Category: 6285-57-0

Name: 6-Nitrobenzo[d]thiazol-2-amine《Synthesis, Characterization and Biological Evaluation of 2-(p-Nitrophenyl)quinazolin-4(3H)-one Derivatives》 was published in 2020. The authors were Giradkar, V. N.;Kabra, U. D.;Diwakar, R. S.;Lohiya, R. T.;Umekar, M. J., and the article was included in《Russian Journal of Organic Chemistry》. The author mentioned the following in the article:

A series of novel 2-(4-nitrophenyl)-3-(R-benzothiazol-2-yl)quinazolin-4(3H)-ones I [R = H, 5-Br, 6-NO₂, etc.] was synthesized from the 2-aminobenzothiazoles and 2-(4-nitrophenyl)-4H-3,1-benzoxazin-4-one via a nucleophilic addition reaction. The synthesized compounds I were tested for anticonvulsant, antimicrobial, and antioxidant activities. All the compounds I increased the seizure latency compared to control. Compound I [R = 6-NO₂] exhibited significant anticonvulsant activity, comparable to that of the standard drug Phenytoin. Antimicrobial activity testing revealed moderate to good activity in all the test compounds, I and I [R = H, 6-NO₂] compared in activity with the standard drug Chloramphenicol. The antioxidant activity of compounds I [R = H], I [R = 5-Br] and I [ R = 4,6-Me₂] IC₅₀ 39.30, 15.55, and 42.95μg/mL, resp. was found to be higher compared to the standard drug ascorbic acid (IC50 48.30μg/mL). To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Name: 6-Nitrobenzo[d]thiazol-2-amine) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Cindric, Maja;Peric, Mihaela;Kralj, Marijeta;Martin-Kleiner, Irena;David-Cordonnier, Marie-Helene;Paljetak, Hana Cipcic;Matijasic, Mario;Verbanac, Donatella;Karminski-Zamola, Grace;Hranjec, Marijana published 《Antibacterial and antiproliferative activity of novel 2-benzimidazolyl- and 2-benzothiazolyl-substituted benzo[b]thieno-2-carboxamides》. The research results were published in《Molecular Diversity》 in 2018.Application In Synthesis of 6-Nitrobenzo[d]thiazol-2-amine The article conveys some information:

Novel (nitro/amino)substituted 2-benzimidazolyl and 2-benzothiazolyl benzo[b]thieno-2-carboxamides I and I • HCl [R¹ = R² = H, NH₂, NO₂; X = NH, S] were designed and synthesized as potential antibacterial agents. The antibacterial activity of these compounds I were evaluated against Gram-pos. (Staphylococcus aureus and Enterococcus faecalis) and Gram-neg. bacteria (Escherichia coli and Moraxella catarrhalis). The most promising antibacterial activity was observed for the nitro- and amino-substituted benzimidazole derivatives I [R¹ = H; R² = NH₂, NO₂; X = NH] and I •Hcl [R¹ = H, R² = NH₂, X = NH; R¹ = NH₂, R² = H, X = NH] with MICs 2-8 μg/mL. Addnl., compounds with inferior antibacterial activity were further tested for their antiproliferative activity in-vitro against three human cancer cell lines. Amino-substituted benzothiazole hydrochloride salt I [R¹ = H, R² = NH₂, X = S] displayed the most pronounced and selective activity against the MCF-7 cell line with an IC₅₀ of 40 nM. Furthermore, DNA binding experiments of selected derivatives indicated that DNA cannot be considered as a primary biol. target for this type of compounds6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) were involved in the experimental procedure.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Application In Synthesis of 6-Nitrobenzo[d]thiazol-2-amine) is an antimicrobial agent that inhibits bacterial growth by cleaving the peptide bonds of proteins. It has been shown to be active against a number of microorganisms, including Gram-positive and Gram-negative bacteria, as well as fungi.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Behera, Ahalya;Rakshit, Amitava;Sahoo, Ashish K.;Patel, Bhisma K. published 《One Pot Sequential Synthesis of N-[2-(Phenylsulfinyl)phenyl]acetamides: A Ring Opening Rearrangement Functionalization (RORF)》 in 2019. The article was appeared in 《European Journal of Organic Chemistry》. They have made some progress in their research.Safety of 6-Nitrobenzo[d]thiazol-2-amine The article mentions the following:

A Cu^II catalyzed one-pot sequential synthesis of N-[2-(phenylthio)phenyl]acetamides from benzo[d]thiazol-2-amines, iodoarenes and carboxylic acids (RCOOH) has been accomplished via ring opening rearrangement functionalization (RORF). Here, the ring opening is associated with the loss of carbon and nitrogen atoms with concurrent S-arylation and N-acylation leading to ortho-bifunctionalized products. A further sequential addition of tert-Bu hydroperoxide (TBHP) results in the formation of a sulfur oxidized product, N-[2-(phenylsulfinyl)phenyl]acetamide. A plausible mechanism has been proposed for this unprecedented ring opening rearrangement functionalization (RORF).6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) were involved in the experimental procedure.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Safety of 6-Nitrobenzo[d]thiazol-2-amine) inhibits the activity of amines, which are small molecules found in many pharmaceuticals. The chemical structure of this drug contains one or more methylene groups that can be activated by diazonium salt to form an intermediate molecule with a reactive amine group.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Jana, Asim;Bhaumick, Prabhas;Panday, Anoop Kumar;Mishra, Richa;Choudhury, Lokman H. published 《I₂/DMSO mediated multicomponent reaction for the synthesis of 2-arylbenzo[d]imidazo[2,1-b]thiazole derivatives》 in 2019. The article was appeared in 《Organic & Biomolecular Chemistry》. They have made some progress in their research.HPLC of Formula: 6285-57-0 The article mentions the following:

Synthesis of a series of 2-arylbenzo[d]imidazo[2,1-b]thiazoles tethered with barbituric acid moiety was reported from the three component reaction of 2-aminobenzothiazoles, barbituric acids and terminal aryl acetylenes or aryl Me ketones in the presence of I₂ in DMSO medium. Both conventional and microwave heating conditions was used for this multicomponent reaction. The salient features of this methodol. are: (i) formation of one C-C and two C-N bonds in one-pot under metal-free oxidation followed by cyclization (ii) selective formation of the fused imidazole ring, (iii) wide substrate scope (iv) easy purification of the products (v) products having more than one pharmaceutically important motifs and (vi) gram scale synthesis possible.6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) were involved in the experimental procedure.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0) has been used:
as model analyte for voltammetric determination of electrochemically reducible organic substances;
in the synthesis of 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide derivatives;
in the preparation of push-pull nonlinear optical chromophores containing thiazole and benzothiazole acceptors;
as a base in dye production by diazotation reaction.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Alom, Nur-E.;Kaur, Navdeep;Wu, Fan;Saluga, Shannon Jasmine;Li, Wei published 《Catalytic Regio- and Stereoselective Alkene Sulfenoamination for 1,4-Benzothiazine Synthesis》 in 2019. The article was appeared in 《Chemistry – A European Journal》. They have made some progress in their research.Synthetic Route of C7H5N3O2S The article mentions the following:

An alkene sulfenoamination reaction with 2-aminothiophenol was developed using iodide catalysis. This reaction rendered access to useful 1,4-benzothiazines such as I [R¹ = H, Ph, 1-naphthyl, etc.; R² = H, Me, Ph; R³ = H, Me, n-Pr, n-hexyl, (CH₂)₂Ph] with good functional group compatibility including both electron-donating and electron-withdrawing substituents. The reaction was proposed to proceeded through an inversion of the polarity of the thiol functionality. Our mechanistic studies revealed that both thiiranium and thiyl radical pathways were plausible and that the disulfide reagent could also function as a viable substrate in this reaction. To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Synthetic Route of C7H5N3O2S) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of C7H5N3O2SIn 2018, Ahlawat, Aarti;Khatkar, Priyanka;Singh, Vikramjeet;Asija, Sonika published 《Diorganotin(IV) complexes of Schiff bases derived from salicylaldehyde and 2-amino-6-substituted benzothiazoles: synthesis, spectral studies, in vitro antimicrobial evaluation and QSAR studies》. 《Research on Chemical Intermediates》published the findings. The article contains the following contents:

In the present work, Schiff base ligands (1–4) were prepared by condensation of 2-amino-6-substituted-benzothiazole and salicylaldehyde in a 1:1 molar ratio and were further treated with diorganotindichloride R’₂SnCl₂ leading to a series of organotin(IV) complexes (5–20) of type R’₂SnL^1-4Cl [R’ = Ph, Bu, Et, Me]. The prepared Schiff base ligands and the organotin(IV) complexes were characterized by various spectroscopic techniques (¹H, ¹³C, ¹¹⁹Sn NMR, FT-IR) and phys. techniques. All the synthesized compounds were evaluated for in vitro antibacterial and antifungal activity against two Gram pos. bacterial strains B. cereus, S. aureus, two Gram neg. bacterial strains E. coli, P. aeruginosa and two fungal strains A. niger and A. flavus by serial dilution method. The spectral data revealed that the complexes were pentacoordinated with bidentate ligands coordinated through oxygen and nitrogen. The results of antimicrobial activity revealed that the synthesized complexes were more toxic towards Gram pos. bacterial strains as compared to Gram neg. bacterial strains. From the results of QSAR anal., it was indicated that the antimicrobial activity of the synthesized compounds were controlled by topol. parameters (mol. connectivity indexes). To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Electric Literature of C7H5N3O2S) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zheng, Jun;Woerl, Benjamin;Breit, Bernhard published 《Rhodium-Catalyzed Chemo-, Regio-, and Enantioselective Allylation of 2-Aminothiazoles with Terminal Allenes》 in 2019. The article was appeared in 《European Journal of Organic Chemistry》. They have made some progress in their research.Electric Literature of C7H5N3O2S The article mentions the following:

A rhodium-catalyzed chemo-, regio- and enantioselective intermol. coupling reaction of 2-aminobenzothiazoles with terminal allenes is reported. The new reaction displays a wide substrate scope for both reaction partners to deliver the allylation products in good yields, with excellent regio- and enantioselectivity. This novel methodol. was further applied in an efficient synthesis of chiral isothiourea. And 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) was used in the research process.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0) has been used:
as model analyte for voltammetric determination of electrochemically reducible organic substances;in the synthesis of 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide derivatives;in the preparation of push-pull nonlinear optical chromophores containing thiazole and benzothiazole acceptors;as a base in dye production by diazotation reaction.
in the synthesis of 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide derivatives;
in the preparation of push-pull nonlinear optical chromophores containing thiazole and benzothiazole acceptors;
as a base in dye production by diazotation reaction.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Product Details of 6285-57-0《Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents》 was published in 2018. The authors were Altintop, Mehlika D.;Sever, Belgin;Ozdemir, Ahmet;Ilgin, Sinem;Atli, Ozlem;Turan-Zitouni, Gulhan;Kaplancikli, Zafer A., and the article was included in《Anti-Cancer Agents in Medicinal Chemistry》. The author mentioned the following in the article:

In an attempt to develop potent antitumor agents, the synthesis of a series of N-(6-substituted benzothiazol-2-yl)-2-[(5-(arylamino)-1,3,4-thiadiazol-2-yl)thio]acetamides (1-14) was described and their cytotoxic effects on A549 human lung adenocarcinoma, MCF-7 human breast adenocarcinoma, HepG2 human hepatocellular carcinoma and NIH/3T3 mouse embryonic fibroblast cell lines were investigated using MTT assay. Phenyl-substituted compounds (8-14) were found to be more effective than naphthyl-substituted compounds (1-7) on cancer cells. Compounds 8, 9, 10, 12, 13 and 14 were identified as the most potent anticancer agents on MCF-7 and HepG2 cell lines and therefore their effects on DNA synthesis and apoptosis/necrosis in MCF-7 cell line were evaluated. Among these compounds, N-(6-methoxybenzothiazol-2-yl)-2-[(5- (phenylamino)-1,3,4-thiadiazol-2-yl)thio]acetamide (13) was the most selective anticancer agent against MCF-7 and HepG2 cell lines with a SI value of 100. On the other hand, compounds 8, 9, 10, 12, 13 and 14 inhibited DNA synthesis in MCF-7 cell line in a dose-dependent manner. Flow cytometric analyses clearly indicated that the compounds showed significant anticancer activity against MCF-7 cell line via the induction of apoptosis dose dependently. According to in vitro assays, compounds 8, 9, 10, 12, 13 and 14 stand out as promising candidates for further studies. To complete the study, the researchers used 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) .

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0Product Details of 6285-57-0) has been shown to lower blood pressure in mice by inhibiting angiotensin converting enzyme and potassium channels. This drug also has a protective effect on the heart and brain from ischemia reperfusion injury.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nishad, Ravi K.;Shukla, Karuna S.;Chawla, Pooja A. published 《Design and Synthesis of 2-Substituted Benzothiazole Derivatives as Antioxidant and Antimicrobial Agents》 in 2020. The article was appeared in 《Current Bioactive Compounds》. They have made some progress in their research.Recommanded Product: 6-Nitrobenzo[d]thiazol-2-amine The article mentions the following:

An upsurge in the number of antibiotic-resistant microbial infections has warranted the discovery and development of new antibiotics. This is a matter of great concern for effective therapy for a search of novel antimicrobial agents. Literature has a number of reports of involvement of oxidative stress due to an imbalance between the generation and neutralization of free radicals in many diseases. Heterocyclic compounds have been involved in the treatment of various disorders. Benzothiazole is one such heterocyclic nucleus having benzene ring merged with the thiazole ring. Among the various substitutions possible in this nucleus, substitutions at position-2 have already been reported with potential bioactivities. Thus, different substituted compounds have been synthesized which could serve as antimicrobials and antioxidants. Benzothiazole derivatives (B₁-B₇) were synthesized by two-step reactions and the structures were confirmed through IR, mass and NMR spectroscopy. The compounds were evaluated for in vitro antioxidant and antimicrobial activities using standard methods. The results of antibacterial and antifungal activity showed that compound B₄ exhibited maximum activity against all the tested strains of microorganisms with the zone of inhibition 17.1-18.5 mm and MIC value 1.1-1.5μg/mL. Compound B₅ exhibited potent antioxidant activity. The compounds substituted with halogen on the aryl ring showed increased antimicrobial activity as seen in the case of compound B₄ (6-fluoro). The compounds substituted with a hydroxyl group (B₅) exhibited good antioxidant activity.6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) were involved in the experimental procedure.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Recommanded Product: 6-Nitrobenzo[d]thiazol-2-amine) is an antimicrobial agent that inhibits bacterial growth by cleaving the peptide bonds of proteins. It has been shown to be active against a number of microorganisms, including Gram-positive and Gram-negative bacteria, as well as fungi.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Jakopec, Silvio;Pantalon Juraj, Natalija;Brozovic, Anamaria;Jadresko, Dijana;Peric, Berislav;Kirin, Srecko I.;Raic-Malic, Silvana published 《Ferrocene conjugates linked by 1,2,3-triazole and their Zn(II) and Cu(II) complexes: Synthesis, characterization and biological activity》. The research results were published in《Applied Organometallic Chemistry》 in 2022.Synthetic Route of C7H5N3O2S The article conveys some information:

Ferrocene derivatives with mono- Py₂NCH₂Trz-1-R (8a–c; Py = 2-pyridyl, Trz = 1,2,3-triazol-5-yl; R = Fc, FcCH₂, FcCHMe) and bis-1,2,3-triazolyl fc(CH₂-1-TrzCH₂NPy₂)₂(9, fc = 1,1′-ferrocenediyl) and ArN(CH₂Trz-1-R)₂ (10a–13c; R = Fc, FcCH₂, FcCHMe; Ar = Ph, 2-benzothiazolyl, 6-chloro-2-benzothiazolyl, 6-nitro-2-benzothiazolyl) chelating groups were synthesized by regioselective copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes with ferrocene azides. Metal complexes of the ligands were prepared with Cu(II) and Zn(II) salts. Crystal structures of ligands 9 and 11a were determined, as well as the structures of complexes [Cu(8a)₂](CF₃SO₃)₂ (8a-Cu) and [Cu(8c)₂(MeOH)₂](BF₄)₂ (8c-Cu). In addition to NMR and UV-Vis spectroscopy, the metal complexes were characterized by cyclic voltammetry. The cytotoxic effect of ferrocene conjugates and their Zn(II) and Cu(II) complexes was explored, and cell cycle anal. was performed. The complex [Cu(8c)₂](CF₃SO₃)₂ showed the most prominent and selective cytotoxicity on cervical carcinoma (HeLa), ovarian cancer (MES-OV), non-small cell lung cancer (A549) and breast carcinoma (MDA-MB-231) cells. This complex increased cell population in the S and G₂/M phase of the cell cycle, which was accompanied by an increase of the cells present in the sub-G₀/G₁ fraction. And 6-Nitrobenzo[d]thiazol-2-amine (cas: 6285-57-0) was used in the research process.

6-Nitrobenzo[d]thiazol-2-amine(cas:6285-57-0 Synthetic Route of C7H5N3O2S) inhibits the activity of amines, which are small molecules found in many pharmaceuticals. The chemical structure of this drug contains one or more methylene groups that can be activated by diazonium salt to form an intermediate molecule with a reactive amine group.

Reference:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica