Category: 693-95-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.693-95-8,4-Methylthiazole,as a common compound, the synthetic route is as follows.,693-95-8

General procedure: Aniline ligand (10.0mmol) and palladium dichloride (0.886g, 5.0mmol) were dissolved in 15mL of DMAc at room temperature. After the mixture was stirred for 0.5hat 80C, the methanol (50mL) was added and the precipitation was formed. The precipitate of palladium complexes was then dissolved in 5mL dichloromethane, then 20mL hexane was added. After crystallized from the mixture of ethanol and dichloromethylene, the palladium complex was obtained as light yellow crystals.

As the paragraph descriping shows that 693-95-8 is playing an increasingly important role.

Reference£º
Article; He, Xiao-Xi; Li, Yan-Fang; Huang, Ju; Shen, Dong-Sheng; Liu, Feng-Shou; Journal of Organometallic Chemistry; vol. 803; (2016); p. 58 – 66;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.693-95-8,4-Methylthiazole,as a common compound, the synthetic route is as follows.

-Hydroxy-4-(4-methylthiazol-5-yl)benzonitrile Under an atmosphere of nitrogen, a mixture of 4-bromo-2-hydroxybenzonitrile (commercially available from for example Fluorochem) (15 g, 76 mmol), 4-methylthiazole (commercially available from for example Aldri

693-95-8, 693-95-8 4-Methylthiazole 12748, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; YALE UNIVERSITY; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CAMBRIDGE ENTERPRISE LIMITED UNIVERSITY OF CAMBRIDGE; CREWS, Craig, M.; BUCKLEY, Dennis; CIULLI, Alessio; JORGENSEN, William; GAREISS, Peter, C.; MOLLE, Inge, Van; GUSTAFSON, Jeffrey; TAE, Hyun-Seop; MICHEL, Julien; HOYER, Dentin, Wade; ROTH, Anke, G.; HARLING, John, David; SMITH, Ian Edward, David; MIAH, Afjal, Hussain; CAMPOS, Sebastian, Andre; LE, Joelle; WO2013/106646; (2013); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

693-95-8, 4-Methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,693-95-8

Step 1 : 2-(aminomethyl)-5-(4-methyl-l,3-thiazol-5-yl)phenol (BI)[0459] To a stirred solution of 2-hydroxy-4-(4-methyl- l,3-thiazol-5-yl)benzonitrile (BH,15.6 g, 72.14 mmol) in tetrahydrofuran (400 mL) under an atmosphere of nitrogen was added LiAlH4(11 g, 289.86 mmol) in several portions at 10 ¡ãC. The resulting mixture was then heated to reflux for 3 h, LC-MS indicated formation of the desired product. The reaction was then cooled to 0 ¡ãC, quenched by the water (10 mL, added slowly and drop wise), 15percent NaOH (aq.) (30 mL) and water (10 mL). The solids precipitated were removed by filtration, the solution phase was concentrated under reduced pressure followed by high vacuum pump to give BI(yield: 65percent). LC-MS (ES+): m/z 220.85 [MH+], tR= 1.02 min (2.6 minute run).

The synthetic route of 693-95-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARVINAS, INC.; JIN, Meizhong; CREW, Andrew, P.; DONG, Hanqing; WANG, Jing; SIU, Kam; FERRARO, Caterina; CHEN, Xin; QIAN, Yimin; (351 pag.)WO2016/118666; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

693-95-8, 4-Methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,693-95-8

General procedure: Typically, (hetero)aryl bromide (1.0 mmol), thiazole derivatives(2.0 mmol), Pd-PEPPSI complexes (0.01e0.5 mol%), base (2 mmol),acid additive (0.3 mmol), and 3mL of DMAc solvent were addedinto a parallel reactor. After heating at 130 C for 4 h, the resultingmixture was cooled to room temperature. Subsequently, 25mL ofwater and 20 mL of dichloromethane were added into the reactor,and the mixture was stirred for another several minutes, followedby extraction three times with dichloromethane (3 x 5 mL). Theorganic layer was then combined, dried over anhydrous sodiumsulfate, filtered, and evaporated under reduced pressure to give thecrude products. The crude products were then purified by silica-gelcolumn chromatography using petroleum etheredichloromethane(15/1) as the eluent. The obtained pure products were characterizedby 1H NMR and 13C NMR spectroscopy, and the spectra can be foundin the Supporting Information. And the isolated yields of productswere obtained based on the amounts of (hetero)aryl bromides.

As the paragraph descriping shows that 693-95-8 is playing an increasingly important role.

Reference£º
Article; Ma, Bei-Bei; Lan, Xiao-Bing; Shen, Dong-Sheng; Liu, Feng-Shou; Xu, Chang; Journal of Organometallic Chemistry; vol. 897; (2019); p. 13 – 22;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

693-95-8, 4-Methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

693-95-8, tep 2: Synthesis of tert-butyl N-[(lS)-l-[4-(4-methyl-l,3-thiazol-5- yl)phenyl] ethyl] carbamate (P)[0421] To a stirred solution of tert-butyl N-[(lS)-l-(4-bromophenyl)ethyl]carbamate (O,15.0 g, 49.97 mmol) in DMA (100 mL), under an atmosphere of nitrogen, was added 4-methyl- 1,3-thiazole (9.9 g, 99.84 mmol), potassium acetate (9.8 g, 99.86 mmol) and Pd(OAc)2(112.5 mg, 0.50 mmol) at rt. The resulting mixture was then stirred at 120C for 2h. The reaction mixture was then cooled to rt, diluted by water (120mL), and extracted with ethyl acetate (200 mL x 3). The organic layers were combined, dried over anhydrous sodium sulfate and then concentrated under reduced pressure to give a crude residue, which was purified by flash silica gel chromatography (eluent: ethyl acetate/petroleum ether, v: v = 1:5) to give P (yield: 47%) as a white solid. LC-MS (ES+): m/z 319.13 [MH+], tR= 0.97 min (2.0 minute run).

693-95-8 4-Methylthiazole 12748, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ARVINAS, INC.; JIN, Meizhong; CREW, Andrew, P.; DONG, Hanqing; WANG, Jing; SIU, Kam; FERRARO, Caterina; CHEN, Xin; QIAN, Yimin; (351 pag.)WO2016/118666; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica