Category: 59020-44-9

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 59020-44-9, Name is 4-Phenylthiazole-2-carboxylic acid, molecular formula is C10H7NO2S. In a Patent，once mentioned of 59020-44-9, HPLC of Formula: C10H7NO2S

The present invention relates to radiolabelled PDE10A ligands which are useful for imaging and quantifying the PDE10A enzyme using positron emission tomography (PET).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.HPLC of Formula: C10H7NO2S. In my other articles, you can also check out more blogs about 59020-44-9

Reference：
Thiazole | C3H5925NS – PubChem,
Thiazole | chemical compound | Britannica

59020-44-9, 4-Phenylthiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,59020-44-9

The desired carboxylic acid (1.2-1.5 eq) is suspended in CH2Cl2, and treated with oxalyl chloride (6 eq) and DMF (catalytic) for 1.5 to 18 hours to obtain a clear solution. The solution was concentrated to dryness and a pyridine suspension of the desired aniline (1.0 eq) was added and the reaction mixture was stirred at room temperature for up to 18 hours or microwave heated (160 deg C, 10 min). If the product precipitates from solution it is collected by filtration, co-evaporated with methanol and purified by chromatography. If it does not precipitate from solution it can be concentrated to dryness, triturated and then purified by chromatography.Acid chlorides were also prepared by suspending the appropriate acid in SOCl2 and heating at reflux for several hours. The excess SOCl2 is removed under reduced pressure, and the residue chased with toluene. The resulting acid chloride was dried under vacuum and used without further pur. The title compound was prepared according to amide synthesis general method B, utilizing 2-(6-((4-(2-methoxyethyl)piperazin-l-yl)methyl)thiazolo[5,4- b]pyridin-2-yl)aniline and 4-phenylthiazole-2-carboxylic acid (1.5 eq). Addition of water to the crude reaction did not precipitate the product, therefore it was concentrated, triturated with hot MeCN, MeCN/EtOAc/MeOH mixture, and EtOAC/MeOH sequentially. The resulting pale yellow solid was lyophilized with a MeCN/water/HCl mixture and subsequently purified on prep HPLC. MS Calcd for C30H30N6O2S2: 570.19. Found (M+H)+ m/z = 571

As the paragraph descriping shows that 59020-44-9 is playing an increasingly important role.

Reference£º
Patent; SIRTRIS PHARMACEUTICALS, INC.; OALMANN, Christopher; DISCH, Jeremy, S.; NG, Pui, Yee; PERNI, Robert, B.; WO2010/71853; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica