Category: 556-90-1

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of cyclohexyl-2-(phenylimino)-4-thiazolidineione,3-methyl-2-(phenylimino) thiazolidine-4-one, thiazolidine-2,4-dione, 3-methyl thiazolidine-2,4-dione or imidazolidine-2,4-dione (1.0 equiv) in absolute ethanol (15 mL) was added theappropriate 2,5-dimethyl-1-aryl -3-formylpyrrole (1.1 equiv),piperidine (1.2 equiv) and 3 molecular sieves. The mixture washeated to reflux at 90 C for 8e10 h, cooled, filtered and concentratedin vacuo. The residue was purified by column chromatographyon a silica gel column (ethylacetate/hexane ordichloromethane/hexane) and in some cases recrystallized frommethanol to give 20e54 as generally yellowish solids.

556-90-1, 556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Mital, Alka; Murugesan, Dinakaran; Kaiser, Marcel; Yeates, Clive; Gilbert, Ian H.; European Journal of Medicinal Chemistry; vol. 103; (2015); p. 530 – 538;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.

General procedure: To a solution of the pseudothiohydantoin 6a (139 mg, 1.2 mmol), and sodium acetate (328 mg, 4.0 mmol) in acetic acid (5 ml) was added 5-phenyl-2-furaldehyde 5a (172 mg,1.0 mmol) at 25C. The solution was refluxed at 135C for 12 h. The precipitate was filtered and washed with water and diethyl ether. The filter cake was dried under high vacuum to afford 230 mg (85%) of compound 7a as an orange solid.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Jung, Michael E.; Ku, Jin-Mo; Du, Liutao; Hu, Hailiang; Gatti, Richard A.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 19; (2011); p. 5842 – 5848;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,556-90-1

General procedure: To the magnetically stirred solution of 17 (232 mg, 2 mmol) in HOAc (7 mL), was added NaOAc (500 mg, 6 mmol). After 15 min 3,4-dimethoxybenzaldhyde (16a, 400 mg, 2.4 mmol) was added and the reaction mixture was heated under reflux for 72 h. The HOAc was removed under reduced pressure and the resultant solid was washed successively with water, methanol and EtOAc to obtain the desired products as solid. 10.2.1.4 5-(4-Hydroxy-3-nitrobenzylidene)-2-iminothiazolidin-4-one (14d) Orange solid; mp > 200 C; 330 mg, 61% yield; IR (neat) numax = 3164, 2772, 1679, 1604 cm-1; 1H NMR (400 MHz, CD3SOCD3) delta 9.46 (br s, 1H), 9.18 (s, 1H), 8.05 (s, 1H), 7.75 (d, J = 8.74, 1H), 7.55 (s, 1H), 7.24 (d, J = 8.72, 1H); 13C NMR (100 MHz, CD3SOCD3): delta 180.71, 175.57, 153.52, 137.52, 136.46, 129.04, 127.52, 126.27, 125.66, 120.53 HRMS (ESI-TOF): m/z calculated for C10H7N3O4S [M+Na]+, 288.0055; found 288.0046.

As the paragraph descriping shows that 556-90-1 is playing an increasingly important role.

Reference£º
Article; Arfeen, Minhajul; Bhagat, Shweta; Patel, Rahul; Prasad, Shivcharan; Roy, Ipsita; Chakraborti, Asit K.; Bharatam, Prasad V.; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 727 – 736;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

556-90-1, General procedure: To the magnetically stirred solution of 17 (232 mg, 2 mmol) in HOAc (7 mL), was added NaOAc (500 mg, 6 mmol). After 15 min 3,4-dimethoxybenzaldhyde (16a, 400 mg, 2.4 mmol) was added and the reaction mixture was heated under reflux for 72 h. The HOAc was removed under reduced pressure and the resultant solid was washed successively with water, methanol and EtOAc to obtain the desired products as solid. 10.2.1.3 5-(4-Hydroxy-3-methoxybenzylidene)-2-iminothiazolidin-4-one (14c) Yellow solid; mp > 200 C; 215 mg, 43% yield; IR (neat) numax = 3364, 2955, 1735, 1680, 1584 cm-1; 1H NMR (400 MHz, CD3SOCD3) delta 9.76 (s, 1H), 9.29 (br s, 1H), 9.05 (s, 1H), 7.50 (s, 1H), 7.13 (s, 1H), 7.06 (d, J = 8.28, 1H), 6.9 (d, J = 7.92, 1H); 13C NMR (100 MHz, CD3SOCD3): delta 175.91, 148.92, 148.35, 130.35, 125.94, 125.81, 123.69, 116.49, 113.88, 56.00; HRMS (ESI-TOF): m/z calculated for C11H10N2O3S [M+H]+, 251.0490; found 251.0491.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Arfeen, Minhajul; Bhagat, Shweta; Patel, Rahul; Prasad, Shivcharan; Roy, Ipsita; Chakraborti, Asit K.; Bharatam, Prasad V.; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 727 – 736;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1,556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To the magnetically stirred solution of 17 (232 mg, 2 mmol) in HOAc (7 mL), was added NaOAc (500 mg, 6 mmol). After 15 min 3,4-dimethoxybenzaldhyde (16a, 400 mg, 2.4 mmol) was added and the reaction mixture was heated under reflux for 72 h. The HOAc was removed under reduced pressure and the resultant solid was washed successively with water, methanol and EtOAc to obtain the desired products as solid. 10.2.1.8 5-(4-Chloro-3-nitrobenzylidene)-2-iminothiazolidin-4-one (14h) Orange solid; mp > 200 C; 338 mg, 60% yield; IR (neat) numax = 3214, 3009, 1965, 1693, 1667 cm-1; 1H NMR (400 MHz, CD3SOCD3) delta 9.58 (s, 1H), 9.33 (s, 1H) 8.20 (s, 1H), 7.82-7.89 (m, 2H), 7.62 (s, 1H); 13C NMR (100 MHz, CD3SOCD3): delta 180.28, 175.47, 148.21, 135.23, 134.26, 133.46 132.95, 126.39, 125.98, 125.79; HRMS (ESI-TOF): m/z calculated for C10H6ClN3O3S [M+Na]+, 305.9716; found 305.9712.

The synthetic route of 556-90-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Arfeen, Minhajul; Bhagat, Shweta; Patel, Rahul; Prasad, Shivcharan; Roy, Ipsita; Chakraborti, Asit K.; Bharatam, Prasad V.; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 727 – 736;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.

556-90-1, General procedure: To a solution of the pseudothiohydantoin 6a (139 mg, 1.2 mmol), and sodium acetate (328 mg, 4.0 mmol) in acetic acid (5 ml) was added 5-phenyl-2-furaldehyde 5a (172 mg,1.0 mmol) at 25C. The solution was refluxed at 135C for 12 h. The precipitate was filtered and washed with water and diethyl ether. The filter cake was dried under high vacuum to afford 230 mg (85%) of compound 7a as an orange solid.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Jung, Michael E.; Ku, Jin-Mo; Du, Liutao; Hu, Hailiang; Gatti, Richard A.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 19; (2011); p. 5842 – 5848;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,556-90-1

A solution of N-(4-ethoxy-6-fromyl-quinolin-2-yl)-acetamide (example 2e, 50 mg, 0.19 mmol) in acetic acid (1.5 ml) was treated with pseudothiohydantoin (34 mg, 0.29 mmol) and sodium acetate (63 mg, 0.77 mmol) in a microwave synthesizer at 180 C. for 45 min. The mixture was partitioned between 1N NaOH and dichloromethane. The aqueous layer, which contained the desired product, was concentrated to dryness and the crude residue was purified by RP HPLC to afford the product as the TFA salt (5 mg, 8%). LC-MS m/e 315 (MH+).

As the paragraph descriping shows that 556-90-1 is playing an increasingly important role.

Reference£º
Patent; Chen, Li; Chen, Shaoqing; Michoud, Christophe; US2006/63804; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,556-90-1

2a (1 g, 8.62 mmol) was added to 15 mL of 20% dilute hydrochloric acid and refluxed for 10h. It was concentrated and cooled giving a white solid precipitate. It was filtered, washed, and recystallized with 70% ethanol. Dried to obtain 0.78 g of white needle-like crystals, yield 77.2%.

The synthetic route of 556-90-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; China Pharmaceutical University; Lai, Yisheng; Wang, Hui; Sun, Qirui; Zhang, Yingyi; Li, Yuezhen; Zhang, Yihua; (22 pag.)CN105884712; (2016); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica