In 2022,RSC Advances included an article by Moussa, Ziad; Judeh, Zaher M. A.; Alzamly, Ahmed; Ahmed, Saleh A.; Tomah Al-Masri, Harbi; Al-Hindawi, Bassam; Rasool, Faisal; Saada, Sara. Safety of 5-Methoxybenzo[d]thiazole-2-carbonitrile. The article was titled 《Iodine-DMSO mediated conversion of N-arylcyanothioformamides to N-arylcyanoformamides and the unexpected formation of 2-cyanobenzothiazoles》. The information in the text is summarized as follows:
Herein, the effectiveness of the I2-DMSO oxidative system in the preparation of N-arylcyanoformamides RNHC(O)CN (R = Ph, 3-nitrophenyl, 2,4-difluorophenyl, etc.) from N-arylcyanothioformamides RNHC(=S)CN was demonstrated. The synthetic method features mild conditions, broad substrate scope, and high reaction efficiency. Furthermore, this method provides an excellent entry to exclusively afford 2-cyanobenzothiazoles I (R1 = H, OMe; R2 = H, OMe, SMe, benzoxy; R1R2 = -CH=CH-CH=CH-; R3 = H, OMe; R4 = H, I, OMe) which are useful substrates to access new luciferin analogs. The structures of all new products RNHC(O)CN and I were elucidated by multinuclear NMR spectroscopy and high accuracy mass spectral anal. Crystal-structure determination by means of single-crystal X-ray diffraction was carried out on (4-bromophenyl)carbamoyl cyanide, I (R1 = H, R2 = benzoxy, R3 = R4 = H; R1 = H, R2 = R3 = OMe, R4 = H; R1 = OMe, R2 = R3 = H, R4 = OMe; R1 = OMe, R2 = H, R3 = OMe, R4 = I), a key intermediate with mechanistic implications. The experimental part of the paper was very detailed, including the reaction process of 5-Methoxybenzo[d]thiazole-2-carbonitrile(cas: 7267-35-8Safety of 5-Methoxybenzo[d]thiazole-2-carbonitrile)
5-Methoxybenzo[d]thiazole-2-carbonitrile(cas: 7267-35-8) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Safety of 5-Methoxybenzo[d]thiazole-2-carbonitrileTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica