Category: 6142-15-0

6142-15-0, Name is 2-Amino-4-methylthiazole hydrochloride, molecular formula is C4H7ClN2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 6142-15-0, Recommanded Product: 2-Amino-4-methylthiazole hydrochloride

Methods are disclosed for improving the appearance of skin by topical administration of thiazole derivatives which inhibit the formation of advanced glycation endproducts, break advanced glycation endproduct-associated crosslinks, and inhibit the function of glucose oxidase. Cosmetic and pharmaceutical compositions comprising the thiazole derivatives are also disclosed.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 2-Amino-4-methylthiazole hydrochloride. In my other articles, you can also check out more blogs about 6142-15-0

Reference：
Thiazole | C3H1970NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 6142-15-0, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 6142-15-0, C4H7ClN2S. A document type is Article, introducing its new discovery.

4-(Methyl- or phenyl)-2-thiazolyl isothiocyanates were synthesized from the appropriate amine hydrochlorides by the thiophosgene method.The <4+2> cycloaddition reaction of 4-methyl-2-thiazolyl isothiocyanate with isocyanates and aldimines afforded thiazolo<3,2-a>-1,3,5-triazine derivatives. 4-Phenyl-2-thiazolyl isothiocyanate on the other hand, did not react with isocyanates.Carbodiimides were found to react with 4-methyl-2-thiazolyl isothiocyanate by a <2+2> cycloaddition to yield the substituted 1,3-thiazetidines.

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Reference：
Thiazole | C3H1975NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.6142-15-0, Name is 2-Amino-4-methylthiazole hydrochloride, molecular formula is C4H7ClN2S. In a Patent，once mentioned of 6142-15-0, Application In Synthesis of 2-Amino-4-methylthiazole hydrochloride

2,3-DIHYDROBENZOFURAN-5-YL COMPOUNDS AS DYRK KINASE INHIBITORS

The present invention relates to compounds of below Formula (I), physiologically functional derivatives or salts thereof, where the groups R1, R2, R3, R4, RA, X1, and A, as well as the variables n, m and p are detailed further herein. In another aspect, the present invention provides methods for their preparation, their medical use and pharmaceutical compositions comprising said compounds, physiologically functional derivatives, solvates or salts thereof.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of 2-Amino-4-methylthiazole hydrochloride, you can also check out more blogs about6142-15-0

Reference：
Thiazole | C3H1968NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article,authors is Ates, Oeznur, once mentioned the application of 6142-15-0, Name is 2-Amino-4-methylthiazole hydrochloride,molecular formula is C4H7ClN2S, is a conventional compound. this article was the specific content is as follows.6142-15-0

4-Carbethoxymethyl-2-[(chloroacetyl/alpha-chloropropionyl/alpha- bromobutyryl/alpha-chloro-(alpha-phenylacetyl)amino]thiazoles (I-IV) were synthesized by reacting 4-carbethoxymethyl-2-aminothiazole with chloroacetyl chloride, alpha-chloropropionyl chloride, alpha-bromobutyryl bromide and alpha-chloro- alpha-phenylacetyl chloride, respectively. Furthermore, I-IV were refluxed with ammonium thiocyanate to give 2-[(4-carbethoxymethylthiazol-2-yl)imino]-4- thiazolidinones (V-VIII). V was refluxed with various aromatic aldehydes to give 5-arylidene-2-[(4-carbethoxymethylthiazol-2-yl)imino]-4-thiazolidinones (IX-XIV). The structures of synthesized compounds were confirmed by elemental analyses, hydrolysis, UV, IR, 1H-NMR and EI mass spectral data. The antimicrobial activities of the compounds were assessed by microbroth dilution technique using Mueller-Hinton broth and Mueller-Hinton Agar. In this study, Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 8739, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 1539, Salmonella typhi, Shigella flexneri, Proteus mirabilis and Candida albicans ATCC 10231 were used as test microorganisms. Among the tested compounds, XI and XIV showed activity against S. aureus (MIC: 78 mug/ml, 1.6 mug/ml), whereas compound V had an activity against S. flexneri (MIC: 39 mug/ml) and compound I against C. albicans (MIC: 125 (mug/ml). Compounds I, IV-XIV were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. Only compounds I and XIV showed 86% and 67% inhibition in the primary screen.

4-Carbethoxymethyl-2-[(chloroacetyl/alpha-chloropropionyl/alpha- bromobutyryl/alpha-chloro-(alpha-phenylacetyl)amino]thiazoles (I-IV) were synthesized by reacting 4-carbethoxymethyl-2-aminothiazole with chloroacetyl chloride, alpha-chloropropionyl chloride, alpha-bromobutyryl bromide and alpha-chloro- alpha-phenylacetyl chloride, respectively. Furthermore, I-IV were refluxed with ammonium thiocyanate to give 2-[(4-carbethoxymethylthiazol-2-yl)imino]-4- thiazolidinones (V-VIII). V was refluxed with various aromatic aldehydes to give 5-arylidene-2-[(4-carbethoxymethylthiazol-2-yl)imino]-4-thiazolidinones (IX-XIV). The structures of synthesized compounds were confirmed by elemental analyses, hydrolysis, UV, IR, 1H-NMR and EI mass spectral data. The antimicrobial activities of the compounds were assessed by microbroth dilution technique using Mueller-Hinton broth and Mueller-Hinton Agar. In this study, Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 8739, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 1539, Salmonella typhi, Shigella flexneri, Proteus mirabilis and Candida albicans ATCC 10231 were used as test microorganisms. Among the tested compounds, XI and XIV showed activity against S. aureus (MIC: 78 mug/ml, 1.6 mug/ml), whereas compound V had an activity against S. flexneri (MIC: 39 mug/ml) and compound I against C. albicans (MIC: 125 (mug/ml). Compounds I, IV-XIV were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. Only compounds I and XIV showed 86% and 67% inhibition in the primary screen.

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Reference£º
Thiazole | C3H1974NS – PubChem,
Thiazole | chemical compound | Britannica