In an article, published in an article, once mentioned the application of 7730-82-7, Name is 2-(Thiazol-5-yl)ethanamine dihydrochloride,molecular formula is C5H10Cl2N2S, is a conventional compound. this article was the specific content is as follows.HPLC of Formula: C5H10Cl2N2S
Histamine exists predominantly as the Ngamma H tautomer of the monocation (IIa) at a physiological pH of 7.4 and structure activity studies indicate that this tautomer is likely to be pharmacologically active species for both H1 and H2 receptors. Effective h2 receptor agonists appear to require a prototropic tautomeric system whereas H1 receptor agonists do not need to be tautomeric. This identifies a chemical difference in the receptor requirements which provides the basis for otaining selective histamine H1 receptor agnosists. Thus 2(2 aminoethyl)thiazole and 2(2 aminoethyl)pyridine are nonautomeric and are highly selective agonists for histamine H1 receptors (H1:H2 ca. 90:1 and 30:1, respectively). In conjunction with the selective H2 receptor agonist, 4 methylhistamine, they are of great value for studying the pharmaclogy of histamine receptors.
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Reference£º
Thiazole | C3H1010NS – PubChem,
Thiazole | chemical compound | Britannica