Category: 64987-16-2

On June 26, 2012, Bouillot, Anne Marie Jeanne; Laroze, Alain published a patent.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Triazole derivatives as scd inhibitors. And the patent contained the following:

The present invention relates to substituted triazole compounds of the formula (I):and salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for inhibiting SCD activity, such as diseases related to elevated lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome, skin disorders such as acne, diseases or conditions related to cancer and the treatment of symptoms linked to the production of the amyloid plaque-forming Aβ42 peptide such as Alzheimer’s disease and the like. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to triazole preparation stearoyl coa desaturase inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 25, 2007, Feng, Zewang; Sun, Chenghui; Zhao, Xinqi published an article.Name: Methyl 2-(2-aminothiazol-4-yl)acetate The title of the article was Synthesis of 2-(2-benzyloxycarbonylaminothiazol-4-yl)-5-(3-methyl-2-butenyloxycarbonyl) pent-2-enoic acid. And the article contained the following:

2-(2-Benzyloxycarbonylaminothiazol-4-yl)-5-(3-methyl-2-butenyloxycarbonyl) pent-2-enoic acid (1), the key intermediate of ceftibuten, was prepared from Me (2-aminothiazol-4-yl) acetate, which could be easily bought in China through a three-step reaction of amino group protection, Michael addition elimination and selective esterification with an overall yield of 63.0%. This facile and lower-cost process was suitable for industrial production The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Name: Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to benzyloxycarbonylaminothiazol methylbutenyloxycarbonyl pentenoic acid ceftibuten synthesis, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Name: Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 27, 2008, Mitchell, Jeffrey Peter; Lilly, Michael John; Lambert, John Nicholas; Draffan, Alistair George; Bond, Silas; Hufton, Richard; Jahangiri, Saba published a patent.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of substituted arylindazolinone derivative and analogs as viral polymerase inhibitors. And the patent contained the following:

Title compounds I [L = absent or linker; each Y independently = N, NO, or CR4; Z = O, S, or R5; R1 = (un)substituted alkyl, cycloalkyl, aryl, etc.; R2 = (un)substituted cycloalkyl, aryl, or heterocyclyl; R3 = halo, CN, (un)substituted alkyl, etc.; R4 = H, halo, SH, OH, etc.; R5 = H, OH, (un)substituted alkyl, etc.; n = 0 to 4], and their pharmaceutically acceptable salts, are prepared and disclosed as viral polymerase inhibitors. Thus, e.g., II was prepared by amidation of 2-amino-5-bromobenzoic acid with 4-benzyloxyaniline hydrochloride followed by arylation with bromobenzene and cyclization. Select I were evaluated in HCV polymerase inhibition assays (data given). I were disclosed as therapeutic agents for use as viral polymerase inhibitors, in particular inhibitors of viral polymerases within the Flaviviridae family such as hepatitis C virus (HCV). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to indazolinone aryl derivative preparation viral polymerase inhibitor, arylindazolinone analog preparation viral polymerase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 24, 1999, Bierer, Donald E.; Moinet, Gerard G.; Botton, Gerard; Dubenko, Larisa; Patereau, Gerard; Doare, Liliane; Kergoat, Micheline; Mesangeau, Didier; Lu, Qing published a patent.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Piperazine derivatives useful as hypoglycemic agents. And the patent contained the following:

A variety of piperazine derivatives useful as antihyperglycemic agents, pharmaceutical compositions comprising them, and methods for their use are described. For example, compounds I are disclosed [wherein Ar = certain mono- and polycyclic aryl and heteroaryl groups; R1, R2, R3 = H, alkyl, alkoxyalkyl, cycloalkyl, aryl, heteroaryl, arylalkoxy, aryloxy, etc.; or ArNR1 = indolinyl, quinolyl, indolyl, or tetrahydroquinolyl; R4, R5, R6 = H, cycloalkyl, alkyl, alkoxy, halo, CF3, aryl, aryloxy, cyano, CO2H, OH, NH2, NO2, etc.]. The compounds are useful for the treatment of insulin-dependent diabetes mellitus (IDDM or Type I) and non-insulin dependent diabetes mellitus (NIDDM or Type II). For instance, coupling of 4-chloro-2-(chloroacetamido)benzoic acid with 1-(2-methoxyphenyl)piperazine in DMF in the presence of Et3N gave title compound II. Compounds I gave significant reductions of blood glucose in a variety of animal diabetes models. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Safety of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to piperazine preparation hypoglycemic antidiabetic, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 1, 2021, Pan, Zhixiang; He, Haiying; Jiang, Zhigan; Xia, Jianhua; Zhang, Lei; Zhang, Chen; Li, Jian; Chen, Shuhui published a patent.Product Details of 64987-16-2 The title of the patent was Pyrimidine-based compound having inhibitory effect of ketohexokinase (KHK). And the patent contained the following:

Disclosed in the present invention are a compound (e.g., I) having a KHK inhibitory effect or a pharmaceutically acceptable salt thereof, and use thereof in the preparation of drugs for diseases related to abnormal expression of KHK. For instance, the invention compound I was prepared and gave a KHK inhibition IC50 value of 22nM. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Product Details of 64987-16-2

The Article related to pyrimidine heteroaryl preparation ketohexokinase inhibitor nafld nash, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Product Details of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 22, 2004, Shi, Qian; Wang, Hui-kang; Oyama, Masayoshi; Vance, John Robert; Chen, Ming S. published a patent.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of podophyllotoxin derivatives as anticancer compounds. And the patent contained the following:

Podophyllotoxin derivatives, such as I [R1, R2, R3, R7 = H, alkyl; R4, R6 = alkyl; R5 = H, P(O)(ORa)2; Ra = H, alkyl; T = H; XT = :N; X = bond, O, S, NRb; Rb = H, alkyl; Y = 5-membered heteroaryl or heterocyclyl, optionally substituted with one or more halogen, alkyl, cyclyl, aryl, heteroaryl, heterocyclyl, etc.], were prepared for their therapeutic use as anticancer agents. Thus, podophyllotoxin derivative II was prepared via a multistep synthetic sequence starting from 4′-demethyl-4β-bromo-4-desoxypodophyllotoxin (prepared from podophyllotoxin), 2-aminothiazole-4-acetic acid and (trimethylsilyl)diazomethane. II showed unexpectedly high levels of cellular protein-linked DNA breaks (PLDB) induction in KB cells when tested at 5μg/mL. This invention also features a method for treating cancer. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to podophyllotoxin derivative preparation anticancer, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 27, 2003, Boyd, Scott; Caulkett, Peter William Rodney; Hargreaves, Rodney Brian; Bowker, Suzanne Saxon; James, Roger; Johnstone, Craig; Jones, Clifford David; McKerrecher, Darren; Block, Michael Howard published a patent.HPLC of Formula: 64987-16-2 The title of the patent was Preparation of benzamides affecting glucokinase for combined treatment or prevention of type 2 diabetes and obesity. And the patent contained the following:

The invention relates to the use of benzamides (shown as I; variables defined below; e.g. 2-[[3,5-di(2-chlorobenzyloxy)benzoyl]amino]thiazole) or a salt, solvate or prodrug thereof, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK; no data), such as type 2 diabetes, and to the compounds I and methods for preparing them. Twelve pharmaceutical compositions are included. For I: m is 0-2; n is 0-4; and n + m > 0; each R1 = OH, -(CH2)1-4OH, -CH3-aFa, -(CH2)1-44CH3-aFa, -OCH3-aFa, halo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, NH2, -NH-C1-4alkyl, -N-di(C1-4alkyl), CN, formyl, Ph or heterocyclyl optionally substituted by C1-6alkyl. Each R2 is the group Y-X- wherein each X is a linker = -O-Z-, -O-Z-O-Z-, -C(O)O-Z-, -OC(O)-Z-, -S-Z-, -SO-Z-, -SO2-Z-, -N(R6)-Z-, -N(R6)SO2-Z-, -SO2N(R6)-Z-, -(CH2)1-4-, -CH:CH-Z-, -CC-Z-, -N(R6)CO-Z-, -CON(R6)-Z-, -C(O)N(R6)S(O)2-Z-, -S(O)2N(R6)C(O)-Z-, -C(O)-Z-, -Z-, -C(O)-Z-O-Z-, -N(R6)-C(O)-Z-O-Z-, -O-Z-N(R6)-Z-, -O-C(O)-Z-O-Z- or a direct bond; each Z = a direct bond, C2-6alkenylene or -(CH2)p-C(R6a)2-(CH2)q-; each Y = aryl-Z1-, heterocyclyl-Z1-, C3-7cycloalkyl-Z1-, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, -(CH2)1-4CH3-aFa or -CH(OH)CH3-aFa; R3 = Ph or a heterocyclyl; addnl. details are given in the claims. More than 30 example preparations of I are included and >300 specific examples of I are included with characterization data. For example, to prepare 2-[[3,5-di(2-chlorobenzyloxy)benzoyl]amino]thiazole, diisopropylethylamine (2.0 mmol) then 4-dimethylaminopyridine (0.1 mmol) were added to a solution of 2-aminothiazole (1.0 mmol) and 3,5-di(2-chlorobenzyloxy)benzoic acid chloride (1.0 mmol) in CH2Cl2 (10 mL) under Ar at ambient temperature After 80 mins the reaction mixture was filtered, washed with CH2Cl2 and dried under high vacuum to give the title compound as a colorless solid (41%). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).HPLC of Formula: 64987-16-2

The Article related to benzamide preparation glucokinase inhibitor type 2 diabetes obesity, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.HPLC of Formula: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 15, 2001, Corbett, Wendy Lea; Haynes, Nancy-Ellen; Sarabu, Ramakanth published a patent.Formula: C6H8N2O2S The title of the patent was Preparation of substituted phenylacetamides and their use as glucokinase activators. And the patent contained the following:

The title compounds 4-R[(CH2)yX]zC6H4CH(CH2R1)CONHR2 [X = O, SO2; R is a ring; R1 is cycloalkyl; y and z are 0 or 1; R2 is -CONHR3 or a heteroaromatic ring having a ring nitrogen atom adjacent to the connecting ring carbon atom], active as glucokinase activators to increase insulin secretion, were prepared E.g., 2-biphenyl-4-yl-3-cyclopentyl-N-thiazol-2-ylpropionamide was prepared by reaction of 4-biphenylacetic acid with iodomethylcyclopentane, followed by treatment with 2-aminothiazole. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Formula: C6H8N2O2S

The Article related to phenylacetamide preparation glucokinase activator, acetamide phenyl preparation glucokinase activator, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Formula: C6H8N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 27, 1998, Iwasaki, Fumiaki; Miharu, Michiko published a patent.SDS of cas: 64987-16-2 The title of the patent was Preparation of 2-aminothiazoleacetic acids as intermediates for cephem antibiotics.. And the patent contained the following:

Title compounds I (R1 = H; X = two H, O, NOR2; R2 = H, alkyl, OH-protecting group; R3 = NH2-protecting group) are prepared by reaction of heterocycles I (R3 = H; R1 = CO2H-protecting group; X, R2, = same as above) with NH2-protecting agents in organic solvents incompatible with H2O, saponification of thiazoles I (R1 = CO2H-protecting group; R3 = NH2-protecting group; R2, X = same as above) (II) with basic aqueous solution, dissolution of II alkali metal salts in basic aqueous solution, neutralizing them with acids, and isolation. I (R3 = H, X = two H, R1 = Et) was treated with (t-BuO)2CO in PhMe in the presence of 4-N,N-dimethylaminopyridine at 50° for 7 h, saponified with NaOH in H2O at 20° for 1 h, and neutralized with HCl in H2O at ≤20° to give 82.5% I (R1 = H, X = two H, R3 = t-BuO2C). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).SDS of cas: 64987-16-2

The Article related to amino protecting agent condensation thiazoleacetate, thiazoleacetate saponification base aqueous solution, aminothiazoleacetic acid preparation cephem antibiotic intermediate and other aspects.SDS of cas: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 27, 1998, Iwasaki, Fumiaki; Miharu, Michiko published a patent.SDS of cas: 64987-16-2 The title of the patent was Preparation of 2-aminothiazoleacetic acids as intermediates for cephem antibiotics.. And the patent contained the following:

Title compounds I (R1 = H; X = two H, O, NOR2; R2 = H, alkyl, OH-protecting group; R3 = NH2-protecting group) are prepared by reaction of heterocycles I (R3 = H; R1 = CO2H-protecting group; X, R2, = same as above) with NH2-protecting agents in organic solvents incompatible with H2O, saponification of thiazoles I (R1 = CO2H-protecting group; R3 = NH2-protecting group; R2, X = same as above) (II) with basic aqueous solution, dissolution of II alkali metal salts in basic aqueous solution, neutralizing them with acids, and isolation. I (R3 = H, X = two H, R1 = Et) was treated with (t-BuO)2CO in PhMe in the presence of 4-N,N-dimethylaminopyridine at 50° for 7 h, saponified with NaOH in H2O at 20° for 1 h, and neutralized with HCl in H2O at ≤20° to give 82.5% I (R1 = H, X = two H, R3 = t-BuO2C). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).SDS of cas: 64987-16-2

The Article related to amino protecting agent condensation thiazoleacetate, thiazoleacetate saponification base aqueous solution, aminothiazoleacetic acid preparation cephem antibiotic intermediate and other aspects.SDS of cas: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica