Category: 57493-24-0

Wang, Xingyi; Zhu, Yue; Zhou, Tingting; Yang, Weiqing; Fu, Haiyan; Chen, Hua; Ma, Menglin published the artcile< Bromine-Mediated C-S Bond Formation: Synthesis of Thiazoles from α-Methylene Ketones by Using Oxone Oxidative System>, SDS of cas: 57493-24-0, the main research area is ethanone methanethioamide sodium bromide catalyst one pot bromination heterocyclization; thiazole preparation.

A novel method for the synthesis of various 2,4,5-trisubstituted thiazoles from methylketones and thiourea/thioacetamide/amidinothiourea using NaBr/Oxone oxidative system was developed. The three intimately connected advantages of this method, which form a whole, are that the reaction underwent a one-pot α-bromination/cyclization process, the use of more common methylene ketones as the raw material rather than α-halomethylene ketones and a cheap and easily available catalytic amount sodium bromide as the bromine source instead of stoichiometric bromine or NBS.

ChemistrySelect published new progress about C-S bond formation. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shah, Mayuri Nilesh; Joshi, Vidya published the artcile< Synthesis of substituted N-(3,5-dimethoxyphenyl/ styryl)-N1-(thiazol-2-yl)ureas>, SDS of cas: 57493-24-0, the main research area is thiazolylurea styryl dimethoxyphenyl; urea thiazolyl.

4-Substituted 2-aminothiazoles, obtained by condensation of substituted ω-bromoacetoketones with thiourea, on reaction with 3,5-dimethoxyphenyl isocyanate gave new N-(3,5-dimethoxyphenyl)-N1-(4-substituted thiazol-2-yl)ureas, e.g. I. Similarly, the 4-substituted 2-aminothiazoles on treatment with styryl isocyanate gave N-styryl-N1-(4-substituted thiazol-2-yl)ureas, e.g. II.

Indian Journal of Heterocyclic Chemistry published new progress about 57493-24-0. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kamble, Sonali S.; Hese, Shrikant V.; Dawane, Bhaskar S.; Gacche, Rajesh N. published the artcile< Anti-breast cancer and antiangiogenic potential of substituted thiazolo[2,3-b] quinazoline derivatives: synthesis, in vitro and in vivo analysis>, Safety of 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is thiazolo quinazoline derivative antibreast cancer antiangiogenic potential.

Herein, a series of novel substituted thiazolo[2,3-b]quinazoline derivatives has been synthesized. The capability of the synthesized compounds 3a-i to hinder the viability of human breast cancer cell line (MCF-7) was assessed. The compounds were evaluated as possible inhibitors of angiogenesis by using in vivo chorioallantoic membrane (CAM) model. Amongst the compounds 3a-i screened, 3d and 3f exhibited excellent cytotoxicity with IC50 values 6.0±0.03μM & 5.0±0.36μM resp. Compounds were further tested to evaluate potential to inhibit the pro-angiogenic cytokines associated with tumor development. Both the compounds were found to be potent antiangiogenic agents against VEGF, TNFa, IL6, TGFb, and EGF. The outcome of the present study reveals that, compound 3d and 3f showed the promising inhibitory activity on the viability of MCF-7 cells. In the in vivo CAM model, treatment with all the compounds resulted in the significant decrease in blood vessels d. The findings of the study suggest that, compounds 3d & 3f may act as potential anti-breast cancer and antiangiogenic agents.

Chemistry & Biology Interface published new progress about Angiogenesis. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Hebade, Madhav J.; Kamble, Rahul D.; Hese, Shrikant V.; Mogle, Pratima P.; Ambhore, Ajay N.; Kadam, Shuddhodan N.; Dawane, Bhaskar S. published the artcile< A rapid, mild, and efficient method for C-5 iodination/thiocyanation of 2-aminothiazoles>, HPLC of Formula: 57493-24-0, the main research area is green multitasking substitution iodination thiocyanation aminothiazole; iodo aminothiazole green preparation iodination; thiocyano aminothiazole green preparation thiocyanation.

An efficient, green, rapid multitasking protocol for the selective C-5 substitution of 2-aminothiazole using iodic acid and aqueous PEG-400 was developed. The method found suitable for C-5 substitution i.e. iodination and thiocyanation of 2-amino thiazole using iodine and ammonium thiocyanate resp. Iodic acid was found to be a good oxidant and aqueous PEG-400 as green reaction solvent.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Cyanation, thiocyanation. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, HPLC of Formula: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Gundala, Trivikram Reddy; Godugu, Kumar; Nallagondu, Chinna Gangi Reddy published the artcile< Citric Acid-catalyzed Synthesis of 2,4-Disubstituted Thiazoles from Ketones via C-Br, C-S, and C-N Bond Formations in One Pot: A Green Approach>, Name: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is citric acid thiazole ketone chromatog one pot synthesis.

An improved and greener protocol has been developed for the synthesis of 2,4-disubstituted thiazoles via C-Br, C-S, and, C-N bond formations in a single step from readily available ketones, N-bromosuccinimide (NBS), and thiourea catalyzed by citric acid in a mixture of ethanol and water (3:1) under reflux conditions. This method has the advantages of freedom from the isolation of lachrymatory α-bromoketones, ease of carrying out, cleaner reaction profile, broad substrate scope, freedom from chromatog. purification, and suitability for large-scale synthesis.

Journal of the Chinese Chemical Society (Weinheim, Germany) published new progress about Chromatography. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Name: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhang, Xiaolin; Yang, Hongxia Ou; Ding, Yonghong published the artcile< The synthesis and characterization of potential novel active compounds, 2-aminothiazole derives Schiff bases>, Safety of 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is aromatic ketone thiourea cyclocondensation; aminothiazole preparation condensation aryl aldehyde; Schiff base preparation.

Some 4-substituted-2-aminothiazoles were prepared starting from aromatic ketones and thiourea in the presence of powered iodine. Then treating 4-substituted-2-aminothiazole with substituted benzaldehyde gave corresponding 2-aminothiazole derivatives Schiff bases in good yield.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroaryl). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Shruthy, V. S.; Yusuf, Shakkeela published the artcile< In silico design, docking, synthesis and evaluation of thiazole Schiff bases>, Formula: C9H7N3O2S, the main research area is thiazole Schiff base preparation antiinflammatory anticancer protein kinase docking; cinnamaldehyde thiazole condensation.

A series of substituted Schiff base derivatives of 4-Ph thiazoles designed as anticancer and anti-inflammatory agents using computational methods was synthesized. The thiazole derivatives were selected based on docking studies performed on active site of protein tyrosine kinase (PDB :1T46) for anticancer activity and protein kinase (PDB :3DPK) for anti-inflammatory activity using Schrodinger 9.3 software. Mols. with better docking score was subjected to anal. for cytotoxic activity by in vitro MTT assay on cervical cancer HeLa cell lines and anti-inflammatory activity. Among the five thiazole derivatives, (4-(4-Methoxyphenyl)-N-3-phenylprop-2-en-1-ylidene-1,3-thiazol-2-amine) was found to have highest docking score and the same exhibited maximum in vitro cytotoxic and antiinflammatory activity. Thiazole schiff bases derivatives showed good antinflammatory and cytotoxic activity as predicted using mol. docking on resp. receptors.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about Anti-inflammatory agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Formula: C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Mishra, Deepak; Fatima, Atiya; Rout, Chittaranjan; Singh, Ram published the artcile< An efficient one-pot synthesis of 2-aminothiazole derivatives>, Electric Literature of 57493-24-0, the main research area is aminothiazole preparation; haloketone thioamide cyclization.

A highly efficient, rapid and catalyst free protocol has been developed for the synthesis of 2-aminothiazoles I (R = Br, NO2, OCH3, etc.; R1 = Cl, CN, OCH3, etc.) in THF. Reaction was carried out at room temperature and the products were obtained in high yields without further purification

Chemica Sinica published new progress about Cyclization. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Electric Literature of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Gromek, Samantha M.; deMayo, James A.; Maxwell, Andrew T.; West, Ashley M.; Pavlik, Christopher M.; Zhao, Ziyan; Li, Jin; Wiemer, Andrew J.; Zweifach, Adam; Balunas, Marcy J. published the artcile< Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity>, SDS of cas: 57493-24-0, the main research area is santacruzamate A analog preparation antiproliferative immunomodulator; Anti-proliferative activity; Enzyme assays; Immune modulation; Natural product analogues; Santacruzamate A.

Santacruzamate A (SCA) is a natural product isolated from a Panamanian marine cyanobacterium, previously reported to have potent and selective histone deacetylase (HDAC) activity. To optimize the enzymic and cellular activity, 40 SCA analogs were synthesized in a systematic exploration of the zinc-binding group (ZBG), cap terminus, and linker region. Two cap group analogs inhibited proliferation of MCF-7 breast cancer cells, with analogous increased degranulation of cytotoxic T cells (CTLs), while one cap group analog reduced CTL degranulation, indicative of suppression of the immune response. Addnl. testing of these analogs resulted in reevaluation of the previously reported SCA mechanism of action. These analogs and the resulting structure-activity relationships will be of interest for future studies on cell proliferation and immune modulation.

Bioorganic & Medicinal Chemistry published new progress about Antiproliferative agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Gorji, Samareh; Ghorbani-Vaghei, Ramin; Alavinia, Sedigheh published the artcile< Sodium alginate: Biopolymeric catalyst for the synthesis of 2-amino-4-arylthiazole derivatives in aqueous medium>, Synthetic Route of 57493-24-0, the main research area is aryl alkyne thiourea sodium alginate catalyst heterocyclization; amino arylthiazole preparation green chem.

An efficient and recoverable bifunctional heterogeneous organocatalyst for the synthesis of 2-amino-4-arylthiazole derivatives was carried out by the reaction of substituted Ph acetylene and thiourea in an eco-friendly condition in the presence of TBBDA. Mild reaction conditions, simple reaction procedure, easy purification, high yields of products, eco-friendly catalyst usage and convenient reusability were the highlighted points of this protocol.

Journal of Molecular Structure published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Synthetic Route of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica