Downstream synthetic route of 81569-46-2

81569-46-2 Methyl 2-bromo-5-ethylthiazole-4-carboxylate 13015592, athiazole compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81569-46-2,Methyl 2-bromo-5-ethylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

81569-46-2, 4-(5-ethyl-4-(methoxycarbonyl)-1,3-thiazol-2-yl)benzoic acid The desired product was prepared by substituting methyl 2-bromo-5-ethylthiazole-4-carboxylate (prepared according to the procedure described in J. Chem. Soc. Perkin I 1982, 159-164) for 6-bromoindole in Example 4A.

81569-46-2 Methyl 2-bromo-5-ethylthiazole-4-carboxylate 13015592, athiazole compound, is more and more widely used in various fields.

Reference:
Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/55631; (2002); A1;; ; Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/86887; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica