With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57626-37-6,Ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
To the stirred solution of ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate (2a) (5.20 g) in ethanol (40 mL) was added 35%aqueous solution of N2H4H2O (40 mL) and refluxed for 3 h. Thereaction mixture was concentrated to half volume and cooled onice bath, the solids formed were filtered and dried in vacuum ovento get 6-methylimidazo[2,1-b]thiazole-5-carbohydrazide (3a)(4.30 g, 89%) as an Off-white solid. ESI-MS showed 197 [M+H]+.
The synthetic route of 57626-37-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Samala, Ganesh; Devi, Parthiban Brindha; Saxena, Shalini; Meda, Nikhila; Yogeeswari, Perumal; Sriram, Dharmarajan; Bioorganic and Medicinal Chemistry; vol. 24; 6; (2016); p. 1298 – 1307;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica