Category: 72054-60-5

Some scientific research about 72054-60-5

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Reference of 72054-60-5, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.72054-60-5, Name is Ethyl 2-amino-5-methylthiazole-4-carboxylate, molecular formula is C7H10N2O2S. In a patent, introducing its new discovery.

A series of thiazole linked indolyl-3-glyoxylamide derivatives were synthesized and evaluated for their in vitro cytotoxic activity against DU145 (prostate), PC-3 (prostate), A549 (lung) and HCT-15 (colon) cancer cell lines by employing the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Among all the synthesized compounds, compound 13d displayed cytotoxicity of IC50 = 93 nM towards DU145 cancer cell line. The most active compound 13d was also tested on RWPE-1 cells and was found to be safe compared to the DU145 cells. The target compounds were also evaluated for their inhibition activity of tubulin polymerization. Further, the treatment of compound 13d on DU145 cells led to the inhibition of cell migration ability. The detailed studies such as acridine orange/ethidium Bromide (AO/EB), DAPI, annexin V-FITC/propidium iodide staining assay suggested that the compound 13d induced apoptosis in DU145 cells. The influence of the cytotoxic compound 13d on the cell cycle distribution was assessed on the DU145 cell line, exhibiting a cell cycle arrest at the G2/M phase. Moreover, the treatment with compound 13d caused collapse of mitochondrial membrane potential and elevated intracellular ROS levels in DU145 cells. The results from molecular modelling studies revealed that these compounds bind at the colchicine binding site of the tubulin. Thus, this new molecular scaffold could be a new lead for the development of anticancer agents that target tubulin.

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Reference£º
Thiazole | C3H7955NS – PubChem,
Thiazole | chemical compound | Britannica

Brief introduction of 72054-60-5

The synthetic route of 72054-60-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72054-60-5,Ethyl 2-amino-5-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.,72054-60-5

General procedure: The solution of acid [11(a-d), 12b] (0.5mmol) and O-(benzotriazol-1-yl)-N,N,N?,N’- tetramethyluronium hexafluorophosphate (0.54mmol) in dry dichloromethane (10mL) and dimethyl aminopyridine (0.1mmol) was added to substituted thiazol-2-amine [2(a-c), 4, or 6] (0.5mmol) at 0C. The reaction mixture was stirred at room temperature for 16-20h. Later the reaction was quenched with water (5.0mL), extracted with dichloromethane (10.0mL¡Á2), and evaporated under reduced pressure. The residue was subjected to silica gel chromatography to give compound [(13a-13o) and (14a-14e)] in good yields

The synthetic route of 72054-60-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Guggilapu, Sravanthi Devi; Guntuku, Lalita; Reddy, T. Srinivasa; Nagarsenkar, Atulya; Sigalapalli, Dilep Kumar; Naidu; Bhargava, Suresh K.; Bathini, Nagendra Babu; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 83 – 95;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica