Category: 72605-86-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72605-86-8,Methyl 2-chlorothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

2-o-tolyl-chroman-6-ol (2.5 g, 10.4 mmol)2-chloro-thiazole-5-carboxylate(1.9 g, 10.6 mmol, 1.02 equiv.) And potassium carbonate (1.9 g, 1.3 equiv.) In dimethylformamide (30 ml) at 50 C for 10 h.The suspension was cooled to room temperature and diluted with water. The aqueous layer was extracted with ethyl acetate and the combined organic layers were washed with water, dried over sodium sulfate, filtered, and the solvent was removed under reduced pressure. The crude product was purified by column chromatography (silica gel; ethyl acetate / heptane gradient). The product was obtained as a pale yellow solid (3.87 g, 98%)., 72605-86-8

72605-86-8 Methyl 2-chlorothiazole-5-carboxylate 12897294, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Sanofi; W ¡¤qiehedisiji; J ¡¤weisidun; N ¡¤lakeerman; M ¡¤bodexiwa; P ¡¤aente; K ¡¤wosi; H ¡¤gegelaiyin; O ¡¤licele; V ¡¤kelafute; P ¡¤beierfuge; G ¡¤makete; (91 pag.)CN102993195; (2017); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

72605-86-8, Methyl 2-chlorothiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

72605-86-8, General procedure: A mixture of compounds 12a-c (6.5 mmol, 1.0 eq), methyl2-chlorothiazole-5-carboxylate (1.2 g, 6.5 mmol, 1.0 eq),and K2CO3 (904.0 mg, 6.5 mmol, 1.0 eq) in CH3CN(10.0 mL) was stirred at 82 C for 16 h. The mixture wasconcentrated to give the crude compounds 13-15, whichwas put into next step without further purification.

As the paragraph descriping shows that 72605-86-8 is playing an increasingly important role.

Reference£º
Article; Zhang, Jiankang; Xi, Jianjun; He, Ruoyu; Zhuang, Rangxiao; Kong, Limin; Fu, Liping; Zhao, Yanmei; Zhang, Chong; Zeng, Linghui; Lu, Jingyi; Tao, Rujia; Liu, Zhengmengtong; Zhu, Huajian; Liu, Shourong; Medicinal Chemistry Research; vol. 28; 10; (2019); p. 1633 – 1647;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica