Category: 78364-55-3

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 78364-55-3, C7H6FN3S. A document type is Article, introducing its new discovery., HPLC of Formula: C7H6FN3S

In this study, we report the antimycobacterial and antimicrobial evaluation of newly synthesized 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-substituted-1,3- benzothiazol-2-amino)-4H-1,2,4-triazole 6a-j in good yields. All the synthesized compounds have been established by elemental analysis, IR, 1H NMR, 13C-NMR and Mass spectral data. In-vitro antimycobacterial activity was carried out against (Mycobacterium tuberculosis) H37Rv strain using Lowenstein-Jensen medium and antimicrobial activity against two Gram positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), two Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and three fungal species (Candida albicans, Aspergillus niger, Aspergillus clavatus) using the broth microdilution method. Compounds 2e, 6a, 6g, 6h, and 6j exhibited promising antimicrobial activity whereas compound 6j showed very good antimycobacterial activity. The antimycobacterial and antimicrobial evaluation of newly synthesized 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-substituted-1,3-benzothiazol- 2-amino)-4H-1,2,4-triazoles is reported in detail. Compounds 2e, 6a, 6g, 6h, and 6j exhibited promising antimicrobial activity whereas compound 6j showed very good antimycobacterial activity. Copyright

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Reference：
Thiazole | C3H7038NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 78364-55-3. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 78364-55-3, Name is 6-Fluoro-2-hydrazinylbenzo[d]thiazole. In a document type is Article, introducing its new discovery.

A series of new 1-substituted 3, 5-diarylpyrazolines (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25) were synthesized in good yield by both conventional and microwave-assisted synthesis from alpha, beta- unsaturated ketones (6, 7, 8, 9) in n-butanol and benzothiazole hydrazines (2, 3, 4, 5). All the new compounds were characterized by IR, NMR, and mass spectral data. The synthesized compounds (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25) were evaluated for antibacterial and anthelmintic activities. The compounds showed potent anthelmintic activity against earthworm species (Eudrilus eugeniae) and moderate antibacterial activity against bacterial strains such as Gram positive bacteria, Enterococcus faecalis, Staphylococcus aureus, and Bacillus subtilis, and Gram negative bacteria, Escherichia coli and Proteus mirabilis.

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Reference：
Thiazole | C3H7047NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.78364-55-3, Name is 6-Fluoro-2-hydrazinylbenzo[d]thiazole, molecular formula is C7H6FN3S. In a Article，once mentioned of 78364-55-3, HPLC of Formula: C7H6FN3S

13C NMR spectra of 6-substituted 2-(3′,5′-dimethylpyrazol-1′-yl)benzothiazoles (Ia-d; R: H, OCH3, Cl and F) have been recorded, and complete spectral assignments made on the basis of proton-decoupled, coupled and selectively coupled spectra.

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Reference：
Thiazole | C3H7055NS – PubChem,
Thiazole | chemical compound | Britannica

Related Products of 78364-55-3, An article , which mentions 78364-55-3, molecular formula is C7H6FN3S. The compound – 6-Fluoro-2-hydrazinylbenzo[d]thiazole played an important role in people’s production and life.

1-(6′-Substituted-2′-benzothiazolyl)-3,4-dimethylpyrano<2,3-c>pyrazol-6(1H)-ones (3) have been synthesized (i) by the reaction of 2-hydrazino-6-substituted-benzothiazoles (1) with ethyl acetoacetate and (ii) by the reaction of 1-(6′-substituted-2′-benzothiazolyl)-3-methylpyrazol-5-ols (2) with ethyl acetoacetate.Some of the compounds (3a-c and 3e) display moderate levels of antiinflammatory activity.

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Reference：
Thiazole | C3H7056NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 78364-55-3, Name is 6-Fluoro-2-hydrazinylbenzo[d]thiazole, molecular formula is C7H6FN3S. In a Article，once mentioned of 78364-55-3, Quality Control of: 6-Fluoro-2-hydrazinylbenzo[d]thiazole

A new series of benzothiazole Schiff bases 3-29 was synthesized and screened for antitumor activity against cervical cancer (Hela) and kidney fibroblast cancer (COS-7) cell lines. Results indicated that compounds 3, 14, 19, 27 and 28 have promising activity against Hela cell line with IC50 values of 2.41, 3.06, 6.46, 2.22 and 6.25 mumol/L, respectively, in comparison to doxorubicin as a reference antitumor agent (IC50 2.05 mumol/L). In addition, compound 3 displayed excellent activity against COS-7 cell line with IC50 value of 4.31 mumol/L in comparison to doxorubicin (IC50 3.04 mumol/L). In the present work, structure based pharmacophore mapping, molecular docking, protein-ligand interaction, fingerprints and binding energy calculations were employed in a virtual screening strategy to identify the interaction between the compounds and the active site of the putative target, EGFR tyrosine kinase. Molecular properties, toxicity, drug-likeness, and drug score profiles of compounds 3, 14, 19, 27, 28 and 29 were also assessed.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Quality Control of: 6-Fluoro-2-hydrazinylbenzo[d]thiazole, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 78364-55-3, in my other articles.

Reference：
Thiazole | C3H7053NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.78364-55-3, Name is 6-Fluoro-2-hydrazinylbenzo[d]thiazole, molecular formula is C7H6FN3S. In a Article£¬once mentioned of 78364-55-3, name: 6-Fluoro-2-hydrazinylbenzo[d]thiazole

In attempt to make significant pharmacologically active molecule, we report here the synthesis and in vitro antimicrobial and antitubercular activity of various series of 3-(3-pyridyl)-5-(4-nitrophenyl)-4-(N-substituted-1,3- benzothiazol-2-amino)-4H-1,2,4-triazole. The antimicrobial activity of title compounds were examined against two Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), two Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), and three fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) using the broth microdilution method and antitubercular activity H37Rv using Lowenstein-Jensen agar method.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 78364-55-3 is helpful to your research., name: 6-Fluoro-2-hydrazinylbenzo[d]thiazole

Reference£º
Thiazole | C3H7041NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.78364-55-3, Name is 6-Fluoro-2-hydrazinylbenzo[d]thiazole, molecular formula is C7H6FN3S. In a Article£¬once mentioned of 78364-55-3, SDS of cas: 78364-55-3

The triazole analogs were obtained via. multistep synthesis sequence beginning with ethyl nicotinoate 3 which on treatment with hydrazine hydrate yields nicotinoyl hydrazide 4. Intermolecular cyclisation of 4 with 4-methylbenzoic acid in presence of phosphorous oxy chloride affords 2-(3-pyridyl)-5-(4-methylphenyl)-1,3,4-oxadiazole 5. Condensation of 5 with various substituted 2-hydrazino benzothiazole 2a-j results in 3-(3-pyridyl)-5-(4-methylphenyl)-4-(N-substituted-1,3-benzothiazol-2-amino) -4H-1,2,4-triazole 6a-j analogs. All the compounds have been characterized by elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. In vitro antitubercular activity was carried out against Mycobacterium tuberculosis H37Rv strain using Lowenstein-Jensen medium and antimicrobial activity against various bacteria and fungi using broth microdilution method. Compounds 2e, 6a, 6b, 6c, 6d, 6g, 6h and 6i emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antituberculars. Compound 6j showed better antitubercular activity compared to rifampicin. 3-(3-Pyridyl)-5-(4-methylphenyl) -4-(N-substituted-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 6a-j were synthesized and their antitubercular activity against H37Rv and antimicrobial activities have been tested.

The triazole analogs were obtained via. multistep synthesis sequence beginning with ethyl nicotinoate 3 which on treatment with hydrazine hydrate yields nicotinoyl hydrazide 4. Intermolecular cyclisation of 4 with 4-methylbenzoic acid in presence of phosphorous oxy chloride affords 2-(3-pyridyl)-5-(4-methylphenyl)-1,3,4-oxadiazole 5. Condensation of 5 with various substituted 2-hydrazino benzothiazole 2a-j results in 3-(3-pyridyl)-5-(4-methylphenyl)-4-(N-substituted-1,3-benzothiazol-2-amino) -4H-1,2,4-triazole 6a-j analogs. All the compounds have been characterized by elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. In vitro antitubercular activity was carried out against Mycobacterium tuberculosis H37Rv strain using Lowenstein-Jensen medium and antimicrobial activity against various bacteria and fungi using broth microdilution method. Compounds 2e, 6a, 6b, 6c, 6d, 6g, 6h and 6i emerged as promising antimicrobials. It was also observed that the promising antimicrobials have proved to be better antituberculars. Compound 6j showed better antitubercular activity compared to rifampicin. 3-(3-Pyridyl)-5-(4-methylphenyl) -4-(N-substituted-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 6a-j were synthesized and their antitubercular activity against H37Rv and antimicrobial activities have been tested.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 78364-55-3 is helpful to your research., SDS of cas: 78364-55-3

Reference£º
Thiazole | C3H7029NS – PubChem,
Thiazole | chemical compound | Britannica

Application of 78364-55-3. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 78364-55-3, Name is 6-Fluoro-2-hydrazinylbenzo[d]thiazole. In a document type is Article, introducing its new discovery.

A new series of (E)-1-((1-(6-chlorobenzo[d]thiazol-2-yl)-3-phenyl-1H- pyrazol-4-yl)methylene)-2-(6-substitutedbenzo[d]thiazol-2- yl)hydrazine derivatives (6a-6e) were synthesized and the structure of all the compounds was confirmed by IR, 1H NMR and mass spectral analysis. All the newly synthesized compounds were evaluated for anthelmintic activity against earthworm species (Eudrilus eugeniae and Megascolex konkanensis) and the insecticidal activity was carried out against termites (Coptotermis formasanus) using chloropyrifos as the standard drug.

A new series of (E)-1-((1-(6-chlorobenzo[d]thiazol-2-yl)-3-phenyl-1H- pyrazol-4-yl)methylene)-2-(6-substitutedbenzo[d]thiazol-2- yl)hydrazine derivatives (6a-6e) were synthesized and the structure of all the compounds was confirmed by IR, 1H NMR and mass spectral analysis. All the newly synthesized compounds were evaluated for anthelmintic activity against earthworm species (Eudrilus eugeniae and Megascolex konkanensis) and the insecticidal activity was carried out against termites (Coptotermis formasanus) using chloropyrifos as the standard drug.

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Reference£º
Thiazole | C3H7054NS – PubChem,
Thiazole | chemical compound | Britannica

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 78364-55-3, Name is 6-Fluoro-2-hydrazinylbenzo[d]thiazole, Recommanded Product: 6-Fluoro-2-hydrazinylbenzo[d]thiazole.

Treatment of 1,1,1-trifluoromethyl-3-cyano-3-phenylpropanone (1) with several heteroarylhydrazines (2a-e) in refluxing ethanol affords 1-heteroaryl-5-amino-4-phenyl-3-trifluoromethylpyrazoles (4) in a regioselective manner. The location of trifluoromethyl group at position-3 was established by a combined use of 13C and 19F NMR spectroscopy. The reaction proceeds through the intermediacy of the hydrazone which was isolated and characterized in one case (3e) by performing the reaction at room temperature. The compounds 3e and 4 were tested for their antibacterial property against six Gram-positive and three Gram-negative bacteria. Two compounds, namely 1-(benzothiazol-2?-yl)-5-amino-4-phenyl-3-trifluoromethylpyrazole (4a) and 1-(6?-methylbenzothiazol-2?-yl)-5-amino-4-phenyl-3- trifluoromethylpyrazole (4b) have displayed antibacterial activity comparable to the commercial antibiotics.

Treatment of 1,1,1-trifluoromethyl-3-cyano-3-phenylpropanone (1) with several heteroarylhydrazines (2a-e) in refluxing ethanol affords 1-heteroaryl-5-amino-4-phenyl-3-trifluoromethylpyrazoles (4) in a regioselective manner. The location of trifluoromethyl group at position-3 was established by a combined use of 13C and 19F NMR spectroscopy. The reaction proceeds through the intermediacy of the hydrazone which was isolated and characterized in one case (3e) by performing the reaction at room temperature. The compounds 3e and 4 were tested for their antibacterial property against six Gram-positive and three Gram-negative bacteria. Two compounds, namely 1-(benzothiazol-2?-yl)-5-amino-4-phenyl-3-trifluoromethylpyrazole (4a) and 1-(6?-methylbenzothiazol-2?-yl)-5-amino-4-phenyl-3- trifluoromethylpyrazole (4b) have displayed antibacterial activity comparable to the commercial antibiotics.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 6-Fluoro-2-hydrazinylbenzo[d]thiazole. In my other articles, you can also check out more blogs about 78364-55-3

Reference£º
Thiazole | C3H7026NS – PubChem,
Thiazole | chemical compound | Britannica

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 78364-55-3, C7H6FN3S. A document type is Article, introducing its new discovery., COA of Formula: C7H6FN3S

The regioselective synthesis of 1-heteroaryl-5-amino-4-phenylpyrazoles 3a-g and 1-heteroaryl-5-amino-3-methyl-4-phenylpyrazoles 3h-n was achieved by the treatment of heteroarylhydrazines 1a-g with alpha-phenylformylacetonitrile 2a and alpha-phenylacetylacetonitrile 2b, respectively. The structures of the compounds 3 were established by the combined use of 1H and 13C NMR spectroscopy. All the fourteen compounds were tested for their in vitro antibacterial activity against three Gram-positive and two Gram-negative bacteria. Six compounds 3a, 3d, 3e, 3g, 3l, and 3n from this series were found to be equipotent or more potent than the commercial antibiotics (Linezolid and Cefroxime axetil).

The regioselective synthesis of 1-heteroaryl-5-amino-4-phenylpyrazoles 3a-g and 1-heteroaryl-5-amino-3-methyl-4-phenylpyrazoles 3h-n was achieved by the treatment of heteroarylhydrazines 1a-g with alpha-phenylformylacetonitrile 2a and alpha-phenylacetylacetonitrile 2b, respectively. The structures of the compounds 3 were established by the combined use of 1H and 13C NMR spectroscopy. All the fourteen compounds were tested for their in vitro antibacterial activity against three Gram-positive and two Gram-negative bacteria. Six compounds 3a, 3d, 3e, 3g, 3l, and 3n from this series were found to be equipotent or more potent than the commercial antibiotics (Linezolid and Cefroxime axetil).

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Reference£º
Thiazole | C3H7030NS – PubChem,
Thiazole | chemical compound | Britannica