Category: 57677-79-9

In an article, published in an article, once mentioned the application of 57677-79-9, Name is Ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate,molecular formula is C13H13NO3S, is a conventional compound. this article was the specific content is as follows.Safety of Ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate

To find novel butyrylcholinesterase inhibitors, three novel 2-phenylthiazole derivatives were synthesised. The synthesised compounds were characterised by NMR and single-crystal X-ray diffraction analysis. Hirshfeld surface analysis and two-dimensional fingerprint plots of the compounds were used as a theoretical approach to assess the driving force for crystal structure formation via the intermolecular interactions in the crystal lattices of the synthesised compounds. Among the three compounds, N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro- 1H-pyrazol-4-yl)-2-(4-methoxyphenyl)thiazole-4-carboxamide showed the best butyrylcholinesterase-inhibition activity with an IC50 value of 75.12 muM. A docking study demonstrated that this compound interacts with the peripheral anionic site of butyrylcholinesterase.

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Reference：
Thiazole | C3H7810NS – PubChem,
Thiazole | chemical compound | Britannica

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2-Aryl-4-(ethoxycarbonyl)oxazolidines and thiazolidines (1) were prepared from the corresponding alpha-amino acid ethyl esters containing either hydroxyl or mercapto groups in the beta position by fusion with some aromatic aldehydes.Dehydrogenation of 1 with N-bromosuccinimide gave the corresponding oxazoles and thiazoles.The oxazolidines and thiazolidines gave Mannich bases on interaction with p-nitrobenzaldehyde and piperidine.Acetylation of 1 gave the corresponding N-acetylderivatives, which on fusion in the presence of anhydrous ZnCl2 undergo cyclization, giving the corresponding bicyclic compounds, 5,6,7,8-tetrahydro-1H,3H-pyrrolo<1,2-c>oxazole (or thiazole)-1,3-diones.

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Reference：
Thiazole | C3H7818NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 57677-79-9, Name is Ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate,molecular formula is C13H13NO3S, is a conventional compound. this article was the specific content is as follows.Recommanded Product: 57677-79-9

To find novel butyrylcholinesterase inhibitors, three novel 2-phenylthiazole derivatives were synthesised. The synthesised compounds were characterised by NMR and single-crystal X-ray diffraction analysis. Hirshfeld surface analysis and two-dimensional fingerprint plots of the compounds were used as a theoretical approach to assess the driving force for crystal structure formation via the intermolecular interactions in the crystal lattices of the synthesised compounds. Among the three compounds, N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro- 1H-pyrazol-4-yl)-2-(4-methoxyphenyl)thiazole-4-carboxamide showed the best butyrylcholinesterase-inhibition activity with an IC50 value of 75.12 muM. A docking study demonstrated that this compound interacts with the peripheral anionic site of butyrylcholinesterase.

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Reference：
Thiazole | C3H7810NS – PubChem,
Thiazole | chemical compound | Britannica

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A facile and environment-benign oxidation by molecular oxygen was applied for the conversion of 4-carboxylate thiazolines to 4-carboxylate thiazoles. The substituent effect on thiazoline ring was investigated. It was found that electron-poor group on the thiazoline ring could facilitate the oxidation.

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Reference：
Thiazole | C3H7817NS – PubChem,
Thiazole | chemical compound | Britannica

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I2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles

The efficient synthesis of 2-substituted thiazoles and benzothiazoles has been accomplished employing readily available cysteine esters and 2-aminobenzenethiols as N and S sources. The reaction proceeds under an I2/TBHP system and involves a one-pot tandem cyclization and oxidation sequence. A diverse range of aldehydes is amenable for this transition-metal-free protocol, which provides an alternative method to rapidly access thiazole-containing molecules.

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Reference：
Thiazole | C3H7812NS – PubChem,
Thiazole | chemical compound | Britannica