Category: 62266-81-3

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 62266-81-3, Name is 6-Chlorobenzo[d]thiazol-2(3H)-one, COA of Formula: C7H4ClNOS.

Carbonyl sulfide (COS), whose molecular structure is similar to CO2 and CS2, could be used as a better alternative carbonyl reagent due to its high chemical activity. However, the unfriendly by-product H2S would be generated when COS is used as a carbonyl reagent in the carbonylation reaction. In this report, the odorless and stable disulfide was used to replace the traditional foul smelling and unstable o-aminobenzenethiol to react with COS for preparing benzothiazolone derivatives in excellent yield, in which coupling reaction of H2S generation and S?S bond cleavage was firstly designed. Notably, the C=O of COS was converted into benzothiazolone derivatives by carbonylation reaction and the sulfur of COS was transformed into sulfur and sulfide after cleaving the S?S bond by a domino reaction of disulfide and COS under mild conditions. This efficient synthetic methodology provided a promising process for the utilization of COS.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.COA of Formula: C7H4ClNOS. In my other articles, you can also check out more blogs about 62266-81-3

Reference£º
Thiazole | C3H6981NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.62266-81-3, Name is 6-Chlorobenzo[d]thiazol-2(3H)-one, molecular formula is C7H4ClNOS. In a Patent，once mentioned of 62266-81-3, Application In Synthesis of 6-Chlorobenzo[d]thiazol-2(3H)-one

Analgesic and antipyretic pharmaceutical compositions containing a benzothiazol-2(3H)-one

Analgesic and antipyretic pharmaceutical dosage unit compositions containing as an active ingredient a compound of the formula STR1 wherein R5 is methyl or methoxy, and R4, R6 and R7 are hydrogen; or R6 is fluorine or chlorine, and R4, R5 and R7 are hydrogen; or R7 is chlorine, and R4, R5 and R6 are hydrogen; or R5 and R6 are methoxy, and R4 and R7 are hydrogen; or R4 is methyl or chlorine, and R5, R6 and R7 are hydrogen; and methods of using said compounds as analgesics and antipyretics.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 62266-81-3 is helpful to your research., Application In Synthesis of 6-Chlorobenzo[d]thiazol-2(3H)-one

Reference：
Thiazole | C3H6982NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 62266-81-3, An article , which mentions 62266-81-3, molecular formula is C7H4ClNOS. The compound – 6-Chlorobenzo[d]thiazol-2(3H)-one played an important role in people’s production and life.

Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists

A novel series of indolyl and dihydroindolyl glycinamides were identified as potent NPY5 antagonists with in vivo activity from screen hit 1. The dihydroindolyl glycinamide 10a significantly inhibits NPY5 agonist induced feeding at a dose of 0.1 mg/kg. The indolyl glycinamide 12c also inhibits NPY5 agonist induced feeding at a dose of 1 mg/kg. Both compounds 10a and 12c represent potential tools for further investigation into the biology of the NPY5 receptor.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 62266-81-3, help many people in the next few years., Reference of 62266-81-3

Reference：
Thiazole | C3H6983NS – PubChem,
Thiazole | chemical compound | Britannica

62266-81-3, 6-Chlorobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,62266-81-3

Reference example 13 6-chloro-3-[2-(dimethylamino)ethyl]-2-benzothiazolone (XIIe) A solution of compound (VIII) (9.28 g, 50 mmol), N,N-dimethylaminoethylchloride hydrochloride (XIe) (7.92 g, 55 mmol), and K2 CO3 (16.58 g, 120 mmol) in acetone (93 ml) was refluxed for 20 hours with stirring. After the reaction was complete, the reaction mixture was concentrated in vacuo. The residue was extracted with ethyl acetate. The layer of ethyl acetate was dried over MgSO4 and subjected to column chromatography on silica gel. From the elude eluted with ethyl acetate, compound (XIIe) (3.3 g, yield=64.3%) was obtained as an oil. IRnumax(nujol)(cm-1):1680,1168. NMR (CDCl3)delta:2.31 (6H, S), 2.59 (2H, t, J=7.2), 4.03 (2H, t, J=7.2), 7.01(1H,d,J=8.6),7.29(1H,d,d,J=8.6,2.2),7.41(1H,d,J=2.2).

As the paragraph descriping shows that 62266-81-3 is playing an increasingly important role.

Reference£º
Patent; Shionogi & Co., Ltd.; US5473066; (1995); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica