Category: 57493-24-0

Zhang, Zhi-Hua; Wu, Hong-Mei; Deng, Sai-Nan; Cai, Xiao-Yu; Yao, Yu; Mwenda, Muriira Cyrus; Wang, Jin-Yin; Cai, Dong; Chen, Yu published the artcile< Design, synthesis, and anticancer activities of novel 2-amino-4-phenylthiazole scaffold containing amide moieties>, Quality Control of 57493-24-0, the main research area is morpholinoacetamido thiazolylphenyl benzamide preparation anticancer activity.

Appropriately substituted 2-amino-4-phenylthiazole derivatives I (R = 3-CH3C6H4, 4-BrC6H4, 2-furyl, cyclohexyl, CH3OCH2, ClCH2, etc.) were designed and synthesized according to the structural characteriztics of crizotinib. The target compounds I were evaluated for their in vitro antiproliferative activity against A549, HeLa, HT29, and Karpas299 human cancer cell lines. Based on results of biol. studies, some of these compounds exhibited significant antiproliferative activity. Compound I (R = 3,4-Cl2C6H3) possessed outstanding growth inhibitory effects on the four cell lines, especially for HT29 cell with IC50 value of 2.01 μM. Along with the biol. assay data, a mol. docking study suggests that the target compounds were a potential inhibitor.

Journal of Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Quality Control of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Vagadia, F. J.; Bhuva, D. A.; Jiladia, M. A. published the artcile< Synthesis and antimicrobial evaluation of some novel substituted thiazole derivatives>, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is thiazole azetidinone preparation antibacterial antifungal.

2-Aminothiazoles were prepared by condensation reaction of acetophenones and thiourea. Subsequent reaction with aromatic aldehydes gave Schiff bases, which were were cyclized with ClCH2COCl and Et3N to yield 2-azetidinones. The synthesized compounds were screened for antibacterial (E. coli, S. aureus) and antifungal (C. albicans) activity by disk diffusion and showed weak to moderate activity.

Pharma Science Monitor published new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

He, Bai; Velaparthi, Subash; Pieffet, Gilles; Pennington, Chris; Mahesh, Aruna; Holzle, Denise L.; Brunsteiner, Michael; van Breemen, Richard; Blond, Sylvie Y.; Petukhov, Pavel A. published the artcile< Binding Ensemble Profiling with Photoaffinity Labeling (BEProFL) Approach: Mapping the Binding Poses of HDAC8 Inhibitors>, Synthetic Route of 57493-24-0, the main research area is histone deacetylase HDAC8 photoaffinity labeling BEProFL.

A binding ensemble profiling with (f)photoaffinity labeling (BEProFL) approach that utilizes photolabeling of HDAC8 with a probe containing a UV-activated aromatic azide, mapping of the covalent modifications by liquid chromatog.-tandem mass spectrometry, and a computational method to characterize the multiple binding poses of the probe is described. By use of the BEProFL approach, two distinct binding poses of the HDAC8 probe were identified. The data also suggest that an “”upside-down”” pose with the surface binding group of the probe bound in an alternative pocket near the catalytic site may contribute to the binding.

Journal of Medicinal Chemistry published new progress about Enzyme functional sites. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Synthetic Route of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nath, J. P.; Dash, Manjula; Satrusallya, S. C.; Mahapatra, G. N. published the artcile< Synthesis of some 7-substituted 8-hydroxyquinoline derivatives of thiazoles and oxazoles as potential pesticides>, Safety of 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is hydroxyquinoline fungicide bactericide pesticide preparation; aminomethylhydroxyquinoline thiazolyl oxazolyl; Mannich hydroxyquinoline.

Mannich reaction of 8-hydroxyquinoline with PhCHO and I (R = H, Cl, Br; R1 = Ph, 4-ClC6H4, 4-BrC6H4, 4-HOC6H4, 4-MeO(C6H4, 3-O2NC6H4, 4-O2NC6H4, 4-MeC6H4, α-,β-naphthyl; X = O, S) gave the title compounds (II). II showed bactericidal and fungicidal activity.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Fungicides. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhu, Yan-Ping; Yuan, Jing-Jing; Zhao, Qin; Lian, Mi; Gao, Qing-He; Liu, Mei-Cai; Yang, Yan; Wu, An-Xin published the artcile< I2/CuO-catalyzed tandem cyclization strategy for one-pot synthesis of substituted 2-aminothiazole from easily available aromatic ketones/α,β-unsaturated ketones and thiourea>, Category: thiazole, the main research area is aminothiazole preparation thiourea aromatic ketone butenone cyclization.

A concise and efficient one-pot process from easily available Me ketones or unsaturated Me ketones and thiourea was developed for the synthesis of 2-aminothiazoles with I2/CuO as catalyst. The method gave the E-isomers of 4-ethenyl-2-aminothiazoles. All these target mols. were characterized by NMR, HRMS and IR spectra.

Tetrahedron published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Brito, Camila C. Bitencourt; Carneiro da Silva, Helder Vinicius; Brondani, Daci Jose; Rodolfo de Faria, Antonio; Ximenes, Rafael Matos; Mangueira da Silva, Ivanildo; de Albuquerque, Julianna F. C.; Castilho, Marcelo Santos published the artcile< Synthesis and biological evaluation of thiazole derivatives as LbSOD inhibitors>, HPLC of Formula: 57493-24-0, the main research area is thiazole derivative preparation LbSOD inhibitor Leishmaniasis; Leishmania; superoxide dismutase; thermal shift assay; thiazole derivatives.

Leishmaniasis is considered as one of the major neglected tropical diseases due to its magnitude and wide geog. distribution. Leishmania braziliensis, responsible for cutaneous leishmaniasis, is the most prevalent species in Brazil. Superoxide dismutase (SOD) belongs to the antioxidant pathway of the parasites and human host. Despite the differences between SOD of Leishmania braziliensis and human make this enzyme a promising target for drug development efforts. No medicinal chem. effort has been made to identify LbSOD inhibitors. Herein, we show that thermal shift assays (TSA) and fluorescent protein-labeled assays (FPLA) can be employed as primary and secondary screens to achieve this goal. Moreover, we show that thiazole derivatives bind to LbSOD with micromolar affinity.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Leishmaniasis. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, HPLC of Formula: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Muthyala, Manoj Kumar; Kumar, Anil published the artcile< A novel and efficient one pot synthesis of 2,4-disubstituted thiazoles and oxazoles using phenyltrimethylammonium tribromide in ionic liquid>, COA of Formula: C9H7N3O2S, the main research area is amide ketone cyclization phenylmethylammonium tribromide ionic liquid; urea ketone cyclization phenylmethylammonium tribromide ionic liquid; oxazole green preparation; thiazole green preparation.

A novel and efficient 1-pot procedure was described for synthesis of 2,4-disubstituted thiazoles and oxazoles from substituted ketones using phenyltrimethylammonium tribromide as in-situ brominating agent followed by reaction with thioamide/thiourea and amides/ureas, resp. in [bmim][BF4] ionic liquid The advantages of the procedure include avoiding the handling of lacrymetric compounds and hazardous and toxic organic solvents along with good to excellent yields of the products.

Journal of Heterocyclic Chemistry published new progress about Cyclization. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, COA of Formula: C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Dutta, Satyajit; Mariappan, G.; Asada, R. K.; Bhuyan, N. R.; Mohanty, J. P. published the artcile< Synthesis and antimicrobial evaluation of aminophenylthiazole derivatives>, COA of Formula: C9H7N3O2S, the main research area is acetophenone thiourea cyclocondensation; amino aryl thiazole preparation antibacterial antifungal.

A new series of 2-aminophenylthiazole derivatives was synthesized and structures were confirmed on the basis of IR, 1H-NMR spectroscopic data. The compounds were screened for antimicrobial activity in vitro by Kirby-Bauer disk diffusion method and the compounds 2-amino-4-(3-nitro/4-chlorophenyl)phenylthiazoles showed promising activity.

Pharma Chemica published new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, COA of Formula: C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kearney, Patrick C.; Fernandez, Monica; Flygare, John A. published the artcile< Traceless Solid-Phase Synthesis of 2-Aminothiazoles>, Synthetic Route of 57493-24-0, the main research area is thiazolamine derivative preparation solid phase; ketone bromo cyclocondensation resin bound thiourea.

2-Aminothiazoles are produced under mild conditions in good yields and with high degrees of purity from a primary amine and an α-bromo ketone. The key to this method is the conversion of a resin-bound amino group to a thiourea using Fmoc-NCS.

Journal of Organic Chemistry published new progress about Cyclocondensation reaction. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Synthetic Route of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lakhan, R.; Rai, B. J. published the artcile< Local anesthetics. IV. Synthesis and activity of 2-(N-substituted or N,N-disubstituted aminoacetamido)-4- or -4,5-substituted thiazoles>, Safety of 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is local anesthetic aminoacetamidothiazole preparation; thiazole aminoacetamido anesthetic preparation.

I (R = H or Me, R1 and R2 = H or alkyl or NR1R2 = morpholino, R3 = H or m- or p-O2N) were prepared by treatment of the appropriate 2-chloroacetamidothiazole derivative with an appropriate amine. I(R = H, R1 = R2 = iso-Pr, R3 = m-O2N) [105602-34-4] and I (R = Me, R1 = R2 = Pr, R3 = H) [105602-33-3] (as HCl salt) were the most potent local onesthetics in comparison with procaine-HCl. All other I required a similar time n producing onset of anesthesia as procaine.

Farmaco, Edizione Scientifica published new progress about Local anesthetics. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica