Category: 57493-24-0

Rezania, Jafar; Behzadi, Hadi; Shockravi, Abbas; Ehsani, Morteza; Akbarzadeh, Elahe published the artcile< Synthesis and DFT calculations of some 2-aminothiazoles>, Name: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is aminothiazole preparation green chem DFT calculation; ketone aryl thiourea cyclization iodine catalyst.

A series of 2-aminothiazole derivatives I (R = C6H5, 3-pyridyl, 3-O2NC6H4, etc.) has been synthesized by the reaction of acetyl compounds RC(O)CH3 with thiourea and iodine as catalyst under solvent-free condition, a green chem. method. The quantum chem. calculations at the DFT/B3LYP level of theory in gas phase were carried out for starting acetyl derivatives The HOMO and LUMO and related reactivity descriptor of acetyl derivatives, as well as, enthalpy of reactions are calculated in order to investigate the reaction properties of acetyl compounds and yields of the reactions. The calculated reactivity descriptors are well correlated to activity of different acetyl derivatives

Journal of Molecular Structure published new progress about Alkyl aryl ketones Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Name: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kozikowski, Alan P.; Chen, Yufeng; Gaysin, Arsen M.; Savoy, Doris N.; Billadeau, Daniel D.; Kim, Ki Hwan published the artcile< Chemistry, biology, and QSAR studies of substituted biaryl hydroxamates and mercaptoacetamides as HDAC inhibitors-nanomolar-potency inhibitors of pancreatic cancer cell growth>, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is histone deacetylase inhibitor biaryl hydroxamate mercaptoacetamide preparation QSAR; pancreatic cancer inhibitor biaryl hydroxamate mercaptoacetamide preparation QSA.

The histone deacetylases (HDACs) are able to regulate gene expression, and inhibitors of the HDACs (HDACIs) hold promise in the treatment of cancer as well as a variety of neurodegenerative diseases. To investigate the potential for isoform selectivity in the inhibition of HDACs, we prepared a small series of 2,4′-diaminobiphenyl ligands functionalized at the para-amino group with an appendage containing either a hydroxamate or a mercaptoacetamide group and coupled to an amino acid residue at the ortho-amino group. A smaller series of substituted phenylthiazoles was also explored. Some of these newly synthesized ligands show low-nanomolar potency in HDAC inhibition assays and display micromolar to low-nanomolar IC50 values in tests against five pancreatic cancer cell lines. The isoform selectivity of these ligands for class I HDACs (HDAC1-3 and 8) and class IIb HDACs (HDAC6 and 10) together with QSAR studies of their correlation with lipophilicity are presented. Of particular interest is the selectivity of the mercaptoacetamides for HDAC6.

ChemMedChem published new progress about Antitumor agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Uppal, Archana; Kothiyal, Preeti; Singh, Anita published the artcile< Hybrid Class Phenylthiazole and 1,2,3,4-Tetrahydronaphthalene Target Sertraline Transporter for Antidepressant Action Revealed by Molecular Docking Studies>, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is phenylthiazolyltetrahydronaphthalene derivative preparation antidepressant activity; epoxytetrahydronaphthalene preparation amine addition.

Phenylthiazolyl-substituted 1,2,3,4-tetrahydronaphthalene derivatives e. g., I, were synthesized, and their chem. structures were elucidated by Fourier transform IR, 1H-NMR, 13C-NMR spectral data and elemental analyses. Antidepressant-like activities of these compounds were screened using both Porsolt’s behavioral despair on albino mice and tail suspension tests. Open field test was also performed for the examination of probable neurol. deficits, which may interfere with the test results. The test compounds exhibited different levels of antidepressant activities. Addnl., the key ligand was further substantiated by docking experiment to explore plausible mode of binding in mol. dynamics overflow. The studies elucidates role of a hydrophilic H-bonding region and pi-cation binding as a major driving force for biol. activity.

Journal of Heterocyclic Chemistry published new progress about Addition reaction. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Al-Shamkhani, Zeki A. Naser; Al-Hazam, Hanan A. published the artcile< Microwave Assisted Synthesis, Characterizations and Antibacterial Activity of Some of Thiazole Derivatives>, Quality Control of 57493-24-0, the main research area is thiazole amino preparation antibacterial microwave.

A series of substituted 2-amino thiazole compounds I (R = H, 4-OH, 2-F, etc.) were synthesized by reaction of substituted acetophenone with thiourea and iodine in microwave oven. The biol. screening data of the synthesized compounds I were also studied.

Research Journal of Pharmaceutical, Biological and Chemical Sciences published new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Quality Control of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Hosseini-Sarvari, Mona; Hosseinpour, Zeinab; Koohgard, Mehdi published the artcile< Visible light thiocyanation of N-bearing aromatic and heteroaromatic compounds using Ag/TiO2 nanotube photocatalyst>, Safety of 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is aryl thiocyanate preparation green chem visible light irradiation; pyrrole aniline aminothiazole thiocyanation photocatalyst.

In this study, Ag/TiO2 nanotubes (Ag/TNT) were synthesized via simple hydrothermal process, and this photocatalyst was successfully exploited in thiocyanation reactions at room temperature under visible light irradiation Four classes of important heterocyclic compounds including indole, aniline, pyrrole and 2-aminothiazole derivatives via Ag/TNT treated with ammonium thiocyanate formed the corresponding thiocyano compounds in moderate to excellent yields. Plasmonic property and catalytic performance of Ag nanoparticles (which mainly deposited on the surface of TNT) in absorbing species containing sulfur atoms were key components for the reactions to proceed. This potent, simple and versatile protocol reported for the first time afforded thiocyanation reactions of aniline, pyrrole and 2-aminothiazole derivatives under visible light. The reactions proceeded through a radical pathway by applying air mol. oxygen as a low-cost and environmentally friendly terminal oxidant.

New Journal of Chemistry published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Javadi, Ali; Shockravi, Abbas; Shourkaei, Fateme Ahmadi; Koohgard, Mehdi; Malek, Ali published the artcile< Highly refractive thiazole-containing polyimides: a structural property comparison>, Product Details of C9H7N3O2S, the main research area is thiazole containing polyimide structural thermal property.

Highly refractive, thermally stable, and solution processable polyimides (PIs) were synthesized by the introduction of thiazole units, thioether linkages, and Ph or nitrophenyl groups into the polymer backbones. These PIs were prepared via the polycondensation of two diamine monomers, 5,5′-thiobis(2-amino-4-phenyl-thiazole) (DA-1) or 5,5′-thiobis(2-amino-4-(3-nitrophenyl)thiazole) (DA-2), with various aromatic dianhydrides (a-d). The bulky pendant Ph or nitrophenyl units as well as the non-coplanar conformations because of ortho-sulfide linkages endowed the resulting PIs with excellent solubility in organic solvents. These PIs showed outstanding thermal stability, with 10% weight loss temperatures exceeding 492 °C under nitrogen and 475 °C in air atm., while their glass transition temperatures were in the range of 239-278 °C. In general, the synergic effects of thiazole groups, Ph or nitrophenyl substituents, and thioether linkages provided PIs with very high refractive indexes of up to 1.7646 at 632.8 nm, along with small birefringences (<0.0085) and high Abbe's numbers The structure-property relationships of the analogous PIs containing Ph or nitrophenyl substituents groups were also studied in detail by comparing the results. Journal of Polymer Research published new progress about Chars. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Product Details of C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Karade, Hitendra; Sathe, Manisha; Kaushik, M. P. published the artcile< An efficient method for the synthesis of 2-aminothiazoles using silica chloride as a heterogeneous catalyst>, Category: thiazole, the main research area is aminothiazole preparation ketone thiourea silica chloride catalyst; thiazole amino preparation ketone thiourea silica chloride catalyst.

Preparation of 2-aminothiazoles under mild reaction conditions with quant. yields using silica chloride as an effective heterogeneous catalyst is reported.

Catalysis Communications published new progress about Cyclization. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nizamuddin, Nd; Abdul ahad, Hindustan; Devanna, Nayakanti published the artcile< Molecular docking studies of N-methyl- 2, 3 -disubstituted quinazolin-4-ones scaffold>, SDS of cas: 57493-24-0, the main research area is methyl disubstituted quinazolinone scaffold mol docking.

In recent days, synthesis of anticancer mols. having both low adverse effects and specific protein targeting are seldom. Synthesis of anticancer mols. having both low adverse effects and specific protein targeting is challenging. The main objective of our study was to develop mols. that can target activated protein kinase P38 alpha and activin receptor (ALK2) kinase for treating carcinoma. P38 alpha is involved in cell differentiation, apoptosis, and autophagy. Activin receptor (ALK2) kinase is responsible for mutations of cancerous cells. The synthesis of N-Me – 2, 3 -Disubstituted Quinazolin-4-Ones was carried out by refluxing of 1-methyl-2-(pyridinyl)-1,2-dihydro-4H-3,1-benzoxazin-4-one with 4-substituted phenyl-1,3-thiazol-2-amines. The mol. docking of 1-methyl-3-(4-substituted phenyl-1,3-thiazol-2-yl)-2-(pyridin-3-yl)-2,3-dihydroquinazolin-4(1H)-one (5Da1-5Dk11) and 1-methyl-3-(4-substituted phenyl-1,3-thiazol-2-yl)-2-(pyridin-4-yl)-2,3-dihydroquinazolin-4(1H)-one (5Ea1-5Ek11) derivatives were carried out using Schrodinger Glide (version 2020_1) software. Twenty-two quinazoline-4-one derivatives were docked into selective P38 alpha and ACVR1 (ALK2) kinase with PDB code 3GC7, 6GI6. Based on the docking score, comparison between quinazolin-4-one derivatives, co-crystallized Ligands interaction was evaluated using 5-Fluorouracil as standard Best activity was found in compounds 5Df6, 5Dd4, 5Ed4 and 5Ef6 with ACVR1 (ALK2) kinase with score of -8.223, -7.936, -8.123, -7.907 and 5Df6, 5Dh8, 5Eb2 and 5Ee5 with P38alpha with score of -7.19, -7.027, -6.698, -6.789 Kcal/mol against enzymes responsible for treatment for cancer compare with reference drug score -5.765 and -6.195. This study will help in the design and development of a drug that gives room for the synthesis of a new selective ACVR1 (ALK2) kinase and P38alpha enzyme inhibitor with predetermined affinity and activity of the compound

International Journal of Life Science and Pharma Research published new progress about Activin receptor ACVRLK2 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Uppal, Archana; Singh, Anita; Kothiyal, Preeti published the artcile< Structure-based design, synthesis and antidepressant-like activity of phenylthiazolyl-1H,2H,3H,4H-naphthalene derivatives>, Related Products of 57493-24-0, the main research area is aryl thiazolyl amino tetrahydronaphthalene preparation mol docking antidepressant.

A series of new [aryl(thiazolyl)]aminotetrahydronaphthalene derivatives I [R1 = H, OMe, Cl; R2 = H, Me; R3 = 4-CH3, 3,4-di-Cl, 4-Br, etc.] were synthesized and studied for their mol. docking properties via in silico assay in CHARMm-based CDocker program. Results indicated that these compounds showed interactions towards serotonin transporters. All the titled compounds were evaluated for antidepressant activity by forced-swimming test, tail suspention test and open-field test on albino mice and acute toxicity of compounds I [R1 = OMe; R2 = H; R3 = 4-NHC(O)CH3, 3-NO2] were also studied. Antidepressant-like effect in mice tests revealed that the most active compounds were I [R1 = OMe; R2 = H; R3 = 4-NHC(O)CH3, 3-NO2] with no any toxicity.

Asian Journal of Chemistry published new progress about Antidepressants. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Related Products of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Muthal, Bn published the artcile< Transition metal ion CoII, NiII, CuII & ZnII complexes of tridentate ligands (NNO) their synthesis, characterization and biological activities>, Formula: C9H7N3O2S, the main research area is nitrophenylthiazole hydroxybenzylideneimine transition metal Schiff base preparation antibacterial antifungal.

A series of new Schiff bases were synthesized by combination of 4(-3-nitrophenyl) thiazol-2-amine with hydroxy aldehyde (R-H, 5CH3 and 5Cl). Schiff bases and their transition metal complexes where characterized by elemental anal., UV-visible, IR spectra, magnetic susceptibility and conductivity measurement. The transition metal complexes are monomeric and 1:2 stoichem. having octahedral geometry. The ligands coordinated through oxygen atom of phenolic -OH group and also from thiazole ring nitrogen. The Schiff bases and their metal complexes were screen for antibacterial and antifungal activity.

Pharma Innovation published new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Formula: C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica