7504-44-1,7504-44-1, 2-(4-Thiazolyl)acetic Acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
HATU (2.12 g, 5.58 mmol) was added to a mixture containing of 2-((lr, 4r)-4-((5 -amino-i -(phenyl sulfonyl)- 1H-pyrrolo[2,3 -b]pyridin-4- yl)amino)cyclohexyl)acetonitrile (Intermediate 2, 1.14 g, 2.78 mmol), 2-(thiazol-4-yl)acetic acid(400 mg, 2.79 mmol), DIPEA (722 mg, 5.59 mmol)and DMF (10 mL) at 0 C (ice / water) and was stirred at room-temperature for 2 hours. The reaction was partitioned between EtOAc (100 mL) and water (100 mL), the aqueous phase was extracted with ethyl acetate (50 mL x 3) and the combined organic extracts were dried over anhydrous Na2504, filtered, and concentrated to dryness. The residue was purified by flash column chromatography to provide the titlecompound (1.5 g, 95% yield) as a yellow solid. MS (ESI): mass calcd. for C26H26N60352,534.65; m/z found, 534.9 [M+H]t
7504-44-1 2-(4-Thiazolyl)acetic Acid 236262, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BACANI, Genesis M.; CHAI, Wenying; KOUDRIAKOVA, Tatiana; KRAWCZUK, Paul J.; KREUTTER, Kevin D.; LEONARD, Kristi; RIZZOLIO, Michele C.; SEIERSTAD, Mark; SMITH, Russel C.; TICHENOR, Mark S.; VENABLE, Jennifer D.; WANG, Aihua; (452 pag.)WO2018/112382; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica