such compounds have been reported to be active from many different assays. In fact, these compounds are increasingly prevalent in the literature as potential starting points for further exploration, whereas they may not be.

Journal of Medicinal Chemistry published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, SDS of cas: 5053-24-7.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica