Category: 64987-16-2

On January 8, 2004, Polisetti, Dharma Rao; Kodra, Janos Tibor; Lau, Jesper; Bloch, Paw; Valcarce-Lopez, Maria Carmen; Blume, Niels; Guzel, Mustafa; Santhosh, Kalpathy Chidambareswaran; Mjalli, Adnan M. M.; Andrews, Robert Carl; Subramanian, Govindan; Ankersen, Michael; Vedso, Per; Murray, Anthony; Jeppesen, Lone published a patent.Reference of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of thiazolyl aryl ureas as activators of glucokinase. And the patent contained the following:

The title compounds [I; A1 = arylene, heteroarylene, fused cycloalkylarylene, etc.; L1 = a bond, O, S, SO, etc.; G1 = alkyl, cycloalkyl, cycloalkylalkylene, etc.; L2 = a bond, alkylene, alkenylene, etc.; L3 = CO, COCO, COCH2CO, SO2; R1 = alkyl, alkenyl, alkynyl, etc.; G2 = heteroaryl, fused heterocyclylheteroaryl, cycloalkylheteroaryl, etc.] which are activators of glucokinase and may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial (no data), were prepared and formulated. Thus, reacting 2-phenoxyaniline with 2-aminothiazole and 1,1′-carbonyldiimidazole afforded 95% the urea II. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Reference of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to thiazolyl aryl urea preparation formulation glucokinase activator antidiabetic and other aspects.Reference of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 6, 2019, Quddus, Abdul; Novak, Andrew; Cousin, David; Chatzopoulou, Elli; Blackham, Emma; Jones, Geraint; Thomas, Jennifer; Wrigglesworth, Joseph; Duffy, Lorna; Birch, Louise; George, Pascal; Ahmed, Saleh published a patent.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of substituted sulfonamidothiazoles as CTRS1 inhibitors. And the patent contained the following:

The invention relates to compounds of formula I (wherein R1 is (un)substituted C1-5 alkyl and C0-2 alkyleneC3-5 cycloalkyl; R3 is H, halo, CH3, etc.; R4 and R5 are independently H, halo, C1-6 alkyl, etc.; R6 is H and C1-3 alkyl, etc.; Ar1 is 6-membered aryl and heteroaryl; Ar2 is 6-membered aryl and heteroaryl; R10 is H, halo, C1-3 alkyl, etc.; R11 is H, F, Cl, Me, etc.; R12 is H, halo, C1-4 alkyl, etc.; R13 is H, halo, Me and OMe;) and salts, solvates thereof and derivatives thereof, their preparation and use as CTR synthase 1 inhibitors for the treatment of disorders associated with cell proliferation. Example compound II was prepared by cross-coupling of N-(4-bromophenyl)-2-(2-(cyclopropanesulfonamido)thiazol-4-yl)-2-methylpropanamide with pyrimidin-5-ylboronic acid. The invention compounds were evaluated for their CTRS1 inhibitory activity. From the assay, it was determined that compound II exhibited IC50 value of ≤ 1μM. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to sulfonamidothiazole preparation ctrs1 inhibitor treatment cell proliferation and other aspects.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 11, 2009, Zhang, Xuebo; Yin, Peng; Liu, Gang; Xu, Lichen published a patent.Application of 64987-16-2 The title of the patent was Process for preparation of 2-[2-[[(phenylmethoxy)carbonyl]amino]thiazol-4-yl]acetic acid esters. And the patent contained the following:

The method comprises allowing to react alc. with benzyl chloroformate and base in the presence of 4-dimethylaminopyridine as catalyst at -10-0°C for 1-2 h, heating to 0-15°C, allowing to react for 4-10 h, filtrating, adding 2-(2-amino-thiazol-4-yl)acetic acid ester, further reacting for 12-24 h to obtain 2-[2-[[(phenylmethoxy)carbonyl]amino]thiazol-4-yl]acetic acid ester. The alc. is methanol, ethanol, isopropanol, n-propanol, n-butanol, isobutanol and/or tert-butanol. The base is triethylamine, pyridine and/or sodium carbonate. The inventive method has advantages of short reaction route, low cost, simple operation, less three waste and suitability for industrial production The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application of 64987-16-2

The Article related to phenylmethoxycarbonylamino thiazolyl acetic acid ester preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Application of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 8, 2010, Fang, Weizheng; Zhang, Hongjian; Qian, Dongbo published a patent.COA of Formula: C6H8N2O2S The title of the patent was Method for synthesis of Ceftibuten side chain from 2-aminothiazolylacetic acid. And the patent contained the following:

A process for preparation of Ceftibuten side chain I from 2-aminothiazolylacetic acid via carboxylic group protection, amino protection, hydroxymethylation, Wittig reaction, and mono esterification in five steps (detail procedure given) is disclosed. The process has advantages of no employment of expensive Me 3-methoxyacrylate, lower cost, reduced pollution to environment, simple process, good controllability, high and stable yield, suitability for industrial production The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).COA of Formula: C6H8N2O2S

The Article related to ceftibuten side chain preparation aminothiazolylacetic acid hydroxymethylation wittig esterification, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C6H8N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Campaigne, E.; Selby, T. P. published an article in 1980, the title of the article was Reactions of 4-chloroacetoacetic esters with thioureas.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate And the article contains the following content:

Thiazoles I (R = Me, Et) were prepared in 61 and 83% yields, resp., by cyclizing ClCH2COCH2CO2R (II) with H2NCSNH2. Cyclizing II with III (n = 1, 2) gave 50-88% IV. Hydrolysis of IV (R = Et) gave IV (R = H). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to thiazoleacetate, chloroacetoacetate thiourea cyclization, imidazolethiazole acetate, thiazolopyrimidine acetate, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 27, 1998, Iwasaki, Fumiaki; Miharu, Michiko published a patent.Related Products of 64987-16-2 The title of the patent was Preparation of 2-aminothiazoleacetic acids as intermediates for cephem antibiotics. And the patent contained the following:

Title compounds I (R1 = CO2H-protecting group; R2 = alkyl) are prepared by reaction of thiazoles II (R1 = same as I) with dialkyl carbonates in the presence of aminopyridines. II (R1 = Et) was treated with (t-BuO)2CO in PhMe in the presence of 4-N,N-dimethylaminopyridine at 50° for 7 h to give 77.0% I (R1 = Et, R2 = t-Bu). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Related Products of 64987-16-2

The Article related to aminothiazoleacetic acid preparation cephem antibiotic intermediate, aminothiazole alkoxycarbonylation alkyl carbonate aminopyridine catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 5, 1988, Kinast, Guenther published a patent.Related Products of 64987-16-2 The title of the patent was Preparation of aminothiazole derivatives as cephalosporin antibiotic intermediates. And the patent contained the following:

The title compounds [I; R1 = (substituted) alkyl, cycloalkyl, (hetero)aryl; R2 = CO2R3; R3, R4 = alkyl, alkenyl, cycloalkyl, cycloalkenyl, (hetero)aryl], useful as intermediates for cephalosporin antibiotics, were prepared from iminothiazolineacetates II. A mixture of Et 2-[(tert-butoxycarbonyl)imino]-3-(tert-butoxycarbonyl)-4-thiazoline-4-acetate, BuLi, and AcH in THF was stirred 2 h at -50 to -60° to give Et 2-[2-[(tert-butoxycarbonyl)amino]thiazol-4-yl]-3-[(tert-butoxycarbonyl)oxybutyrate. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Related Products of 64987-16-2

The Article related to thiazole amino preparation antibiotic intermediate, cephalosporin intermediate aminothiazole preparation, antibiotic intermediate aminothiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 12, 2019, Lo, Wen-Ting; Belabed, Hassane; Haucke, Volker; Nazare, Marc; Kuecuekdisli, Murat published a patent.Application of 64987-16-2 The title of the patent was Preparation of fused pyrimidinones as class II phosphoinositide 3-kinase inhibitors useful in treatment of diseases. And the patent contained the following:

The invention relates to preparation of fused pyrimidinones of formula (I) as class II phosphoinositide 3-kinase inhibitors. Compounds I wherein R1, R2, and R3 each independently is N or C; R4 is H, halo, alkoxy, etc.; R5 can be absent (covalent bond to R6), C1-5 alkyl-cycloalkyl; R6 is H, alkyl, aryl, etc.; R7is S, absent (covalent bond to R8), NR, wherein R is H, etc.; R8 cycloalkyl, C1-5 alkyl, etc.; R9 is amide, amine, urea, etc.; R10 is 5-membered heterocyclyl or heteroaryl (except for pyrazolyl, tetrahydrofurfuryl), preferably a 5-membered aromatic heterocycle comprising one or more of N, O and/or S, etc.; n is 0-5, are claimed. The example compound II was prepared by multistep synthesis starting from Me 3-aminopyrazine-2-carboxylate (procedure given). Compounds I were evaluated for PI3K inhibiting activity (data given). Compounds I can be used as medicaments, in particular for the treatment of a medical condition associated with defective PI3K signalling. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application of 64987-16-2

The Article related to fused pyrimidinone preparation pi3k inhibitor disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 7, 2018, Wunderlich, Winfried; Huber, Lukas A.; Leban, Johann Jakob; Pato, Janos; Oerfi, Laszlo; Frigyes, Waczek; Banhegyi, Peter; Sipos, Anna; Szantai-Kis, Csaba published a patent.Category: thiazole The title of the patent was Preparation of 3-amino-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-ones as cyclin dependent kinase inhibitors for the treatment and prophylaxis of cancer. And the patent contained the following:

The invention relates to preparation of pyrazolopyrimidinones of formulas I and II wherein X1 and X4 each independently H, halo, C1-6 alkoxy; X2 is H or halo; X3 is H, COOH, etc., as cyclin dependent kinase (CDK) inhibitors, pharmaceutical compositions comprising the same and the use thereof in particular in the prophylaxis and treatment of cancer and other proliferative diseases. Furthermore the invention relates to processes for the preparation of said 3-amino-pyrazolo[3,4d]pyrimidin-4-ones and intermediates to be used in the processes of the invention. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Category: thiazole

The Article related to pyrazolopyrimidinone preparation cdk inhibitor proliferative disease cancer treatment prophylaxis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 26, 2017, Mai, Xi; Feng, Lihua; Liao, Yijing; Xu, Zhaoxing published a patent.SDS of cas: 64987-16-2 The title of the patent was Purine hydroxamic acid derivative and its preparation method and application in preparing drug for treating histone deacetylases mediated disease. And the patent contained the following:

The title purine hydroxamic acid derivative has structural formula I, wherein R1 is H or Me; R2 is H, halogen, alkyl, alkoxyl, alkylamino, hydroxyl, cyano or nitro. The derivative and its pharmaceutical composition can be used in preparing drug for treating histone deacetylases mediated disease, and has obvious inhibiting effect on histone deacetylases and anti-tumor activity. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).SDS of cas: 64987-16-2

The Article related to purine hydroxamic acid preparation histone deacetylase antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica