Category: 57493-24-0

Zhou, Renwu; Zhou, Rusen; Zhang, Xianhui; Fang, Zhi; Wang, Xiaoxiang; Speight, Robert; Wang, Hongxia; Doherty, William; Cullen, Patrick J.; Ostrikov, Kostya; Bazaka, Kateryna published the artcile< High-Performance Plasma-Enabled Biorefining of Microalgae to Value-Added Products>, Application In Synthesis of 57493-24-0, the main research area is microalgae biorefining high performance plasma; biomass; biorefining; liquefaction; microalgae; plasma chemistry.

Conversion of renewable biomass by time- and energy-efficient techniques remains an important challenge. Herein, plasma catalytic liquefaction (PCL) is employed to achieve rapid liquefaction of microalgae under mild conditions. The choice of the catalyst affects both the liquefaction efficiency and the yield of products. The acid catalyst is more effective and gave a liquid yield of 73.95 wt % in 3 min, as opposed to 69.80 wt % obtained with the basic catalyst in 7 min. Analyses of the thus-formed products and the processing environment reveal that the enhanced PCL performance is linked to the rapid increase in temperature under the effect of plasma-induced elec. fields and the generation of large quantities of reactive species. Moreover, the obtained solid residue can be simply upgraded to a carbon product suitable for supercapacitor applications. Therefore, the proposed strategy may provide a new avenue for fast and comprehensive utilization of biomass under benign conditions.

ChemSusChempublished new progress about Alcohols Role: IMF (Industrial Manufacture), PREP (Preparation). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Application In Synthesis of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Singh, Kamaljit; Singh, Sarbjit; Taylor, John A. published the artcile< Monoazo disperse dyes-part 1: synthesis, spectroscopic studies and technical evaluation of monoazo disperse dyes derived from 2-aminothiazoles>, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is aminothiazole diazo aminoacetanilide coupling component disperse azo dye; polyester fabric disperse dyeing thiadiazole azo dye preparation.

Novel disperse dyes have been prepared from thiazolyl diazonium salts and coupling components based on m-aminoacetanilide derivatives Depending upon various substituents incorporated into the chromophore, absorption maxima varied from 495 to 591 nm in various organic solvents. These dyes were chromophorically strong as evidenced both by molar extinction coefficient in solvent and by strength and build-up on polyester.

Dyes and Pigmentspublished new progress about Disperse azo dyes. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Recommanded Product: 2-Amino-4-(3-nitrophenyl)thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhu, Yan-Ping; Yuan, Jing-Jing; Zhao, Qin; Lian, Mi; Gao, Qing-He; Liu, Mei-Cai; Yang, Yan; Wu, An-Xin published the artcile< I2/CuO-catalyzed tandem cyclization strategy for one-pot synthesis of substituted 2-aminothiazole from easily available aromatic ketones/α,β-unsaturated ketones and thiourea>, SDS of cas: 57493-24-0, the main research area is aminothiazole preparation thiourea aromatic ketone butenone cyclization.

A concise and efficient one-pot process from easily available Me ketones or unsaturated Me ketones and thiourea was developed for the synthesis of 2-aminothiazoles with I2/CuO as catalyst. The method gave the E-isomers of 4-ethenyl-2-aminothiazoles. All these target mols. were characterized by NMR, HRMS and IR spectra.

Tetrahedronpublished new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, SDS of cas: 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Al-Shamkhani, Zeki A. Naser; Al-Hazam, Hanan A. published the artcile< Microwave Assisted Synthesis, Characterizations and Antibacterial Activity of Some of Thiazole Derivatives>, Computed Properties of 57493-24-0, the main research area is thiazole amino preparation antibacterial microwave.

A series of substituted 2-amino thiazole compounds I (R = H, 4-OH, 2-F, etc.) were synthesized by reaction of substituted acetophenone with thiourea and iodine in microwave oven. The biol. screening data of the synthesized compounds I were also studied.

Research Journal of Pharmaceutical, Biological and Chemical Sciencespublished new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Computed Properties of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Banerjee, Janmajoy; Mariappan, G.; Nepal, Aswini Kumar; Dahal, Prassana; Khanal, Hemanta published the artcile< Conventional methods of synthesis of novel amino(phenyl)thiazoles and their antibacterial and local anesthetics screening>, COA of Formula: C9H7N3O2S, the main research area is acetamide thiazolylamino preparation anesthetic antibacterial.

Cyclocondensation of thiourea and substituted acetophenones RCOMe [R = Ph, 3-O2NC6H4, 4-O2NC6H4, 4-MeOC6H4, 2,5-(MeO)2C6H3] led to the formation of the corresponding 2-amino-4-R-thiazoles, which on further reaction with N-Ph 2-chloroacetamide gave N-Ph (thiazolylamino)acetamides I. The synthesized compounds I were investigated for their antibacterial activity by cup plate method against four bacterial strains. All the synthesized compounds exhibited mild to good antibacterial activities with I [R = 2,5-(MeO)2C6H3] showing promising activity against all strains of bacteria. The compounds I were also screened for local anesthetics activity taking lidocaine as standard, and all the compounds showed moderate activities.

International Journal of Pharmacy and Technologypublished new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, COA of Formula: C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhang, Zhi-Hua; Wu, Hong-Mei; Deng, Sai-Nan; Cai, Xiao-Yu; Yao, Yu; Mwenda, Muriira Cyrus; Wang, Jin-Yin; Cai, Dong; Chen, Yu published the artcile< Design, synthesis, and anticancer activities of novel 2-amino-4-phenylthiazole scaffold containing amide moieties>, Application of C9H7N3O2S, the main research area is morpholinoacetamido thiazolylphenyl benzamide preparation anticancer activity.

Appropriately substituted 2-amino-4-phenylthiazole derivatives I (R = 3-CH3C6H4, 4-BrC6H4, 2-furyl, cyclohexyl, CH3OCH2, ClCH2, etc.) were designed and synthesized according to the structural characteriztics of crizotinib. The target compounds I were evaluated for their in vitro antiproliferative activity against A549, HeLa, HT29, and Karpas299 human cancer cell lines. Based on results of biol. studies, some of these compounds exhibited significant antiproliferative activity. Compound I (R = 3,4-Cl2C6H3) possessed outstanding growth inhibitory effects on the four cell lines, especially for HT29 cell with IC50 value of 2.01 μM. Along with the biol. assay data, a mol. docking study suggests that the target compounds were a potential inhibitor.

Journal of Chemistrypublished new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Application of C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhang, Xiaolin; Yang, Hongxia Ou; Ding, Yonghong published the artcile< The synthesis and characterization of potential novel active compounds, 2-aminothiazole derives Schiff bases>, Electric Literature of 57493-24-0, the main research area is aromatic ketone thiourea cyclocondensation; aminothiazole preparation condensation aryl aldehyde; Schiff base preparation.

Some 4-substituted-2-aminothiazoles were prepared starting from aromatic ketones and thiourea in the presence of powered iodine. Then treating 4-substituted-2-aminothiazole with substituted benzaldehyde gave corresponding 2-aminothiazole derivatives Schiff bases in good yield.

Advanced Materials Research (Durnten-Zurich, Switzerland)published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroaryl). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Electric Literature of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Vo, Duc Duy; Tran, Thi Phuong Anh; Staedel, Cathy; Benhida, Rachid; Darfeuille, Fabien; Di Giorgio, Audrey; Duca, Maria published the artcile< Oncogenic MicroRNAs Biogenesis as a Drug Target: Structure-Activity Relationship Studies on New Aminoglycoside Conjugates>, Category: thiazole, the main research area is MicroRNA structure aminoglycoside antitumor neoplasm; RNA structures; biogenesis; cancer; inhibitors; microRNA.

MicroRNAs (miRNAs) are a recently discovered category of small RNA mols. that regulate gene expression at the posttranscriptional level. Accumulating evidence indicates that miRNAs are aberrantly expressed in a variety of human cancers and that the inhibition of these oncogenic miRNAs could find application in the therapy of different types of cancer. Herein, the authors describe the synthesis and biol. evaluation of new small-mol. drugs that target oncogenic miRNAs production In particular, the authors chose to target two miRNAs (i.e., miRNA-372 and -373) implicated in various types of cancer, such as gastric cancer. Their precursors (premiRNAs) are overexpressed in cancer cells and lead to mature miRNAs after cleavage of their stem-loop structure by the enzyme Dicer in the cytoplasm. Some of the newly synthesized conjugates can inhibit Dicer processing of the targeted premiRNAs in vitro with increased efficacy relative to the previous results (D.D. Vo et al., ACS Chem. Biol. 2014, 9, 711-721) and, more importantly, to inhibit proliferations of adenocarcinoma gastric cancer (AGS) cells overexpressing these miRNAs, thus representing promising leads for future drug development.

Chemistry – A European Journalpublished new progress about Aminoglycosides Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Mishra, Deepak; Fatima, Atiya; Rout, Chittaranjan; Singh, Ram published the artcile< An efficient one-pot synthesis of 2-aminothiazole derivatives>, COA of Formula: C9H7N3O2S, the main research area is aminothiazole preparation; haloketone thioamide cyclization.

A highly efficient, rapid and catalyst free protocol has been developed for the synthesis of 2-aminothiazoles I (R = Br, NO2, OCH3, etc.; R1 = Cl, CN, OCH3, etc.) in THF. Reaction was carried out at room temperature and the products were obtained in high yields without further purification

Chemica Sinicapublished new progress about Cyclization. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, COA of Formula: C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lyashchuk, S. N.; Enya, V. I.; Doroshenko, T. F.; Skrypnik, Yu. G. published the artcile< Study of reaction routes in sulfonation of 2-aminothiazoles with chlorosulfonic acid>, Electric Literature of 57493-24-0, the main research area is thiazole amine sulfonation thermal isomerization thiazolesulfonic thiazolesulfamic acid preparation; charge distribution thiazole amine AM1 calculation sulfonation mechanism.

The sulfonation of 4-substituted 2-aminothiazoles with chlorosulfonic acid under mild conditions afforded primarily C-sulfonation product, 2-amino-5-thiazolesulfonic acids, which undergo thermal isomerization by heating in sulfuric acid into the corresponding stable 2-thiazolesulfamic acids. Reaction of 4-R-thiazole-2-amines (9-12) with ClSO3H gave 2-amino-4-R-thiazole-5-sulfonic acids (1-4; R = Me, 4-BrC6H4, 3-O2NC6H4, 4-ClC6H4); heating of 1-4 at 110° in concentrate H2SO4 gave 4-R-thiazole-2-sulfamic acids (5-8). Quantum chem. calculations at AM1 level revealed the presence of considerable neg. charge on the C-5 atom of the thiazole ring of 9-12, which accounts for the opposite sulfonation patterns for the aminothiazoles and aniline.

Russian Journal of Organic Chemistrypublished new progress about AM1 (molecular orbital method). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Electric Literature of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica