Category: 56354-98-4

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.56354-98-4, Name is 6-Aminobenzo[d]thiazol-2(3H)-one, molecular formula is C7H6N2OS. In a Article，once mentioned of 56354-98-4, Formula: C7H6N2OS

A novel series of Schiff bases derivatives containing the benzothiazolone moiety have been synthesized in a simple and efficient method, by condensation of 6-amino-2(3H)-benzothiazolone substrates with different aromatic aldehydes, in refluxing ethanol and in the presence of acetic acid as catalyst. The structure of synthesized compounds was elucidated and has been proven using spectral methods such as 1H NMR, 13C NMR and elemental analysis. All the newly synthesized compounds were in good agreement with the proposed structures.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C7H6N2OS, you can also check out more blogs about56354-98-4

Reference：
Thiazole | C3H6769NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 56354-98-4, Name is 6-Aminobenzo[d]thiazol-2(3H)-one, COA of Formula: C7H6N2OS.

Chemical probes of epigenetic ?readers? of histone post-translational modifications (PTMs) have become powerful tools for mechanistic and functional studies of their target proteins in physiology and pathology. However, only limited ?reader? probes have been developed, which restricted our understanding towards these macromolecules and their roles in cells or animals. Here, we reported a structure-guided approach to develop and characterize benzo [d]oxazol-2(3H)-one analogs as the first potent and selective small-molecule inhibitors of chromodomain Y-like (CDYL), a histone methyllysine reader protein. The binding conformation between the chromodomain of CDYL and the modified peptidomimetics was studied via molecular docking and dynamic simulations, facilitating subsequent virtual screening of tens of hits from Specs chemical library validated by SPR technique (KD values: from 271.1 muM to 5.4 muM). Further design and synthesis of 43 compounds helped to interpret the structure-activity relationship (SAR) that lead to the discovery of novel small-molecule inhibitors of CDYL. Compound D03 (KD: 0.5 muM) was discovered and showed excellent selectivity among other chromodomain proteins, including CDYL2 (>140 folds), CDY1 (no observed binding) and CBX7 (>32 folds). Moreover, we demonstrated that D03 engaged with endogenous CDYL in a dose-dependent manner, and perturbed the recruitment of CDYL onto chromatin, resulting in transcriptional derepression of its target genes. Finally, the results showed that D03 promoted the development and branching of neurodendrites by inhibiting CDYL in hippocampal and cortical cultured neurons. This study not only discovers the first selective small-molecule inhibitors of CDYL, but provids a new chemical tool to intervene the dynamic nature of bio-macromolecules involved in epigenetic mechanism.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.COA of Formula: C7H6N2OS. In my other articles, you can also check out more blogs about 56354-98-4

Reference：
Thiazole | C3H6766NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 56354-98-4, Name is 6-Aminobenzo[d]thiazol-2(3H)-one, HPLC of Formula: C7H6N2OS.

Microwave-assisted synthesis of new imide-and formamide-derivatives of 2(3H)-benzoxazolinones and 2(3H)-benzothiazolinones

With the aim to obtain 2(3H)-benzoxazolinones and 2(3H)-benzothiazolinone derivatives, we synthesized new imide compounds 5a-c, 6c-d and 7a-d by treating their 6-amino precursors with succinic, maleic or phthalic anhydride. The microwave (MW)-assisted reaction provided them more efficiently than through the corresponding isolated amic acids. The same nucleophile reagents were used in a MW-assisted formylation to obtain new formamide products 8-11, that were detected as cis/trans forms by NMR analysis. The ratio was in favor of the cis isomer and affected by the solvent, as also supported by DFT calculations.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.HPLC of Formula: C7H6N2OS. In my other articles, you can also check out more blogs about 56354-98-4

Reference：
Thiazole | C3H6755NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.56354-98-4, Name is 6-Aminobenzo[d]thiazol-2(3H)-one, molecular formula is C7H6N2OS. In a Patent£¬once mentioned of 56354-98-4, Formula: C7H6N2OS

Compounds of the formula STR1 where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R2 is hydrogen, alkyl or alkanoyl and X is C=O, CH2, NH, O or S as antiallergy and antiinflammatory agents.

Compounds of the formula STR1 where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R2 is hydrogen, alkyl or alkanoyl and X is C=O, CH2, NH, O or S as antiallergy and antiinflammatory agents.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 56354-98-4 is helpful to your research., Formula: C7H6N2OS

Reference£º
Thiazole | C3H6764NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 56354-98-4, Name is 6-Aminobenzo[d]thiazol-2(3H)-one,molecular formula is C7H6N2OS, is a conventional compound. this article was the specific content is as follows.Safety of 6-Aminobenzo[d]thiazol-2(3H)-one

Compounds of formula (I): 1wherein: X represents an oxygen atom or a sulphur atom or a group CH2 or 2R1 and R2 represent a hydrogen atom, or a group as defined in the description, A represents an alkylene chain as described in the description, B is as defined in the description, R3 and R4 represent a hydrogen atom or a group as defined in the description, D represents an optionally substituted benzene, optionally substituted pyrazine, optionally substituted pyrimidine or optionally substituted pyridazine nucleus.

Compounds of formula (I): 1wherein: X represents an oxygen atom or a sulphur atom or a group CH2 or 2R1 and R2 represent a hydrogen atom, or a group as defined in the description, A represents an alkylene chain as described in the description, B is as defined in the description, R3 and R4 represent a hydrogen atom or a group as defined in the description, D represents an optionally substituted benzene, optionally substituted pyrazine, optionally substituted pyrimidine or optionally substituted pyridazine nucleus.

Do you like my blog? If you like, you can also browse other articles about this kind. Safety of 6-Aminobenzo[d]thiazol-2(3H)-one. Thanks for taking the time to read the blog about 56354-98-4

Reference£º
Thiazole | C3H6765NS – PubChem,
Thiazole | chemical compound | Britannica

56354-98-4, Name is 6-Aminobenzo[d]thiazol-2(3H)-one, molecular formula is C7H6N2OS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 56354-98-4, Quality Control of: 6-Aminobenzo[d]thiazol-2(3H)-one

Compounds of the formula STR1 where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R2 is hydrogen, alkyl or alkanoyl and X is C=O, CH2, NH, O or S as antiallergy and antiinflammatory agents.

Compounds of the formula STR1 where Y is alkyl, aryl or heterocyclic, n is 1-7, R is hydrogen, alkyl, aralkyl or carboxymethyl, R1 is acetoxy, thiophenoxy, hydrogen, halo, alkyl, alkoxy or trifluoromethyl, R2 is hydrogen, alkyl or alkanoyl and X is C=O, CH2, NH, O or S as antiallergy and antiinflammatory agents.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: 6-Aminobenzo[d]thiazol-2(3H)-one. In my other articles, you can also check out more blogs about 56354-98-4

Reference£º
Thiazole | C3H6763NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 56354-98-4. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 56354-98-4, Name is 6-Aminobenzo[d]thiazol-2(3H)-one. In a document type is Article, introducing its new discovery.

A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.

A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.

If you are interested in 56354-98-4, you can contact me at any time and look forward to more communication.Application of 56354-98-4

Reference£º
Thiazole | C3H6770NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.56354-98-4, Name is 6-Aminobenzo[d]thiazol-2(3H)-one, molecular formula is C7H6N2OS. In a Patent£¬once mentioned of 56354-98-4, SDS of cas: 56354-98-4

The present invention relates to substituted pyrrolopyrimidinylamino-benzothiazolone compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

The present invention relates to substituted pyrrolopyrimidinylamino-benzothiazolone compounds of general formula I as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 56354-98-4 is helpful to your research., SDS of cas: 56354-98-4

Reference£º
Thiazole | C3H6758NS – PubChem,
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56354-98-4,6-Aminobenzo[d]thiazol-2(3H)-one,as a common compound, the synthetic route is as follows.,56354-98-4

General procedure: To a stirred suspension of benzo [d]oxazol-2(3H)-one derivative,or benzimidazole, or 2H-benzo [b] [1,4]oxazin-3(4H)-one(1.0 mmol), anhydrous K2CO3 (1.2 mmol) was added in the DMFsolvent for 20 min at 70 C. Then bromoacetylated 1a-1f or 2a-2c(1.3 mmol) and TBAI (0.1 mmol) were added simultaneously. Thereaction was stirred and heated for 4 h. After completion, themixture was extracted with EtOAc/H2O three times. The combinedorganic layers were washed with brine, dried over anhydrousNa2SO4, filtered and concentrated under reduced pressure. Thecrude product was purified by silica gel column chromatographyeluting with EtOAc/PE (3:1e8:1) to afford compounds B01-B29,C01-C03.

As the paragraph descriping shows that 56354-98-4 is playing an increasingly important role.

Reference£º
Article; Yang, Lixin; Liu, Yongqing; Fan, Minghua; Zhu, Guiwang; Jin, Hongwei; Liang, Jing; Liu, Zhenming; Huang, Zhuo; Zhang, Liangren; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica