Category: 7336-54-1

New explortion of 7336-54-1

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Safety of N-(5-bromothiazol-2-yl)acetamide. In my other articles, you can also check out more blogs about 7336-54-1

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 7336-54-1, Name is N-(5-bromothiazol-2-yl)acetamide, molecular formula is C5H5BrN2OS. In a Article，once mentioned of 7336-54-1, Safety of N-(5-bromothiazol-2-yl)acetamide

Discovery of selective aminothiazole aurora kinase inhibitors.

Aurora family kinases regulate important events during mitosis including centrosome maturation and separation, mitotic spindle assembly, and chromosome segregation. Misregulation of Aurora kinases due to genetic amplification and protein overexpression results in aneuploidy and may contribute to tumorigenesis. Here we report the discovery of new small molecule aminothiazole inhibitors of Aurora kinases with exceptional kinase selectivity and report a 1.7 A cocrystal structure with the Aurora B:INCENP complex from Xenopus laevis. The compounds recapitulate the hallmarks of Aurora kinase inhibition, including decreased histone H3 serine 10 phosphorylation, failure to complete cytokinesis, and endoreduplication.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Safety of N-(5-bromothiazol-2-yl)acetamide. In my other articles, you can also check out more blogs about 7336-54-1

Reference：
Thiazole | C3H9017NS – PubChem,
Thiazole | chemical compound | Britannica

Simple exploration of 7336-54-1

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 7336-54-1, help many people in the next few years., Application of 7336-54-1

Application of 7336-54-1, An article , which mentions 7336-54-1, molecular formula is C5H5BrN2OS. The compound – N-(5-bromothiazol-2-yl)acetamide played an important role in people’s production and life.

The invention relates to novel compounds corresponding to the general formula (I) below: (I) and also to the method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism),-or alternatively in cosmetic compositions.

The invention relates to novel compounds corresponding to the general formula (I) below: (I) and also to the method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism),-or alternatively in cosmetic compositions.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 7336-54-1, help many people in the next few years., Application of 7336-54-1

Reference£º
Thiazole | C3H9010NS – PubChem,
Thiazole | chemical compound | Britannica

Simple exploration of 7336-54-1

As the paragraph descriping shows that 7336-54-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7336-54-1,N-(5-bromothiazol-2-yl)acetamide,as a common compound, the synthetic route is as follows.,7336-54-1

EXAMPLE 79 A mixture of 2-acetylamino-5-bromothiazole (2.2 g), 4-amino-2-mercaptopyrimidine (1.3 g) and potassium carbonate (2.0 g) in N,N-dimethylformamide (50 ml) was heated at 90 C. for 2 hours with stirring. The reaction mixture was concentrated under reduced pressure and the residue was triturated with water. The precipitation was collected by filtration, washed with water and dried in vacuo to give solid. The solid was subjected to column chromatography on silica gel (silica gel 60, 70-230 mesh; Merck: 200 g) and eluted with a mixture of chloroform and methanol (10:1). The fractions containing the objective compound were combined and concentrated under reduced pressure to give 2-acetylamino-5-(4-aminopyrimidin-2-ylthio)thiazole (1.3 g, yield: 48.7%). mp: 255-258 C. (dec.) IR (Nujol): 3400, 3350, 3200, 1692, 1650, 1585, 1325, 1300 cm-1 NMR (DMSO-d6, 200 MHZ, ppm): 2.16 (3H, s), 6.17 (1H, d, J=6Hz), 7.02 (2H, s), 7.59 (1H, s), 7.85 (1H, d, J=6Hz), 12.31 (1H, s) Mass: M+1 268, M 267, m/e 225, 205, 183

As the paragraph descriping shows that 7336-54-1 is playing an increasingly important role.

Reference£º
Patent; Fujisawa Pharmaceutical Co., Ltd.; US5256675; (1993); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica