Category: 56503-96-9

Cheng, Chong-Yun published the artcileSolvent free synthesis of 2-aminothiazole derivatives under microwave irradiation, Formula: C13H10N2S, the publication is Youji Huaxue (2005), 25(7), 826-829, database is CAplus.

Nine 2-aminothiazole derivatives were obtained under microwave irradiation condition by the reaction of thiourea, iodine and ketone in the absence of solvent. The reaction conditions were optimized by orthogonal design. The mechanism of the cyclization reaction under microwave irradiation was also suggested.

Youji Huaxue published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Formula: C13H10N2S.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica

Liu, Jingbao published the artcileDesign, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors, Application In Synthesis of 56503-96-9, the publication is European Journal of Medicinal Chemistry (2012), 10-20, database is CAplus and MEDLINE.

Thirty-two substituted ethenesulfonic acid ester derivatives were designed, synthesized and evaluated for their inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) and selectivity over T-Cell protein tyrosine phosphatase (TCPTP). A preliminary structure-activity relationship studies demonstrated that the substitution at the aromatic center and the length of linker between the hydrophobic tail and aromatic center markedly affected the inhibitory activity against PTP1B and the selectivity over TCPTP. Specifically, two compounds revealed excellent inhibitory activity to PTP1B with IC₅₀ = 1.3 μM and 1.5 μM, resp. and marked 10-fold and 20-fold selectivity over TCPTP. Cytotoxicity data showed low cytotoxicity for COS-7 cell with IC₅₀ values >100 μM for most synthesized chems. The title compounds thus formed included (1E)-2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]ethenesulfonic acid Et ester (I) and related substances, such as isoxazole derivatives and thiazole derivatives The synthesis of the target compounds was achieved using 4-bromo-3-oxopentanoic acid Me ester, 4-bromo-3-oxobutanoic acid Me ester, benzamide and benzenecarbothioamide as simple starting materials.

European Journal of Medicinal Chemistry published new progress about 56503-96-9. 56503-96-9 belongs to thiazole, auxiliary class Thiazole,Amine,Naphthalene, name is 4-(Naphthalen-1-yl)thiazol-2-amine, and the molecular formula is C13H10N2S, Application In Synthesis of 56503-96-9.

Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica