Category: 57493-24-0

Chen, Lingfeng; Chen, Hongjin; Chen, Pengqin; Zhang, Wenxin; Wu, Chao; Sun, Chuchu; Luo, Wu; Zheng, Lulu; Liu, Zhiguo; Liang, Guang published the artcile< Development of 2-amino-4-phenylthiazole analogues to disrupt myeloid differentiation factor 88 and prevent inflammatory responses in acute lung injury>, Name: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is piperazinyl phenylthiazolylpropanamide preparation MyD88 protein homodimerization inhibitor antiinflammatory; 2-Amino-4-phenylthiazole; Acute lung injury; Anti-inflammation; Macrophages; MyD88.

The synthesis of 47 new analogs by modifying different sites on this lead compound and assessed their anti-inflammatory activities in lipopolysaccharide-induced mouse primary peritoneal macrophages (MPMs) was described. The most promising compound I was found to effectively interact with MyD88 protein and prevented formation of the MyD88 homodimeric complex. Furthermore, compound I showed in-vivo anti-inflammatory activity in LPS-caused model of acute lung injury. This work provided new candidates as MyD88 inhibitors to combat inflammation diseases.

European Journal of Medicinal Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Name: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhou, Renwu; Zhou, Rusen; Zhang, Xianhui; Fang, Zhi; Wang, Xiaoxiang; Speight, Robert; Wang, Hongxia; Doherty, William; Cullen, Patrick J.; Ostrikov, Kostya; Bazaka, Kateryna published the artcile< High-Performance Plasma-Enabled Biorefining of Microalgae to Value-Added Products>, Safety of 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is microalgae biorefining high performance plasma; biomass; biorefining; liquefaction; microalgae; plasma chemistry.

Conversion of renewable biomass by time- and energy-efficient techniques remains an important challenge. Herein, plasma catalytic liquefaction (PCL) is employed to achieve rapid liquefaction of microalgae under mild conditions. The choice of the catalyst affects both the liquefaction efficiency and the yield of products. The acid catalyst is more effective and gave a liquid yield of 73.95 wt % in 3 min, as opposed to 69.80 wt % obtained with the basic catalyst in 7 min. Analyses of the thus-formed products and the processing environment reveal that the enhanced PCL performance is linked to the rapid increase in temperature under the effect of plasma-induced elec. fields and the generation of large quantities of reactive species. Moreover, the obtained solid residue can be simply upgraded to a carbon product suitable for supercapacitor applications. Therefore, the proposed strategy may provide a new avenue for fast and comprehensive utilization of biomass under benign conditions.

ChemSusChem published new progress about Alcohols Role: IMF (Industrial Manufacture), PREP (Preparation). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Akbarzadeh, Elaheh; Shockravi, Abbas; Vatanpour, Vahid published the artcile< High performance compatible thiazole-based polymeric blend cellulose acetate membrane as selective CO2 absorbent and molecular sieve>, Synthetic Route of 57493-24-0, the main research area is thiazole cellulose acetate polymeric blend membrane selective absorption property; CO(2) capture; Cellulose acetate (CA); Gas separation; Permeation; Polymeric blend membrane; Thiazole.

Green blend membranes comprise of high thermal resistance ortho-linked thiazole-based polyimine (PM-4) including thioether linkage were fabricated in combination of glassy cellulose acetate (CA). The thermal stabilities of PMs were examined using thermogravimetric anal. and differential scanning calorimetry. Morphol. aspects and functional groups of the membranes were investigated via field emission SEM and Fourier transform IR spectroscopy-attenuated total reflectance anal. resp. X-ray diffraction and mech. strength were determined as well. The effects of polyimine content, pressure and temperature were studied on CO2 permeability (P) and selectivity. The pressure changes revealed exponentially increases on CO2 permeability by plasticization, facilitated transfer and solution-diffusion mechanisms, but decreases on CH4 and N2 permeations. Remarkable permeation (P = 3000 Barrer) of CA/PM-4 (1:3% weight/weight) and ideal selectivity ratios of CO2/N2 = 59, CO2/CH4 = 33.7 were obtained at 3 bar and 35°C vs. neat CA membrane.

Carbohydrate Polymers published new progress about Absorbents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Synthetic Route of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ogretir, Cemil; Demirayak, Seref; Duran, Murat published the artcile< Spectroscopic Determination and Evaluation of Acidity Constants for Some Drug Precursor 2-Amino-4-(3- or 4-substituted phenyl) Thiazole Derivatives>, Related Products of 57493-24-0, the main research area is spectroscopic determination acidity constant drug precursor amino phenyl thiazole.

Acid dissociation constants, Ka, of eight drug precursor 2-amino-4-(3- or 4-substituted phenyl) thiazole derivatives were determined using a UV-vis spectroscopic technique. The obtained Ka values were evaluated by structure elucidation and a protonation mechanism. The obtained tautomerization equilibrium constants, KT, indicated the predominance of amino forms for all studied compounds

Journal of Chemical & Engineering Data published new progress about Bond angle, dihedral. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Related Products of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nagaladinne, Nizamuddin; Abdul Ahad, Hindustan; Nayakanti, Devanna published the artcile< Design, synthesis and molecular modelling studies of 1-methyl-3-(4-substituted phenyl-1,3- thiazol-2-yl)-2-(pyridin-3-yl)-2,3-dihydroquinazolin-4(1H)-ones as potent anticancer agents>, Product Details of C9H7N3O2S, the main research area is methyl phenyl thiazolyl pyridinyl dihydroquinazolinone preparation antitumor SAR ADMET; mol modeling methyl phenyl thiazolyl pyridinyl dihydroquinazolinone preparation.

The present study involved the design, synthesis, characterization and mol. docking studies of biol. active 1-methyl-3-(4-substituted phenyl-1,3-thiazol-2-yl)-2-(pyridin-3-yl)-2,3-dihydroquinazoline-4-(1H)-ones I [R = 2-OH, 3-NH2, 4-Cl, etc.] which were synthesized by condensation of 2-amino-4-substituted phenylthiazoles with N-methylbenzoxazin-4-one. The N-methylbenzoxazin-4-one and 2-amino-4-substituted phenylthiazoles were synthesized from N-methylanthranilic acid with pyridine3-carboxylic acid and substituted aldehydes with thiourea, resp. The ADME properties determined the synthetic accessibility of compounds I by in silico Swiss ADME. The colorectal anticancer screening of compounds I was done by using cell HT-29 human colorectal adenocarcinoma based on mol. docking studies on 3GC7-the structure of p38alpha in complex with dihydroquinazolinone. Finally, compounds I [R = 4-Me, 3-NH2, 2,4-(OH)2, 2,4-(Cl)2] exhibited better activity at a concentration < 10μg/mL when compared to 5-fluorouracil. The ADME properties revealed that all the compounds I were within the range and docking studies showed the highest binding with glide score -7.19 and -7.027 Kcal/mol compared to the target protein -10.67 Kcal/mol. Asian Journal of Chemistry published new progress about Antitumor agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Product Details of C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Javadi, Ali; Shockravi, Abbas; Koohgard, Mehdi; Malek, Ali; Shourkaei, Fateme Ahmadi; Ando, Shinji published the artcile< Nitro-substituted polyamides: A new class of transparent and highly refractive materials>, Product Details of C9H7N3O2S, the main research area is nitro polyamide transparent refractive material.

High-refractive-index polyamides (PAs) were developed by introducing nitro groups, thiazole rings, and thioether linkages. The PAs were prepared by the polycondensation of a novel diamine monomer, 5,5′-thiobis(2-amino-4-(3-nitrophenyl)thiazole) (DA), with various aromatic diacids. The bulky pendant nitrophenyl units, as well as the flexible thioether linkage in the diamine, endowed the resulting PAs with excellent solubilities in both amide-type polar aprotic solvents and less polar solvents. The obtained polymers exhibited high heat resistance, with 10% weight loss temperatures exceeding 472 °C under nitrogen and 427 °C in air atm., while their glass transition temperatures were in the range 210-244 °C. The combination of the nitro substituents, thiazole units, and thioether linkages provided PAs with high refractive indexes of up to 1.7660 at 632.8 nm, along with high transparency in the visible region and low birefringences (<0.0081). The structure-property relationships of these PAs due to the presence of nitro groups were also studied by comparing the results with the previously reported analogous polymers. European Polymer Journal published new progress about Birefringence. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Product Details of C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Malik, G. M.; Patel, Sandip K.; Patel, Pratixa K.; Zadafiya, S. K. published the artcile< Synthesis, characterization and microbial studies of 2-amino-4-(3'-nitrophenyl)thiazole based bisazo disperse dyes and their dyeing performance on polyester fibers>, COA of Formula: C9H7N3O2S, the main research area is aminonitrophenyl thiazolebisazo disperse dye polyester fiber microbial dyeing property; dyeing dye polyester fiber.

In the present study various substituted bisazo disperse dyes 2-(1′-substituted Ph azo)-4-(3′-nitrophenyl)-5-(2”,4”-dinitro Ph azo)thiazole derivatives have been synthesized using substituted 3°-amine, 2-amino-4-(3′-nitrophenyl)thiazole and 2,4-dinitroaniline. These were characterized using elemental anal., 1H NMR (NMR) and IR spectra. Their dyeing performance on polyester fiber was assessed and fastness properties of these dyes were evaluated by applying them to polyester fiber. These dyes exhibited moderate to good anti-bacterial and anti-fungal activities.

International Journal of Chemistry (Mumbai, India) published new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, COA of Formula: C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Vo, Duc Duy; Tran, Thi Phuong Anh; Staedel, Cathy; Benhida, Rachid; Darfeuille, Fabien; Di Giorgio, Audrey; Duca, Maria published the artcile< Oncogenic MicroRNAs Biogenesis as a Drug Target: Structure-Activity Relationship Studies on New Aminoglycoside Conjugates>, HPLC of Formula: 57493-24-0, the main research area is MicroRNA structure aminoglycoside antitumor neoplasm; RNA structures; biogenesis; cancer; inhibitors; microRNA.

MicroRNAs (miRNAs) are a recently discovered category of small RNA mols. that regulate gene expression at the posttranscriptional level. Accumulating evidence indicates that miRNAs are aberrantly expressed in a variety of human cancers and that the inhibition of these oncogenic miRNAs could find application in the therapy of different types of cancer. Herein, the authors describe the synthesis and biol. evaluation of new small-mol. drugs that target oncogenic miRNAs production In particular, the authors chose to target two miRNAs (i.e., miRNA-372 and -373) implicated in various types of cancer, such as gastric cancer. Their precursors (premiRNAs) are overexpressed in cancer cells and lead to mature miRNAs after cleavage of their stem-loop structure by the enzyme Dicer in the cytoplasm. Some of the newly synthesized conjugates can inhibit Dicer processing of the targeted premiRNAs in vitro with increased efficacy relative to the previous results (D.D. Vo et al., ACS Chem. Biol. 2014, 9, 711-721) and, more importantly, to inhibit proliferations of adenocarcinoma gastric cancer (AGS) cells overexpressing these miRNAs, thus representing promising leads for future drug development.

Chemistry – A European Journal published new progress about Aminoglycosides Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, HPLC of Formula: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

El-Dash, Yara; Elzayat, Emad; Abdou, Amr M.; Hassan, Rasha A. published the artcile< Novel thienopyrimidine-aminothiazole hybrids: Design, synthesis, antimicrobial screening, anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis and VEGFR-2 inhibition>, Reference of 57493-24-0, the main research area is arylthiazolyl benzothienylpyrimidinylthioacetamide preparation antitumor activity VEGFR2 inhibition; structure arylthiazolyl benzothienylpyrimidinylthioacetamide antitumor activity VEGFR2 inhibition; lack antibacterial activity arylthiazolyl benzothienylpyrimidinylthioacetamide; antifungal activity arylthiazolyl benzothienylpyrimidinylthioacetamide; Aminothiazole; Anti-proliferative; Antimicrobial activity; Cell cycle arrest profile; Phosphorylated VEGFR-2, Caspase-3; Synthesis; Thienopyrimidine; VEGFR-2.

A series of novel hybrid compounds of hexahydrobenzo[4,5]thieno[2,3-d]pyrimidine with aminothiazole scaffolds I (R = H, Br, O2N; R1 = H, Cl, Br; R2 = H, Me) were synthesized. The synthesized compounds were evaluated for their cytotoxic activity against the NCI-60 human tumor cell line panel. Compounds I (R = H; R1 = Cl; R2 = H) (II), I (R = Br; R1 = ; R2 = H) (III) and I (R = R1 = R2 = H) exhibited significant antiproliferative activities at 10-5 M dose. II exhibited excellent cytotoxic activity against CNS cancer cell lines including SNB-75 and SF-295 as well as renal cancer cell line CAKI-1 when compared with sorafenib as standard anticancer drug. In addition, III showed almost comparable anticancer activity to sorafenib against SNB-75 cell line and displayed moderate activity against SF-295 and CAKI-1 cell lines in comparison to sorafenib. II inhibited the vascular endothelial growth factor receptor 2 (VEGFR-2) with IC50 of 62.48 ± 3.7 nM and decreased both total VEGFR-2 and phosphorylated VEGFR-2 in treated SNB-75 cells suggesting its ability to down regulate cell proliferation, growth, and survival.. The flow cytometric anal. showed that II displayed its cytotoxic activity through the reduction of the cellular proliferation and induction of cell cycle arrest at the G2/M phase. II clearly boosted the level of the apoptotic caspase-3. All the synthesized compounds were also screened for their antibacterial and antifungal activity against four pathogenic strains of both Gram-pos. and Gram-neg. as well as Candida albicans. III exhibited antifungal activity against Candida albicans compared to nystatin as the standard antifungal compound

Bioorganic Chemistry published new progress about Antitumor agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Reference of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Roever, Stephan; Cesura, Andrea M.; Huguenin, Philipp; Kettler, Rolf; Szente, Andre published the artcile< Synthesis and Biochemical Evaluation of N-(4-Phenylthiazol-2-yl)benzenesulfonamides as High-Affinity Inhibitors of Kynurenine 3-Hydroxylase>, Safety of 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is phenylthiazolylbenzensulfonamide preparation kynurenine hydroxylase inhibitor; thiazolylbenzensulfonamide preparation kynurenine hydroxylase inhibitor; structure activity phenylthiazolylbenzenesulfonamide kynurenine hydroxylase inhibitor.

The synthesis, structure-activity relationship (SAR), and biochem. characterization of N-(4-phenylthiazol-2-yl)benzenesulfonamides as inhibitors of kynurenine 3-hydroxylase is described. Thiazolbenzenesulfonamides I (IC50 = 37 nM, Ro-61-8048) and and II (IC50 = 19 nM) were high-affinity inhibitors of this enzyme in vitro. In addition, both compounds blocked rat and gerbil kynurenine 3-hydroxylase after oral administration, with ED50’s in the 3-5 μmol/kg range in gerbil brain. In a microdialysis experiment in rats, I dose dependently increased kynurenic acid concentration in the extracellular hippocampal fluid. A dose of 100 μmol/kg po led to a 7.5-fold increase in kynurenic acid outflow. These new compounds should allow detailed investigation of the pathophysiol. role of the kynurenine pathway after neuronal injury.

Journal of Medicinal Chemistry published new progress about Structure-activity relationship, enzyme-inhibiting. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica