Category: 564443-27-2

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 564443-27-2, C7H3F3N2OS. A document type is Patent, introducing its new discovery., Safety of 6-(Trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde

The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

Interested yet? Keep reading other articles of 564443-27-2!, Safety of 6-(Trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde

Reference：
Thiazole | C3H6751NS – PubChem,
Thiazole | chemical compound | Britannica

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 564443-27-2, C7H3F3N2OS. A document type is Patent, introducing its new discovery., Computed Properties of C7H3F3N2OS

The invention relates to novel 2-aza-bicyclo[3.1.0]hexane derivatives of Formula (I) wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

Interested yet? Keep reading other articles of 564443-27-2!, Computed Properties of C7H3F3N2OS

Reference：
Thiazole | C3H6753NS – PubChem,
Thiazole | chemical compound | Britannica

564443-27-2, Name is 6-(Trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde, molecular formula is C7H3F3N2OS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 564443-27-2, Quality Control of: 6-(Trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde

A new class of imidazo[2,1-b]thiazole chalcone derivatives were synthesized and evaluated for their anticancer activity. These chalcone derivatives show promising activity, with logGI50 values ranging from -7.51 to -4.00. The detailed biological aspects of these derivatives toward the MCF-7 cell line were studied. Interestingly, these chalcone derivatives induced G 0/G1-phase cell-cycle arrest, down-regulation of G 1-phase cell-cycle regulatory proteins such as cyclin D1 and cyclin E1, and up-regulation of CDK4. Moreover, these compounds elicit the characteristic features of apoptosis such as enhancement in the levels of p53, p21, and p27, suppression of NF-kappaB, and up-regulation of caspase-9. One of these chalcone derivatives, 3d, is potentially well suited for detailed biological studies, either alone or in combination with existing therapies. Breaking the cycle: We undertook an extensive examination of the ability of a series of new chalcone derivatives to regulate the cell cycle and to induce apoptosis in various cancer cell lines. Compound 3d is a particularly suitable candidate for further detailed biological investigations, especially in the treatment of breast cancer.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: 6-(Trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde. In my other articles, you can also check out more blogs about 564443-27-2

Reference：
Thiazole | C3H6754NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 564443-27-2, Name is 6-(Trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde, molecular formula is C7H3F3N2OS. In a Patent，once mentioned of 564443-27-2, Product Details of 564443-27-2

The present invention provides a compounds 7a-f to 18a-f and 19a-f to 30a-f of general formula (A), useful as potential anticancer agents against human cancer cell lines. The present invention further provides a process for the preparation of imidazothiazole-chalcone hybrids 7a-f to 18a-f and 19a-f to 30a-f of general formula A. wherein R = H for 7a-f to18a-f R = CH3 for 19a-f to 30a-f

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Product Details of 564443-27-2. In my other articles, you can also check out more blogs about 564443-27-2

Reference：
Thiazole | C3H6749NS – PubChem,
Thiazole | chemical compound | Britannica

564443-27-2, Name is 6-(Trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde, molecular formula is C7H3F3N2OS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 564443-27-2, Computed Properties of C7H3F3N2OS

The invention relates to novel azetidine compounds of formula (I), wherein R1, R2, and X are as described in the description and their use as orexin receptor antagonists.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Computed Properties of C7H3F3N2OS. In my other articles, you can also check out more blogs about 564443-27-2

Reference：
Thiazole | C3H6752NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 564443-27-2. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 564443-27-2, Name is 6-(Trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde

The pharmacology of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel has attracted significant interest in recent years with the aim to search for rational new therapies for diseases caused by CFTR malfunction. Mutations that abolish the function of CFTR cause the life-threatening genetic disease cystic fibrosis (CF). The most common cause of CF is the deletion of phenylalanine 508 (DeltaF508) in the CFTR chloride channel. Felodipine, nifedipine, and other antihypertensive 1,4-dihydropyridines (1,4-DHPs) that block L-type Ca2+ channels are also effective potentiators of CFTR gating, able to correct the defective activity of DeltaF508 and other CFTR mutants (Mol. Pharmacol. 2005, 68, 1736). For this purpose, we evaluated the ability of the previously and newly synthesized 4-imidazo[2,1-b]thiazoles-1,4-dihydropyridines without vascular activity and inotropic and/or chronotropic cardiac effects (J. Med. Chem. 2008, 51, 1592) to enhance the activity of DeltaF508-CFTR. Our studies indicate compounds 17, 18, 20, 21, 38, and 39 as 1,4-DHPs with an interesting profile of activity.

If you are hungry for even more, make sure to check my other article about 564443-27-2. Synthetic Route of 564443-27-2

Reference£º
Thiazole | C3H6750NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 564443-27-2. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 564443-27-2, Name is 6-(Trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde. In a document type is Article, introducing its new discovery.

The synthesis, characterization, and functional in vitro assay in cardiac and smooth muscle (vascular and nonvascular) of a series of 4-imidazo[2,1-b] thiazole-1,4-dihydropyridines are reported. To define the calcium blocker nature of the imidazo[2,1-b]thiazole-1,4-DHPs and their selectivity on Ca v1.2 and Cav1.3 isoforms, we performed binding studies on guinea pig atrial and ventricular membranes on intact cells expressing the cloned Cav1.2a subunit and on rat brain cortex. To get major insights into the reasons for the affinity for Cav1.2 and/or Ca v1.3, molecular modeling studies were also undertaken. Some physicochemical and pharmacokinetic properties of selected compounds were calculated and compared. All the biological data collected and reported herein allowed us to rationalize the structure-activity relationship of the 4-imidazo[2,1-b]thiazole-1,4-DHPs and to identify which of these enhanced the activity at the central level.

If you are interested in 564443-27-2, you can contact me at any time and look forward to more communication.Application of 564443-27-2

Reference£º
Thiazole | C3H6748NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 564443-27-2, An article , which mentions 564443-27-2, molecular formula is C7H3F3N2OS. The compound – 6-(Trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde played an important role in people’s production and life.

The synthesis, characterization, and functional in vitro assays in cardiac tissues and smooth muscle (vascular and nonvascular) of a number of 4-imidazo[2,1-b]thiazole-1,4-dihydropyridines are reported. The binding properties for the novel compounds have been investigated and the interaction with the binding site common to other aryl-dihydropyridines has been demonstrated. Interestingly, the novel 4-aryl-dihydropyridines are L-type calcium channel blockers with a peculiar pharmacological behavior. Indeed, the imidazo[2,1-b]thiazole system is found to confer to the dihydropyridine scaffold an inotropic and/or chronotropic cardiovascular activity with a high selectivity toward the nonvascular tissue. Finally, molecular modeling studies were undertaken for the most representative compounds with the aim of describing the binding properties of the new ligands at molecular level and to rationalize the found structure-activity relationship data. Due to the observed pharmacological behavior of our compounds, they might be promising agents for the treatment of specific cardiovascular pathologies such as cardiac hypertrophy and ischemia.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 564443-27-2, help many people in the next few years., Related Products of 564443-27-2

Reference£º
Thiazole | C3H6747NS – PubChem,
Thiazole | chemical compound | Britannica