Category: 71224-95-8

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 71224-95-8, Name is 2-Aminobenzo[d]thiazole-7-carboxylic acid, category: thiazole.

The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.category: thiazole. In my other articles, you can also check out more blogs about 71224-95-8

Reference£º
Thiazole | C3H2225NS – PubChem,
Thiazole | chemical compound | Britannica

71224-95-8, Name is 2-Aminobenzo[d]thiazole-7-carboxylic acid, molecular formula is C8H6N2O2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 71224-95-8, Recommanded Product: 2-Aminobenzo[d]thiazole-7-carboxylic acid

The invention relates to novel azo dyestuffs of formula (I), the use of such compounds and/or mixtures for printing recording materials, especially paper or papery substrates, textile fibre materials, plastic films and plastic transparencies by the inkjet printing process and also to the recording materials printed thereby.

The invention relates to novel azo dyestuffs of formula (I), the use of such compounds and/or mixtures for printing recording materials, especially paper or papery substrates, textile fibre materials, plastic films and plastic transparencies by the inkjet printing process and also to the recording materials printed thereby.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 2-Aminobenzo[d]thiazole-7-carboxylic acid. In my other articles, you can also check out more blogs about 71224-95-8

Reference£º
Thiazole | C3H2226NS – PubChem,
Thiazole | chemical compound | Britannica

71224-95-8, 2-Aminobenzo[d]thiazole-7-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

71224-95-8, Example 116, 2-amino-N-(5-(2,3-dihvdrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)benzo[d]thiazole-7-carboxamide[00153] HATU (0.201 g, 0.53 mmol) and DIPEA (0.230 mL, 1 .32 mmol) were added to a solution of 2-aminobenzo[d]thiazole-7-carboxylic acid (102 mg, 0.53 mmol) in DMA (3 mL) under an inert atmosphere and the reaction allowed to stir for 15 minutes. Compound 2 (0.125 g, 0.440 mmol) was added and the reaction stirred at ambient temperature for approximately 24 hours and then at 40 C overnight. No product was observed. Additional 2-aminobenzo[d]thiazole-7-carboxylic acid (102 mg, 0.53 mmol) was converted to the acid chloride by treatment with oxalyl chloride (approximately 1 .2 equivalents) and DMF (a few drops) in DCM and the acid chloride added to the reaction mixture. The reaction was diluted with water and the solids filtered. The solids were dissolved in DMF and purified by preparative HPLC. Fractions containing the desired compound were evaporated to dryness to afford the desired material as a white solid (0.043 g, 21 %).1H NMR (400 MHz, DMSO) delta 10.05 (s, 1 H), 10.04 (s, 1 H), 7.87 (d, J = 7.1 Hz, 1 H), 7.82 (d, J = 2.2 Hz, 1 H), 7.62 (dd, J = 2.2, 8.3 Hz, 1 H), 7.49 – 7.56 (m, 3H), 7.47 (s, 2H), 7.39 (t, J = 7.8 Hz, 1 H), 7.25 (d, J = 8.5 Hz, 1 H), 6.98 (d, J = 8.4 Hz, 1 H), 4.28 – 4.35 (m, 4H), 2.21 (s, 3H). m/z (ES+), (M+H)+ = 461 .

The synthetic route of 71224-95-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica