Category: 53572-98-8

Downstream synthetic route of 53572-98-8

The synthetic route of 53572-98-8 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53572-98-8,Imidazo[2,1-b]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of the respective carboxylic acid (0.030 mmol, 1.8 eq) in DMF (0.25 mL) is added successively a solution of DIPEA (0.075 mmol, 4.4 eq) in DMF (0.15 mL) and a solution of TBTU (0.030 mmol, 1.8 eq) in DMF (0.15 mL). The obtained mixture is treated with a solution of the respective 3-aza-bicyclo[3.1.0]hexane derivative (0.017 mmol, 1.0 eq, free base) in DMF (0.15 mL). The mixture is shaken over night and purified by prep. HPLC to give the respective amide derivatives. prepared by reaction of [(1R*,2S*,5S*)-2-aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl]-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with imidazo[2,1-b]thiazole-6-carboxylic acid. LC-MS: tR=0.84 min; [M+H]+=478.1., 53572-98-8

The synthetic route of 53572-98-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Actelion Phamaceuticals Ltd.; US2010/16401; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

Some tips on 53572-98-8

As the paragraph descriping shows that 53572-98-8 is playing an increasingly important role.

53572-98-8, Imidazo[2,1-b]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

53572-98-8, B.3 Synthesis of carboxylic amide derivatives (general procedure II); To a solution of the respective carboxylic acid (0.030 mmol, 1.8eq) in DMF (0.25 mL) is added successively a solution of DIPEA (0.075 mmol, 4.4eq) in DMF (0.15 mL) and a solution of TBTU (0.030 mmol, 1.8eq) in DMF (0.15 mL). The obtained mixture is treated with a solution of the respective 3-aza-bicyclo[3.1.0]hexane derivative (0.017 mmol, l.Oeq, free base) in DMF (0.15 mL). The mixture is shaken over night and purified by prep. HPLC to give the respective amide derivatives.Example 65: imidazo[2,l-b]thiazole-6-carboxylic acid [(lR*,2S*,5S*)-3-(2-methyl-5-m-tolyl- thiazole-4-carbonyl)-3-aza-bicyclo[3.1.0]hex-2-ylmethyl]-amide prepared by reaction of [(1R ,2S ,5S )-2-aminomethyl-3-aza-bicyclo[3.1.0]hex-3-yl]- (2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with imidazo[2, 1 -b]thiazole-6- carboxylic acid. LC-MS: tR = 0.84 min; [M+H]+ = 478.1.

As the paragraph descriping shows that 53572-98-8 is playing an increasingly important role.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2008/38251; (2008); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica