Category: 50850-93-6

Related Products of 50850-93-6, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.50850-93-6, Name is Ethyl 2-aminobenzo[d]thiazole-6-carboxylate, molecular formula is C10H10N2O2S. In a patent, introducing its new discovery.

A novel series of 2-amino-6-carboxamidobenzothiazole was discovered to have potent Lck inhibitory properties. A highly efficient chemistry was developed. Also described are the detailed SAR study and the BaF3 cell line profiling for this series.

A novel series of 2-amino-6-carboxamidobenzothiazole was discovered to have potent Lck inhibitory properties. A highly efficient chemistry was developed. Also described are the detailed SAR study and the BaF3 cell line profiling for this series.

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Reference£º
Thiazole | C3H10677NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 50850-93-6, Name is Ethyl 2-aminobenzo[d]thiazole-6-carboxylate,molecular formula is C10H10N2O2S, is a conventional compound. this article was the specific content is as follows.SDS of cas: 50850-93-6

The present invention is directed to substituted benzothiazole and benzoxazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.

The present invention is directed to substituted benzothiazole and benzoxazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.

Do you like my blog? If you like, you can also browse other articles about this kind. SDS of cas: 50850-93-6. Thanks for taking the time to read the blog about 50850-93-6

Reference£º
Thiazole | C3H10643NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50850-93-6, Name is Ethyl 2-aminobenzo[d]thiazole-6-carboxylate, molecular formula is C10H10N2O2S. In a Patent£¬once mentioned of 50850-93-6, Safety of Ethyl 2-aminobenzo[d]thiazole-6-carboxylate

Certain 3,6-disubstituted and 2, 4, 5-trisubstituted pyran derivatives that exhibit potent activity on monoamine transport systems are provided. The 3, 6 and 2, 4, 5 pyrans are useful in probing the effects of their binding to monoamine transporter systems and the corresponding relationships to various afflictions affecting the CNS, or as a treatment for various CNS-related disorders in which the monoamine transport and related systems are implicated.

Certain 3,6-disubstituted and 2, 4, 5-trisubstituted pyran derivatives that exhibit potent activity on monoamine transport systems are provided. The 3, 6 and 2, 4, 5 pyrans are useful in probing the effects of their binding to monoamine transporter systems and the corresponding relationships to various afflictions affecting the CNS, or as a treatment for various CNS-related disorders in which the monoamine transport and related systems are implicated.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Safety of Ethyl 2-aminobenzo[d]thiazole-6-carboxylate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 50850-93-6, in my other articles.

Reference£º
Thiazole | C3H10668NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50850-93-6, Name is Ethyl 2-aminobenzo[d]thiazole-6-carboxylate, molecular formula is C10H10N2O2S. In a Article£¬once mentioned of 50850-93-6, Computed Properties of C10H10N2O2S

There is an urgent need for structurally novel anti-norovirus agents. In this study, we describe the synthesis, anti-norovirus activity, and structure-activity relationship (SAR) of a series of heterocyclic carboxamide derivatives. Heterocyclic carboxamide 1 (50% effective concentration (EC50)=37 muM) was identified by our screening campaign using the cytopathic effect reduction assay. Initial SAR studies suggested the importance of halogen substituents on the heterocyclic scaffold and identified 3,5-di-boromo-thiophene derivative 2j (EC50=24 muM) and 4,6-di-fluoro-benzothiazole derivative 3j (EC50=5.6 muM) as more potent inhibitors than 1. Moreover, their hybrid compound, 3,5-di-bromo-thiophen-4,6-di-fluoro-benzothiazole 4b, showed the most potent anti-norovirus activity with a EC50 value of 0.53 muM (70-fold more potent than 1). Further investigation suggested that 4b might inhibit intracellular viral replication or the late stage of viral infection.

There is an urgent need for structurally novel anti-norovirus agents. In this study, we describe the synthesis, anti-norovirus activity, and structure-activity relationship (SAR) of a series of heterocyclic carboxamide derivatives. Heterocyclic carboxamide 1 (50% effective concentration (EC50)=37 muM) was identified by our screening campaign using the cytopathic effect reduction assay. Initial SAR studies suggested the importance of halogen substituents on the heterocyclic scaffold and identified 3,5-di-boromo-thiophene derivative 2j (EC50=24 muM) and 4,6-di-fluoro-benzothiazole derivative 3j (EC50=5.6 muM) as more potent inhibitors than 1. Moreover, their hybrid compound, 3,5-di-bromo-thiophen-4,6-di-fluoro-benzothiazole 4b, showed the most potent anti-norovirus activity with a EC50 value of 0.53 muM (70-fold more potent than 1). Further investigation suggested that 4b might inhibit intracellular viral replication or the late stage of viral infection.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Computed Properties of C10H10N2O2S. In my other articles, you can also check out more blogs about 50850-93-6

Reference£º
Thiazole | C3H10634NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50850-93-6, Name is Ethyl 2-aminobenzo[d]thiazole-6-carboxylate, molecular formula is C10H10N2O2S. In a Patent£¬once mentioned of 50850-93-6, HPLC of Formula: C10H10N2O2S

Certain 3,6-disubstituted and 2, 4, 5-trisubstituted pyran derivatives that exhibit potent activity on monoamine transport systems are provided. The 3, 6 and 2, 4, 5 pyrans are useful in probing the effects of their binding to monoamine transporter systems and the corresponding relationships to various afflictions affecting the CNS, or as a treatment for various CNS-related disorders in which the monoamine transport and related systems are implicated.

Certain 3,6-disubstituted and 2, 4, 5-trisubstituted pyran derivatives that exhibit potent activity on monoamine transport systems are provided. The 3, 6 and 2, 4, 5 pyrans are useful in probing the effects of their binding to monoamine transporter systems and the corresponding relationships to various afflictions affecting the CNS, or as a treatment for various CNS-related disorders in which the monoamine transport and related systems are implicated.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.HPLC of Formula: C10H10N2O2S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 50850-93-6, in my other articles.

Reference£º
Thiazole | C3H10668NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 50850-93-6, Name is Ethyl 2-aminobenzo[d]thiazole-6-carboxylate,molecular formula is C10H10N2O2S, is a conventional compound. this article was the specific content is as follows.Product Details of 50850-93-6

The present invention is directed to substituted benzothiazole and benzoxazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.

The present invention is directed to substituted benzothiazole and benzoxazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.

Do you like my blog? If you like, you can also browse other articles about this kind. Product Details of 50850-93-6. Thanks for taking the time to read the blog about 50850-93-6

Reference£º
Thiazole | C3H10643NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50850-93-6, Name is Ethyl 2-aminobenzo[d]thiazole-6-carboxylate, molecular formula is C10H10N2O2S. In a Article£¬once mentioned of 50850-93-6, Recommanded Product: 50850-93-6

There is an urgent need for structurally novel anti-norovirus agents. In this study, we describe the synthesis, anti-norovirus activity, and structure-activity relationship (SAR) of a series of heterocyclic carboxamide derivatives. Heterocyclic carboxamide 1 (50% effective concentration (EC50)=37 muM) was identified by our screening campaign using the cytopathic effect reduction assay. Initial SAR studies suggested the importance of halogen substituents on the heterocyclic scaffold and identified 3,5-di-boromo-thiophene derivative 2j (EC50=24 muM) and 4,6-di-fluoro-benzothiazole derivative 3j (EC50=5.6 muM) as more potent inhibitors than 1. Moreover, their hybrid compound, 3,5-di-bromo-thiophen-4,6-di-fluoro-benzothiazole 4b, showed the most potent anti-norovirus activity with a EC50 value of 0.53 muM (70-fold more potent than 1). Further investigation suggested that 4b might inhibit intracellular viral replication or the late stage of viral infection.

There is an urgent need for structurally novel anti-norovirus agents. In this study, we describe the synthesis, anti-norovirus activity, and structure-activity relationship (SAR) of a series of heterocyclic carboxamide derivatives. Heterocyclic carboxamide 1 (50% effective concentration (EC50)=37 muM) was identified by our screening campaign using the cytopathic effect reduction assay. Initial SAR studies suggested the importance of halogen substituents on the heterocyclic scaffold and identified 3,5-di-boromo-thiophene derivative 2j (EC50=24 muM) and 4,6-di-fluoro-benzothiazole derivative 3j (EC50=5.6 muM) as more potent inhibitors than 1. Moreover, their hybrid compound, 3,5-di-bromo-thiophen-4,6-di-fluoro-benzothiazole 4b, showed the most potent anti-norovirus activity with a EC50 value of 0.53 muM (70-fold more potent than 1). Further investigation suggested that 4b might inhibit intracellular viral replication or the late stage of viral infection.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 50850-93-6. In my other articles, you can also check out more blogs about 50850-93-6

Reference£º
Thiazole | C3H10634NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 50850-93-6, Name is Ethyl 2-aminobenzo[d]thiazole-6-carboxylate,molecular formula is C10H10N2O2S, is a conventional compound. this article was the specific content is as follows.category: thiazole

Two regiodivergent approaches to intermolecular cyclization of 2-aminobenzothiazoles with beta-ketoesters and amides have been developed, controlled by the reagents employed. With the Br¡ãnsted base KOt-Bu and CBrCl3 as radical initiator, benzo[d]imidazo[2,1-b]thiazoles are synthesized via attack at the alpha-carbon and keto carbon of the beta-ketoester moiety. In contrast, switching to the Lewis acid catalyst, In(OTf)3, results in the regioselective nucleophilic attack at both carbonyl groups forming benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ones instead.

Two regiodivergent approaches to intermolecular cyclization of 2-aminobenzothiazoles with beta-ketoesters and amides have been developed, controlled by the reagents employed. With the Br¡ãnsted base KOt-Bu and CBrCl3 as radical initiator, benzo[d]imidazo[2,1-b]thiazoles are synthesized via attack at the alpha-carbon and keto carbon of the beta-ketoester moiety. In contrast, switching to the Lewis acid catalyst, In(OTf)3, results in the regioselective nucleophilic attack at both carbonyl groups forming benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ones instead.

Do you like my blog? If you like, you can also browse other articles about this kind. category: thiazole. Thanks for taking the time to read the blog about 50850-93-6

Reference£º
Thiazole | C3H10629NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.50850-93-6, Name is Ethyl 2-aminobenzo[d]thiazole-6-carboxylate, molecular formula is C10H10N2O2S. In a Article£¬once mentioned of 50850-93-6, Formula: C10H10N2O2S

Treatment of AML patients with small molecule inhibitors of FLT3 kinase has been explored as a viable therapy. However, these agents are found to be less than optimal for the treatment of AML because of lack of sufficient potency or suboptimal oral pharmacokinetics (PK) or lack of adequate tolerability at efficacious doses. We have developed a series of extremely potent and highly selective FLT3 inhibitors with good oral PK properties. The first series of compounds represented by 1 (AB530) was found to be a potent and selective FLT3 kinase inhibitor with good PKproperties. The aqueous solubility and oralPK properties at higher doses in rodents were found to be less than optimal for clinical development.Anovel series of compounds were designed lacking the carboxamide group of 1 with an added water solubilizing group. Compound 7 (AC220) was identified from this series to be the most potent and selective FLT3 inhibitor with good pharmaceutical properties, excellent PK profile, and superior efficacy and tolerability in tumor xenograft models. Compound 7 has demonstrated a desirable safety and PK profile in humans and is currently in phase II clinical trials.

Treatment of AML patients with small molecule inhibitors of FLT3 kinase has been explored as a viable therapy. However, these agents are found to be less than optimal for the treatment of AML because of lack of sufficient potency or suboptimal oral pharmacokinetics (PK) or lack of adequate tolerability at efficacious doses. We have developed a series of extremely potent and highly selective FLT3 inhibitors with good oral PK properties. The first series of compounds represented by 1 (AB530) was found to be a potent and selective FLT3 kinase inhibitor with good PKproperties. The aqueous solubility and oralPK properties at higher doses in rodents were found to be less than optimal for clinical development.Anovel series of compounds were designed lacking the carboxamide group of 1 with an added water solubilizing group. Compound 7 (AC220) was identified from this series to be the most potent and selective FLT3 inhibitor with good pharmaceutical properties, excellent PK profile, and superior efficacy and tolerability in tumor xenograft models. Compound 7 has demonstrated a desirable safety and PK profile in humans and is currently in phase II clinical trials.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C10H10N2O2S, you can also check out more blogs about50850-93-6

Reference£º
Thiazole | C3H10631NS – PubChem,
Thiazole | chemical compound | Britannica

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 50850-93-6, C10H10N2O2S. A document type is Patent, introducing its new discovery., Recommanded Product: 50850-93-6

The present invention relates to compounds having a structure of general formula (I), processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in humans and warm-blooded animals.

The present invention relates to compounds having a structure of general formula (I), processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in humans and warm-blooded animals.

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Reference£º
Thiazole | C3H10639NS – PubChem,
Thiazole | chemical compound | Britannica