Category: 61830-21-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61830-21-5,Ethyl 2-amino-5-bromothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.,61830-21-5

General procedure: A mixture of 2-amino-5-bromothiazole-4-carboxylate (34, 2.22g,0.01 mol), the appropriate 2-thioxo-quinazoline analogs (14-17,0.01 mol), anhydrous potassium carbonate (1.5 g, 0.01 mol) in DMF(10 ml) was heated under reflux for 14-16 h. Solvent was then removed under reduced pressure and continued as mentioned under compounds 21-24 (Table 1).

The synthetic route of 61830-21-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Al-Omary, Fatmah A.M.; Hassan, Ghada S.; El-Messery, Shahenda M.; Nagi, Mahmoud N.; Habib, El-Sayed E.; El-Subbagh, Hussein I.; European Journal of Medicinal Chemistry; vol. 63; (2013); p. 33 – 45;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

61830-21-5, Ethyl 2-amino-5-bromothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,61830-21-5

General procedure: A mixture of 2-aminothiazole derivatives 2a-h and 3a-e (1.0 mmol) and K2CO3 (4.0 mmol) was stirred at room temperature with drop-wise addition of 4-chlorobutyryl chloride (4.0 mmol) in chloroform for 48 h. The reaction mixture was monitored by TLC (using chloroform/ethyl acetate 9:1). Ammoniated water was added, and the organic layer was separated and dried over anhydrous Na2SO4, and the solvent was removed in vacuum. The resulting precipitate was crystallized from ethanol to give crystals of pure N-(thiazole-2-yl)-4-chlorobutanamide derivatives.

The synthetic route of 61830-21-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ghabbour, Hazem A.; Kadi, Adnan A.; Eltahir, Kamal E. H.; Angawi, Rihab F.; El-Subbagh, Hussein I.; Medicinal Chemistry Research; vol. 24; 8; (2015); p. 3194 – 3211;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica