Category: 777-12-8

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine, molecular formula is C8H5F3N2S. In a Article，once mentioned of 777-12-8, name: 6-(Trifluoromethyl)benzo[d]thiazol-2-amine

Present paper describes the synthesis of some new pyrazole-benzothiazolamine conjugates by molecular conjunction by adopting appropriate synthetic routes. Purification of intermediates and final compounds has been done by recrystallization and chromatographic techniques. Characterization of all the newly synthesized pyrazole-benzothiazolamine derivatives was done by physical and spectral data. The experimental procedure for the preparation of seventeen pyrazole-benzthiazolamine conjugates has been incorporated. Data of synthesized compounds like IR, 1H NMR and Mass spectra were neatly presented. All these compounds were evaluated for their activity against Gram-positive and Gram-negative bacteria and various fungal strains. Anticancer activity has been carried out for the synthesized compounds using HeLa, DU145 and A549 cell lines using MTT assay and we found that the pyrazole-benzothiazolamine conjugates were possess antimicrobial, antifungal and anticancer activities.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 777-12-8 is helpful to your research., name: 6-(Trifluoromethyl)benzo[d]thiazol-2-amine

Reference：
Thiazole | C3H6705NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine,molecular formula is C8H5F3N2S, is a conventional compound. this article was the specific content is as follows.Application In Synthesis of 6-(Trifluoromethyl)benzo[d]thiazol-2-amine

Acylaminobenzothiazole hits were identified as potential inhibitors of Trypanosoma cruzi replication, a parasite responsible for Chagas disease. We selected compound 1 for lead optimization, aiming to improve in parallel its anti-T. cruzi activity (IC50 = 0.63 muM) and its human metabolic stability (human clearance = 9.57 mL/min/g). A total of 39 analogues of 1 were synthesized and tested in vitro. We established a multiparametric structure-activity relationship, allowing optimization of antiparasite activity, physicochemical parameters, and ADME properties. We identified compound 50 as an advanced lead with an improved anti-T. cruzi activity in vitro (IC50 = 0.079 muM) and an enhanced metabolic stability (human clearance = 0.41 mL/min/g) and opportunity for the oral route of administration. After tolerability assessment, 50 demonstrated a promising in vivo efficacy.

Do you like my blog? If you like, you can also browse other articles about this kind. Application In Synthesis of 6-(Trifluoromethyl)benzo[d]thiazol-2-amine. Thanks for taking the time to read the blog about 777-12-8

Reference：
Thiazole | C3H6726NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine, molecular formula is C8H5F3N2S. In a Article，once mentioned of 777-12-8, COA of Formula: C8H5F3N2S

7-Chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines have been synthesized by 2-amino-5-fluoro/5-trifluoromethyl/5-chloro-3-trifluoromethyl benzenethiols condensed with beta-diketone/beta-ketoesters in the presence of DMSO involving oxidative cyclization. Pharmacological activities have also been included.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C8H5F3N2S, you can also check out more blogs about777-12-8

Reference：
Thiazole | C3H6743NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 777-12-8, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine, molecular formula is C8H5F3N2S. In a Article，once mentioned of 777-12-8

In the present work, we designed and synthesized new roflumilast analogues with preferential-selective PDE-4B inhibition activity and improved pharmacokinetic properties. The unsubstituted benzo[d]thiazol-2-yl and -6-yl benzamide derivatives (4a and 6a) showed both good potency and preferential selectivity for PDE-4B. More remarkably, 6c revealed 6 times preferential PDE-4B/4D selectivity with a significant increase of in vitro cAMP and good % inhibition of TNF-alpha concentration. In addition, the in vitro pharmacokinetics of 6c showed good metabolic stability with in vitro CLint (5.67 mL/min/kg) and moderate % plasma protein binding (53.71%). This was reflected onto increased in vivo exposure with a half-life greater than roflumilast by 3 folds (21 h) and a Cmax value of 113.958 ng/mL. Molecular docking attributed its good activity to its key binding interactions in PDE-4B active site with additional hydrogen bonding with amino acids lining the metal pocket. Summing up, 6c can be considered as suitable candidate for further investigation for the treatment of COPD.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 777-12-8 is helpful to your research., Related Products of 777-12-8

Reference：
Thiazole | C3H6712NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine, molecular formula is C8H5F3N2S. In a Article，once mentioned of 777-12-8, COA of Formula: C8H5F3N2S

A mild, general, and high yielding synthesis of N-acyl 2-aminobenzothiazoles has been demonstrated by N-heterocyclic carbene (NHC)-organocatalyzed direct amidation of aldehydes with 2-aminobenzothiazoles proceeding via acyl azolium intermediates. The carbene generated from the triazolium salt under oxidative conditions was the key for the success of this reaction. The method was subsequently applied to the synthesis of various biologically important N-acyl 2-aminobenzothiazoles.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.COA of Formula: C8H5F3N2S. In my other articles, you can also check out more blogs about 777-12-8

Reference：
Thiazole | C3H6739NS – PubChem,
Thiazole | chemical compound | Britannica

777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine, molecular formula is C8H5F3N2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 777-12-8, name: 6-(Trifluoromethyl)benzo[d]thiazol-2-amine

The present invention provides a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of 6-(Trifluoromethyl)benzo[d]thiazol-2-amine. In my other articles, you can also check out more blogs about 777-12-8

Reference：
Thiazole | C3H6686NS – PubChem,
Thiazole | chemical compound | Britannica

777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine, molecular formula is C8H5F3N2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 777-12-8, Computed Properties of C8H5F3N2S

DYRK1A has emerged as a potential target for therapies of Alzheimer’s disease using small molecules. On the basis of the observation of selective DYRK1A inhibition by firefly d-luciferin, we have explored static and dynamic structural properties of fragment sized variants of the benzothiazole scaffold with respect to DYRK1A using X-ray crystallography and NMR techniques. The compounds have excellent ligand efficiencies and show a remarkable diversity of binding modes in dynamic equilibrium. Binding geometries are determined in part by interactions often considered “weak”, including “orthogonal multipolar” types represented by, for example, F-CO, sulfur-aromatic, and halogen-aromatic interactions, together with hydrogen bonds that are modulated by variation of electron withdrawing groups. These studies show how the benzothiazole scaffold is highly promising for the development of therapeutic DYRK1A inhibitors. In addition, the subtleties of the binding interactions, including dynamics, show how full structural studies are required to fully interpret the essential physical determinants of binding.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Computed Properties of C8H5F3N2S. In my other articles, you can also check out more blogs about 777-12-8

Reference：
Thiazole | C3H6717NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine, molecular formula is C8H5F3N2S. In a Article，once mentioned of 777-12-8, Application In Synthesis of 6-(Trifluoromethyl)benzo[d]thiazol-2-amine

A new method has been developed for the synthesis of imidazo[1,2-a]pyridines, imidazo[2,1-b]thiazoles, and benzo[d]imidazo[2,1-b]thiazoles attached to a cycloalkyl or saturated heterocycle containing a tertiary hydroxy substitution. Readily available substituted 2-aminopyridines, 2-aminothiazoles, and 2-aminobenzothiazoles were treated with bromohydroxycycloalkyl ethanones to afford the desired products in good yields.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 777-12-8 is helpful to your research., Application In Synthesis of 6-(Trifluoromethyl)benzo[d]thiazol-2-amine

Reference：
Thiazole | C3H6738NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine, molecular formula is C8H5F3N2S. In a Article，once mentioned of 777-12-8, category: thiazole

A series of amide and urea derivatives of benzothiazole have been synthesized and evaluated for their antiproliferative profile in human SK-Hep-1 (liver), MDA-MB-231 (breast), and NUGC-3 (gastric) cell lines. Among them, compounds 1-2, 16-18, 23, and 25-26 had potent to moderate inhibitory activities. Further these compounds were investigated for their ability to inhibit Raf-1 activity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: thiazole, you can also check out more blogs about777-12-8

Reference：
Thiazole | C3H6731NS – PubChem,
Thiazole | chemical compound | Britannica

777-12-8, Name is 6-(Trifluoromethyl)benzo[d]thiazol-2-amine, molecular formula is C8H5F3N2S, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 777-12-8, COA of Formula: C8H5F3N2S

The invention discloses an organic luminescent material having a force-induced ultra-long room temperature phosphorescence emission characteristic, and a synthesis method and an application thereof. The structure of the organic luminescent material is represented by formula (1) shown in the description; and in the formula (1), R1 is halogen, and R2 is an aryl group or a heteroaryl group. The invention also discloses the synthesis method and the application of the organic luminescent material. The synthesis method of the organic material containing halogenated phthalimide and a trifluoromethylstructure has the advantages of simplicity and easiness in purifying, and the obtained solid material can emit ultra-long room temperature phosphorescence under the action of outside force, that is, the material has the force-induced afterflow characteristics, and the material also has the advantages of good thermal stability, high luminescence efficiency and adjustable luminescence color, and isvery suitable for being applied to the fields of display lighting, pressure sensing, safe-guarding and anti-counterfeiting, and biological imaging.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.COA of Formula: C8H5F3N2S. In my other articles, you can also check out more blogs about 777-12-8

Reference：
Thiazole | C3H6695NS – PubChem,
Thiazole | chemical compound | Britannica