Electric Literature of 62019-56-1. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 62019-56-1, Name is 2,4-Dichlorothiazole-5-carboxylic acid. In a document type is Article, introducing its new discovery.
Building upon a large, previously reported series of anti-HIV 6-desfluoroquinolones endowed with a peculiar mechanism of action, the inhibition of Tat-mediated transcription, replacement of the quinolone nucleus with a naphthyridone core was shown to be very productive. In this work, the naphthyridone scaffold was investigated in depth by synthesizing various analogues. This led to the identification of NM13 as the most selective derivative obtained in MT-4 cells. It is the result of the successful combination of the 1,6-naphthyridone nucleus and the C7 benzothiazolpiperazine group, which, for the first time, not only grants potent anti-HIV activity but displays very high selectivity. Further studies aimed at a more thorough investigation of the anti-HIV profile of this new derivative are in progress. Best in class: The naphthyridone scaffold was investigated in depth by synthesizing various analogues that were tested for their anti-HIV activity. This led to the identification of a very potent and nontoxic compound, NM13, as the most selective anti-HIV derivative ever obtained in the quinolone class of transcription inhibitors. It is the result of a powerful combination of the 1,6-naphthyridone nucleus and the C7 benzothiazolpiperazine group.
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Reference£º
Thiazole | C3H1525NS – PubChem,
Thiazole | chemical compound | Britannica