Category: 74704-39-5

Pantolactams as androgen receptor antagonists for the topical suppression of sebum production was written by Sexton, Karen E.;Barrett, Stephen;Bridgwood, Katy;Carroll, Matthew;Dettling, Danielle;Du, Daniel;Fakhoury, Stephen;Fedij, Victor;Hu, Lain-Yen;Kostlan, Catherine;Pocalyko, David;Raheja, Neil;Smith, Yvonne;Shanmugasundaram, Veerabahu;Wade, Kimberly. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Category: thiazole The following contents are mentioned in the article:

A series of pantolactam based compounds were identified as potent antagonists for the androgen receptor (AR). Those that possessed properties suitable for topical delivery were evaluated in the validated Hamster Ear Model. Several compounds were found to be efficacious in reducing wax esters, a major component of sebum, initiating further preclin. work on these compounds This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Category: thiazole).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Novel, selective indole-based ECE inhibitors: Lead optimization via solid-phase and classical synthesis was written by Brands, Michael;Ergueden, Jens-Kerim;Hashimoto, Kentaro;Heimbach, Dirk;Schroeder, Christian;Siegel, Stephan;Stasch, Johannes-Peter;Weigand, Stefan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Electric Literature of C5H6BrNS The following contents are mentioned in the article:

A novel class of indole-based endothelin-converting enzyme (ECE) inhibitors was identified by high throughput screening. Systematic optimization of this compound class by means of classical and solid-phase chem. is reported. Optimized compounds with a bisarylamide side chain at the 2-position of the indole skeleton exhibit low-nanomolar activity on ECE. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Electric Literature of C5H6BrNS).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Electric Literature of C5H6BrNS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction was written by Hunt, Fraser;Austin, Caroline;Austin, Rupert;Bonnert, Roger;Cage, Peter;Christie, Jadeen;Christie, Mark;Dixon, Clare;Hill, Steven;Jewell, Robert;Martin, Ian;Robinson, David;Willis, Paul. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Recommanded Product: 74704-39-5 The following contents are mentioned in the article:

As part of a Lead Optimization program to identify small mol. antagonists of the human CXCR2 receptor, a series of substituted thiazolo[4,5-d]pyrimidines was prepared via the application of a novel tandem displacement reaction. E.g., thiazolo[4,5-d]pyrimidine I was prepared from II via a tandem amination. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Recommanded Product: 74704-39-5).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Recommanded Product: 74704-39-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Benzimidazole-4,7-diones as Inhibitors of Protozoal (Toxoplasma gondii) Purine Nucleoside Phosphorylase was written by Alvarez, Frederic;Gherardi, Arnaud;Nebois, Pascal;Sarciron, Marie-Elizabeth;Petavy, Anne-Francoise;Walchshofer, Nadia. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Formula: C5H6BrNS The following contents are mentioned in the article:

Benzimidazole-4,7-diones substituted at the 1- and/or 2-position, e.g., I (R¹ = H, Me), have been synthesized and tested as inhibitors of purine nucleoside phosphorylase isolated from two strains of Toxoplasma gondii (RH and ME 49). They were identified as inhibitors of both enzymes. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Formula: C5H6BrNS).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Formula: C5H6BrNS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Investigation of novel 7,8-disubstituted-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors was written by Hasvold, Lisa A.;Wang, Le;Przytulinska, Magdalena;Xiao, Zhan;Chen, Zehan;Gu, Wen-Zhen;Merta, Philip J.;Xue, John;Kovar, Peter;Zhang, Haiying;Park, Chang;Sowin, Thomas J.;Rosenberg, Saul H.;Lin, Nan-Horng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Reference of 74704-39-5 The following contents are mentioned in the article:

The synthesis and structure-activity relationships (SAR) of Chk1 inhibitors based on a 5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one core are described. Specifically, an exploration of the 7 and 8 positions on this core afforded compounds with improved enzymic and cellular potency. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Reference of 74704-39-5).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Reference of 74704-39-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Studies towards the total synthesis of epothilones: asymmetric synthesis of the key fragments was written by Schinzer, Dieter;Limberg, Anja;Boehm, Oliver M.. And the article was included in Chemistry – A European Journal in 1996.Product Details of 74704-39-5 The following contents are mentioned in the article:

Three key intermediates, the C(1)-C(6) and C(7)-C(12) fragments and a side chain fragment of epothilones A and B were prepared This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Product Details of 74704-39-5).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Product Details of 74704-39-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pseudomonas aeruginosa porphobilinogen synthase assembly state regulators: hit discovery and initial SAR studies was written by Reitz, Allen B.;Ramirez, Ursula D.;Stith, Linda;Du, Yanming;Smith, Garry R.;Jaffe, Eileen K.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2010.Reference of 74704-39-5 The following contents are mentioned in the article:

Porphobilinogen synthase (PBGS) catalyzes the first common step in the biosynthesis of the essential heme, chlorophyll and vitamin B₁₂ heme pigments. PBGS activity is regulated by assembly state, with certain oligomers exhibiting biol. activity and others either partially or completely inactive, affording an innovative means of allosteric drug action. Pseudomonas aeruginosa PBGS is functionally active as an octamer, and inactive as a dimer. We have identified a series of compounds that stabilize the inactive P. aeruginosa dimer by a computational prescreen followed by native PAGE gel mobility shift anal. From those results, we have prepared related thiadiazoles and evaluated their ability to regulate P. aeruginosa PBGS assembly state. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Reference of 74704-39-5).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Reference of 74704-39-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1 was written by Llona-Minguez, Sabin;Hoeglund, Andreas;Jacques, Sylvain A.;Johansson, Lars;Calderon-Montano, Jose Manuel;Claesson, Magnus;Loseva, Olga;Valerie, Nicholas C. K.;Lundbaeck, Thomas;Piedrafita, Javier;Maga, Giovanni;Crespan, Emmanuele;Meijer, Laurent;Burgos Moron, Estefania;Baranczewski, Pawel;Hagbjoerk, Ann-Louise;Svensson, Richard;Wiita, Elisee;Almloef, Ingrid;Visnes, Torkild;Jeppsson, Fredrik;Sigmundsson, Kristmundur;Jensen, Annika Jenmalm;Artursson, Per;Jemth, Ann-Sofie;Stenmark, Paal;Warpman Berglund, Ulrika;Scobie, Martin;Helleday, Thomas. And the article was included in Journal of Medicinal Chemistry in 2016.Quality Control of 4-(Bromomethyl)-2-methylthiazole The following contents are mentioned in the article:

The dCTPase pyrophosphatase 1 (dCTPase) regulates the intracellular nucleotide pool through hydrolytic degradation of canonical and noncanonical nucleotide triphosphates (dNTPs). DCTPase is highly expressed in multiple carcinomas and is associated with cancer cell stemness. Here the authors report on the development of the first potent and selective dCTPase inhibitors that enhance the cytotoxic effect of cytidine analogs in leukemia cells. Boronate I displays a promising in vitro ADME profile, including plasma and mouse microsomal half-lives, aqueous solubility, cell permeability and CYP inhibition, deeming it a suitable compound for in vivo studies. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Quality Control of 4-(Bromomethyl)-2-methylthiazole).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Quality Control of 4-(Bromomethyl)-2-methylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C was written by Storer, R. Ian;Takemoto, Toshiyasu;Jackson, Philip S.;Brown, Dearg S.;Baxendale, Ian R.;Ley, Steven V.. And the article was included in Chemistry – A European Journal in 2004.Recommanded Product: 4-(Bromomethyl)-2-methylthiazole The following contents are mentioned in the article:

The total synthesis of the cytotoxic antitumor natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatog. purification The enantioselective preparation of 3 key fragments heptanone I, (S)-2-methyl-6-heptenal, and thiazole II along with their elaboration via diastereoselective coupling into epothilone C is presented. This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Recommanded Product: 4-(Bromomethyl)-2-methylthiazole).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Recommanded Product: 4-(Bromomethyl)-2-methylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Structure activity studies of the serine-AIB dipeptide domain in 2,3-dihydroisothiazole based growth hormone secretagogues was written by Evers, Britta;Ruehter, Gerd;Berg, Martina;Dodge, Jeffrey A.;Hankotius, Dirk;Hary, Ulrike;Jungheim, Louis N.;Mest, Hans-Juergen;de la Nava, Eva-Maria Martin;Mohr, Michael;Muehl, Brian S.;Petersen, Soenke;Sommer, Birgit;Riedel-Herold, Grit;Tebbe, Mark J.;Thrasher, Kenneth J.;Voelkers, Silke. And the article was included in Bioorganic & Medicinal Chemistry in 2005.Related Products of 74704-39-5 The following contents are mentioned in the article:

A series of growth hormone secretagogues (GHSs) based on 2,3-dihydroisothiazole has been synthesized in the search for a potential treatment of growth hormone deficiency or frailty in the elderly. This paper describes the evaluation of the SAR of the benzyl-D-Ser-aminoisobutyric acid dipeptide fragment. Introduction of substituents in the peptide backbone and in the Ph ring has been investigated, as well as replacements for the benzyl group and for the AIB residue. A number of modifications resulted in enhanced potency over the parent benzyl-D-Ser-AIB derivative This study involved multiple reactions and reactants, such as 4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5Related Products of 74704-39-5).

4-(Bromomethyl)-2-methylthiazole (cas: 74704-39-5) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Related Products of 74704-39-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica