Category: 70202-00-5

On January 31, 1979, Suzuki, Norio; Tanaka, Yoshiaki; Dohmori, Renzo published an article.Recommanded Product: 70202-00-5 The title of the article was Synthesis of antimicrobial agents. I. Synthesis and antimicrobial activities of thiazoloquinoline derivatives. And the article contained the following:

A series of thiazolo[4,5-g]-, [5,4-g]-, [4,5-h]- and [5,4-h]quinoline carboxylic acids was prepared by two methods. The first was successive condensation of aminobenzothiazole with (EtOCHCH2)(CO2Et), Gould-Jacobs reaction, N-alkylation and hydrolysis; the second was cyclizing aminomercaptoquinolines to give the thiazole. 9-Chloro-8-ethyl-5,8-dihydro-5-oxothiazolo[4,5-g]quinoline-6-carboxylic acid had the highest antimicrobial activity in vitro. The experimental process involved the reaction of 7-chloro-benzothiazol-6-ylamine(cas: 70202-00-5).Recommanded Product: 70202-00-5

The Article related to thiazoloquinoline carboxylate preparation bactericide, condensation aminobenzothiazole methylenemalonate, cyclization methyleneaminothiazoloquinoline, quinoline thiazolo, benzothiazole nitro preparation reduction and other aspects.Recommanded Product: 70202-00-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 4, 1997, Jeon, Yoon T.; Gluchowski, Charles published a patent.SDS of cas: 70202-00-5 The title of the patent was Preparation of novel indoles and benzothiazoles for cloned human alpha 2 receptors. And the patent contained the following:

The title compounds [I-IV; R1-R3 = H, C1-7 alkyl, C2-7 alkenyl, alkynyl; R4-R6 = H, halo, Oh, etc.; R7 = H, NH, C1-7 alkyl, etc.; R8 = H, C1-7 alkyl, C2-7 alkenyl, etc.; R9 = H, Ph, C1-7 alkyl, etc.; X = CH2, O, NH, S] which are selective for cloned human alpha 2 receptors and therefore useful for lowering intraocular pressure, for treating presbyopia, migraine, hypertension, alc. withdrawal, drug addiction, rheumatoid arthritis, ischemic pain, spasticity, diarrhea, nasal congestion, urinary incontinence as well as for use as analgesics, sedatives, anesthetics, cognition enhancers and ocular vasoconstriction agents, were prepared Thus, reaction of 7-bromo-5-aminoindole with 2-imidazoline-2-sulfonic acid (ISA) afforded 46% I [R1-R5 = H; R6 = Br; R7-R9 = H; X = N] which showed pEC50 of 9.36 at alpha 2 receptor. The experimental process involved the reaction of 7-chloro-benzothiazol-6-ylamine(cas: 70202-00-5).SDS of cas: 70202-00-5

The Article related to adrenoceptor agonist indole benzothiazole preparation, anesthetic indole benzothiazole preparation, sedative indole benzothiazole preparation, vasoconstriction ocular indole benzothiazole preparation, antiglaucoma agent indole benzothiazole preparation, migraine indole benzothiazole preparation, antihypertensive indole benzothiazole preparation and other aspects.SDS of cas: 70202-00-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica