Category: 5198-86-7

5198-86-7, Name is (2-Bromothiazol-4-yl)methanol, molecular formula is C4H4BrNOS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 5198-86-7, Product Details of 5198-86-7

The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Product Details of 5198-86-7. In my other articles, you can also check out more blogs about 5198-86-7

Reference£º
Thiazole | C3H37NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 5198-86-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 5198-86-7, C4H4BrNOS. A document type is Patent, introducing its new discovery.

The present invention relates to substituted alkyl carboxylic acid derivatives (the compounds of Formula (I)), processes for their preparation, pharmaceutical compositions containing said compounds, their use as GPR (G-protein coupled receptor) agonists, particularly as GPR40 agonists and methods of using these compounds in the treatment of GPR40 mediated diseases or conditions.

The present invention relates to substituted alkyl carboxylic acid derivatives (the compounds of Formula (I)), processes for their preparation, pharmaceutical compositions containing said compounds, their use as GPR (G-protein coupled receptor) agonists, particularly as GPR40 agonists and methods of using these compounds in the treatment of GPR40 mediated diseases or conditions.

If you are hungry for even more, make sure to check my other article about 5198-86-7. Electric Literature of 5198-86-7

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Thiazole | C3H34NS – PubChem,
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5198-86-7,(2-Bromothiazol-4-yl)methanol,as a common compound, the synthetic route is as follows.

5198-86-7, Step 4 : 2-bromo-4-(iodomethyl)thiazoleA cooled solution of 2-bromothiazol-4-yl)methanol (1.488 g, 7.668 mmol) , triphenylphosphine(3.016 g, 2.664 mL, 11.50 mmol) and 4H-imidazole (1.044 g, 15.34 mmol) in THF (20 mL) under nitrogen was treated with molecular iodine (2.919 g, 592.1 muL, 11.50 mmol) in one portion and the reaction maintained at this temperature. After 1 hour the reaction mixture was diluted with water and extracted with EtOAc. The organic layer was washed with 1percent sodium metabisulfite solution followed by brine and dried over MgSO4 The mixture was concentrated in vacuo and purified using column chromatography (3: 1 Petroleum ether/EtOAc) to give the pure product as a white solid (2.12g, 91percent Yield). 1H NMR (CDCl3, 400 MHz) delta 4.49 (2H, s), 7.22 (IH, s); MS (ES+)

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Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; JIMENEZ, Juan-Miguel; COLLIER, Philip, N.; WO2010/129668; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica