Category: 6973-51-9

Synthetic Route of 6973-51-9, An article , which mentions 6973-51-9, molecular formula is C7H5N3O2S. The compound – 4-Nitrobenzo[d]thiazol-2-amine played an important role in people’s production and life.

A novel series of substituted diaryl imidazo[2, 1-b]benzothiazole derivatives (8a-y) were synthesized by condensation reaction between 2-amino benzothiazole derivatives (3a-g) and substituted a-bromo-1, 2-(substituted) diaryl-1-ethanones (7a-i). The structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopical data. The compounds (8a-y) were evaluated for their in-vitro cytotoxic activity on murine (B16F10) and human (MCF-7) cancer cells by using MTT assay. From the in vitro studies compounds 8p, 8u and 8y were found most effective with an IC50 range of 0.56-27.50 muM in MCF-7 and 2.57-36.54 muM in B16F10 cells.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 6973-51-9, help many people in the next few years., Synthetic Route of 6973-51-9

Reference：
Thiazole | C3H5885NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6973-51-9, Name is 4-Nitrobenzo[d]thiazol-2-amine, molecular formula is C7H5N3O2S. In a Article，once mentioned of 6973-51-9, Application In Synthesis of 4-Nitrobenzo[d]thiazol-2-amine

In the armamentarium of antifungal agents, appropriately functionalized triazines and their derivatives have received considerable attention in the recent past. In this focus review, we have highlighted the investigations regarding antifungal activities of triazines and their derivatives.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Application In Synthesis of 4-Nitrobenzo[d]thiazol-2-amine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 6973-51-9, in my other articles.

Reference：
Thiazole | C3H5875NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 6973-51-9. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 6973-51-9, Name is 4-Nitrobenzo[d]thiazol-2-amine. In a document type is Article, introducing its new discovery.

Some new trisubstituted purinyl thioureido were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains and antifungal strain using a micro dilution procedure. Synthesized compounds 6a-j prove to be effective with minimum inhibitory concentration (MIC) (mg ml-1), among them 6a, 6d, and 6e showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, 1H-NMR, and elemental analysis. Springer Science+Business Media, LLC 2011.

If you are interested in 6973-51-9, you can contact me at any time and look forward to more communication.Reference of 6973-51-9

Reference：
Thiazole | C3H5872NS – PubChem,
Thiazole | chemical compound | Britannica

6973-51-9, Name is 4-Nitrobenzo[d]thiazol-2-amine, molecular formula is C7H5N3O2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 6973-51-9, SDS of cas: 6973-51-9

The triazole analogs were obtained via. multistep synthesis sequence beginning with ethyl nicotinoate 3 which on treatment with hydrazine hydrate yields nicotinoyl hydrazide 4. Intermolecular cyclisation of 4 with 4-methylbenzoic acid in presence of phosphorous oxy chloride affords 2-(3-pyridyl)-5-(4-methylphenyl)-1,3,4-oxadiazole 5. Condensation of 5 with various substituted 2-hydrazino benzothiazole 2a-j results in 3-(3-pyridyl)-5-(4-methylphenyl)-4-(N-substituted-1,3-benzothiazol-2-amino) -4H-1,2,4-triazole 6a-j analogs. All the compounds have been characterized by elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. In vitro antitubercular activity was carried out against Mycobacterium tuberculosis H37Rv strain using Lowenstein-Jensen medium and antimicrobial activity against various bacteria and fungi using broth microdilution method. Compounds 2e, 6a, 6b, 6c, 6d, 6g, 6h and 6i emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antituberculars. Compound 6j showed better antitubercular activity compared to rifampicin. 3-(3-Pyridyl)-5-(4-methylphenyl) -4-(N-substituted-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 6a-j were synthesized and their antitubercular activity against H37Rv and antimicrobial activities have been tested.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.SDS of cas: 6973-51-9. In my other articles, you can also check out more blogs about 6973-51-9

Reference：
Thiazole | C3H5864NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 6973-51-9, An article , which mentions 6973-51-9, molecular formula is C7H5N3O2S. The compound – 4-Nitrobenzo[d]thiazol-2-amine played an important role in people’s production and life.

Alpha-dystroglycan (alpha-DG), a highly glycosylated receptor for extracellular matrix proteins, plays a critical role in many biological processes. Hypoglycosylation of alpha-DG results in various types of muscular dystrophies and is also highly associated with progression of majority of cancers. Currently, there are no effective treatments for those devastating diseases. Enhancing functional O-mannosyl glycans (FOG) of alpha-DG on the cell surfaces is a potential approach to address this unmet challenge. Based on the hypothesis that the cells can up-regulate FOG of alpha-DG in response to certain chemical stimuli, we developed a cell-based high-throughput screening (HTS) platform for searching chemical enhancers of FOG of alpha-DG from a large chemical library with 364,168 compounds. Sequential validation of the hits from a primary screening campaign and chemical works led to identification of a cluster of compounds that positively modulate FOG of alpha-DG on various cell surfaces including patient-derived myoblasts. These compounds enhance FOG of alpha-DG by almost ten folds, which provide us powerful tools for O-mannosylation studies and potential starting points for the development of drug to treat dystroglycanopathy.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 6973-51-9, help many people in the next few years., Synthetic Route of 6973-51-9

Reference£º
Thiazole | C3H5880NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 6973-51-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 6973-51-9, Name is 4-Nitrobenzo[d]thiazol-2-amine, molecular formula is C7H5N3O2S. In a Article£¬once mentioned of 6973-51-9

A series of compounds namely, 3-chloro-4-(2?,4?-dichlorophenyl) -4-methyl-1-(substituted-1?,3?-benzothiazol-2?-yl) -azetidin-2-ones 4a-j and 2-(2?,4?-dichlorophenyl)-2,5-dimethyl-3- (substituted-1?,3?-benzothiazol-2?-yl)-1,3-thiazolidin-4-ones 5a-j have been prepared by the reaction of schiff base derivatives 3 with chloroacetyl chloride in the presence of triethylamine and thiolactic acid, respectively. The schiff base derivatives 3 have been prepared by the condensation of substituted-2-aminobenzothiazole 1 with 2,4-dichloroacetophenone 2. The reactions have been carried out by microwave and conventional methods. The microwave assisted reactions are carried out in a “QPro-M modified microwave oven” made in Canada. Both the azetidinones and thiazolidinones are pharmacologically active and screened for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Salmonella typhi and antifungal activity against Candida albicans.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 6973-51-9 is helpful to your research., Application of 6973-51-9

Reference£º
Thiazole | C3H5882NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6973-51-9, Name is 4-Nitrobenzo[d]thiazol-2-amine, molecular formula is C7H5N3O2S. In a Article£¬once mentioned of 6973-51-9, Recommanded Product: 6973-51-9

Synthesis of some new 2-(N-Tos- or N-Phtaminoacyl or N-Tos- or N-Pht-dipeptidyl)amino-4-nitro-(or-4-methyl)benzothiazole derivatives has been described (II-XXIX).Some of the synthesized derivatives has been found to possess antimicrobial properties against a number of microorganisms. – Key Words: 2-Amino-4-nitrobenzothiazole; 2-Amino-4-methylbenzothiazole; Tosyl and phthalyl of some amino acids.

Synthesis of some new 2-(N-Tos- or N-Phtaminoacyl or N-Tos- or N-Pht-dipeptidyl)amino-4-nitro-(or-4-methyl)benzothiazole derivatives has been described (II-XXIX).Some of the synthesized derivatives has been found to possess antimicrobial properties against a number of microorganisms. – Key Words: 2-Amino-4-nitrobenzothiazole; 2-Amino-4-methylbenzothiazole; Tosyl and phthalyl of some amino acids.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Recommanded Product: 6973-51-9, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 6973-51-9, in my other articles.

Reference£º
Thiazole | C3H5871NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 6973-51-9, Name is 4-Nitrobenzo[d]thiazol-2-amine, molecular formula is C7H5N3O2S. In a Article£¬once mentioned of 6973-51-9, SDS of cas: 6973-51-9

2-(p-Acetylaminobenzenesulfonylamido)-substituted benzothiazoles were prepared from 2-amino-substituted benzothiazoles and p-acetamidobenzenesulfonyl chloride using a mixture of pyridine and Ac2O, which formed an electrophilic N-acetyl- pyridinium complex facilitating condensation to give the desired products by removal of HCl. 2-[4-(Substituted benzothiazol-2-yl) aminosulfonylanilino]pyridine-3-carboxylic acids (synthesized from 2-chloropyridine-3-carboxylic acid and the corresponding substituted 2-(p-aminobenzenesulfonylamido)benzothiazole in 2-ethoxyethanol using Cu-powder and K2CO3) were then converted to acid chlorides, which on further reaction with piperazine and 4-methoxyphenylpiperazine yielded the corresponding 2-[4-(substituted benzothiazol-2-yl)amino-sulfonyl]anilino-3- (piperazinocarbonyl) pyridine and 2-[4-(substituted benzothiazol-2-yl)amino- sulfonyl]anilino-3-[(4-methoxyphenyl)piperazin-1-yl-carbonyl]pyridine. The structures of the new compounds have been established on the basis of their elemental analyses as well as IR, 1H NMR, and mass-spectral data. All the compounds have been screened for antimicrobial activity and found to possess considerable antibacterial activity.

2-(p-Acetylaminobenzenesulfonylamido)-substituted benzothiazoles were prepared from 2-amino-substituted benzothiazoles and p-acetamidobenzenesulfonyl chloride using a mixture of pyridine and Ac2O, which formed an electrophilic N-acetyl- pyridinium complex facilitating condensation to give the desired products by removal of HCl. 2-[4-(Substituted benzothiazol-2-yl) aminosulfonylanilino]pyridine-3-carboxylic acids (synthesized from 2-chloropyridine-3-carboxylic acid and the corresponding substituted 2-(p-aminobenzenesulfonylamido)benzothiazole in 2-ethoxyethanol using Cu-powder and K2CO3) were then converted to acid chlorides, which on further reaction with piperazine and 4-methoxyphenylpiperazine yielded the corresponding 2-[4-(substituted benzothiazol-2-yl)amino-sulfonyl]anilino-3- (piperazinocarbonyl) pyridine and 2-[4-(substituted benzothiazol-2-yl)amino- sulfonyl]anilino-3-[(4-methoxyphenyl)piperazin-1-yl-carbonyl]pyridine. The structures of the new compounds have been established on the basis of their elemental analyses as well as IR, 1H NMR, and mass-spectral data. All the compounds have been screened for antimicrobial activity and found to possess considerable antibacterial activity.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.SDS of cas: 6973-51-9. In my other articles, you can also check out more blogs about 6973-51-9

Reference£º
Thiazole | C3H5888NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.6973-51-9, Name is 4-Nitrobenzo[d]thiazol-2-amine, molecular formula is C7H5N3O2S. In a Article£¬once mentioned of 6973-51-9, Application In Synthesis of 4-Nitrobenzo[d]thiazol-2-amine

2-Amino substituted benzothiazoles 2a-l and 2-chloropyridine-3-carboxylic acid 3 were used to prepare 2-[N-(substitutedbenzothiazolyl)amino]pyridine-3- carboxylic acids (4a-l) in 2-ethoxy ethanol. Acid chlorides (5a-l) were condensed with 2-hydroxyethyl piperazine (6) and 2,3-dichloropiperazine (7) to prepare amide derivatives 2-[N-(substituted benzothiazolyl)amino]pyridin-3-yl (4-(2-hydroxyethyl)piperazin-1-yl)methanones (8a-l) and 2-[N-(substituted benzothiazolyl) amino]pyridin-3-yl(2,3- dichloropiperazine-1-yl)methanones (9a-l), respectively. The structures of new compounds have been established on the basis of elemental analysis and spectral (IR, 1H NMR, and Mass spectra) studies. The in vitro antimicrobial activity was screened for all the synthesized compounds. Variable and modest activity were observed against the investigated strains of bacteria and fungi. Springer Science+Business Media, LLC 2010.

2-Amino substituted benzothiazoles 2a-l and 2-chloropyridine-3-carboxylic acid 3 were used to prepare 2-[N-(substitutedbenzothiazolyl)amino]pyridine-3- carboxylic acids (4a-l) in 2-ethoxy ethanol. Acid chlorides (5a-l) were condensed with 2-hydroxyethyl piperazine (6) and 2,3-dichloropiperazine (7) to prepare amide derivatives 2-[N-(substituted benzothiazolyl)amino]pyridin-3-yl (4-(2-hydroxyethyl)piperazin-1-yl)methanones (8a-l) and 2-[N-(substituted benzothiazolyl) amino]pyridin-3-yl(2,3- dichloropiperazine-1-yl)methanones (9a-l), respectively. The structures of new compounds have been established on the basis of elemental analysis and spectral (IR, 1H NMR, and Mass spectra) studies. The in vitro antimicrobial activity was screened for all the synthesized compounds. Variable and modest activity were observed against the investigated strains of bacteria and fungi. Springer Science+Business Media, LLC 2010.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 6973-51-9 is helpful to your research., Application In Synthesis of 4-Nitrobenzo[d]thiazol-2-amine

Reference£º
Thiazole | C3H5887NS – PubChem,
Thiazole | chemical compound | Britannica