Category: 859522-19-3

On January 18, 2007, Murray, Anthony; Lau, Jesper; Vedsoe, Per; Jeppesen, Lone; Kristiansen, Marit published a patent.Related Products of 859522-19-3 The title of the patent was Preparation of dicycloalkylcarbamoyl ureas as glucokinase activators. And the patent contained the following:

Title compounds represented by the formula I [wherein R1 = (cycloalkyl)alkyl, cycloalkyl, heterocyclyl, etc.; R2 = cycloalkyl, cycloalkenyl, heterocyclyl, etc.; R3 = H, alkyl, alkenyl, etc.; R4 = H, (cyclo)alkyl, arylalkyl, etc.; and pharmaceutically acceptable salts thereof] were prepared as glucokinase activators. For example, reaction of dicyclohexyl carbamoyl chloride with methylurea in THF gave II. The glucose sensitivity of I are measured at a compound concentration of 10 μM and at glucose concentrations of 5 and 15 mM. I and their pharmaceutical compositions are useful as activators of glucokinase for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Related Products of 859522-19-3

The Article related to dicycloalkylcarbamoyl urea preparation glucokinase activator, Alicyclic Compounds: Cyclohexanes and other aspects.Related Products of 859522-19-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 16, 2011, Murray, Anthony; Lau, Jesper; Vedso, Per; Jeppesen, Lone; Kristiansen, Marit published a patent.Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate The title of the patent was Dicycloalkylcarbamoyl ureas as glucokinase activators. And the patent contained the following:

This invention relates to dicycloalkylcarbamoyl ureas of formula (I), which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

The Article related to dicycloalkylcarbamoyl urea preparation glucokinase activator, Alicyclic Compounds: Cyclohexanes and other aspects.Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 26, 2015, Lin, Songnian; Parmee, Emma R.; Xu, Jiayi published a patent.Application In Synthesis of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate The title of the patent was Novel 2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment. And the patent contained the following:

Novel pyridine-2-carboxamide derivatives of formula I and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are effective as glucokinase activating agents. Pharmaceutical compositions and methods of treatment are also included. The present invention relates to novel pyridine-2-carboxamide derivatives and salts thereof which are effective as glucokinase activating agents. Moreover, it relates to compositions containing such compounds, and methods of treatment. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Application In Synthesis of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

The Article related to pyridinecarboxamide preparation glucokinase activator antidiabetic antiobesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 26, 2014, Parmee, Emma R.; Xu, Jiayi published a patent.Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate The title of the patent was Preparation of novel 2-pyridinecarboxamide derivatives as glucokinase activators useful in treating diseases. And the patent contained the following:

The title compounds I [R1, R2 = (un)substituted 6-10 membered aryl, 5-10 membered heteroaryl, 5-7 membered cycloalkyl, or 5-7 membered aliphatic heterocyclic group; ring A = (un)substituted 5-7 membered monocyclic or 9-10 membered bicyclic heteroaryl group in which the carbon atom attached to the amide nitrogen atom contained in formula I forms C:N together with the nitrogen atom in the ring; L = alkyl, alkoxyalkyl, alkoxy, etc.; T = CO2R, COR3R4, P(O)(OR5)2; R, R3-R5 = H or alkyl] that are effective as glucokinase activating agents, and useful for treating or preventing type 2 diabetes and similar conditions, were prepared E.g., a multi-step synthesis of II, starting from 6-chloro-3-fluoropyridine-2-carboxylic acid, was described. The GK activation capability of the exemplified compounds I was determined (data given). Pharmaceutical compositions and methods of treatment were also included. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

The Article related to pyridinecarboxamide preparation glucokinase activator antidiabetic antiobesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 21, 2005, Murray, Anthony; Lau, Jesper; Jeppesen, Lone; Vedso, Per; Ankersen, Michael; Lundbeck, Jane Marie; Kristiansen, Marit; Valcarce-Lopez, Maria Carmen; Polisetti, Dharma Rao; Subramanian, Govindan; Andrews, Robert Carl; Christen, Daniel P.; Cooper, Jeremy T.; Santhosh, Kalpathy Chidambareswaran published a patent.Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate The title of the patent was Preparation of heteroaryl ureas and their use as glucokinase activators. And the patent contained the following:

Title compounds I [wherein R1, R2 = (un)substituted cycloalk(en)yl, heterocyclyl or heterocycloalkenyl; A = (un)substituted heteroaryl, or pharmaceutically acceptable salts, stereoisomers and tautomers thereof] were prepared For example, treatment of 2-aminothiazole with carbonyldiimidazole followed by condensation with dicyclohexylamine gave urea II. The invented compounds are activators of glucokinase, and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial (no data). The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

The Article related to urea heteroaryl preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Safety of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 8, 2007, Murray, Anthony; Lau, Jesper; Jeppesen, Lone; Vedsoe, Per published a patent.Related Products of 859522-19-3 The title of the patent was Preparation of thiazolyl benzamides as glucokinase activators. And the patent contained the following:

Title compounds [I; m = 0-2; n = 0-4; R1 = OH, hydroxyalkyl, fluoroalkyl, Cll, F, Br, iodo, alkyl, alkenyl, alkynyl, amino, cyano, Ph, (substituted) heterocyclyl, etc.; R2 = YX; X = OZ, OZOZ, CO2Z, SZ, SOZ, SO2Z, etc.; Z, Z1 = bond, alkenylene, etc.; Y = (substituted) QZ1, etc.; Q = aryl, heterocyclyl, cycloalkyl; B = substituted 5-10 membered heterocyclyl], were prepared as glucokinase activators (no data). Thus, title compound Me [2-(3-isopropoxy-5-phenoxybenzoylamino)thiaol-5-ylsulfanyl]acetate was prepared in 4 steps from Me 3-isopropoxy-5-hydroxybenzoate, phenylboronic acid, 5-bromo-2-aminothiazole, 3-isopropoxy-5-phenoxybenzoic acid, and Me mercaptoacetate. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Related Products of 859522-19-3

The Article related to thiazolyl benzamide preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 859522-19-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 18, 2007, Lau, Jesper; Murray, Anthony; Vedsoe, Per; Kristiansen, Marit; Jeppesen, Lone published a patent.Category: thiazole The title of the patent was Preparation of cyclohexyl thiazolyl ureas as glucokinase activators. And the patent contained the following:

Title compounds represented by the formula R1R2NCONHA [wherein R1 = (cycloalkyl)alkyl, cycloalkyl, heterocyclyl, etc.; R2 = (cyclo)alkyl, cycloalkenyl, heterocyclyl, etc.; A = (un)substituted heteroaryl; and pharmaceutically acceptable salts, optical isomers or tautomers thereof] were prepared as glucokinase activators. For example, reductive condensation of phenethylamine with cyclohexanone, followed by coupling reaction with Et (2-aminothiazol-5-ylsulfanyl)acetate in the presence of 1,1′-carbonyldiimidazole and hydrolysis, gave I. The glucose sensitivity of the title compounds are measured at a compound concentration of 10 μM and at glucose concentrations of 5 and 15 mM. The title compounds are useful as activators of glucokinase for the treatment of various diseases, e.g. for the treatment of type 2 diabetes (no data). The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Category: thiazole

The Article related to cyclohexyl thiazolyl urea preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 18, 2007, Murray, Anthony; Lau, Jesper; Vedsoe, Per; Kristiansen, Marit; Jeppesen, Lone published a patent.Related Products of 859522-19-3 The title of the patent was Preparation of dicycloalkyl thiazolyl ureas as glucokinase activators. And the patent contained the following:

Title compounds represented by the formula R1R2NCONHA [wherein R1 = (un)substituted cyclohexyl; R2 = cyclohexyl; A = (un)substituted thiazolyl; and pharmaceutically acceptable salts, optical isomers or tautomers thereof] were prepared as glucokinase activators. For example, reaction of 2-aminothiazole with dicyclopentylamine and carbonyldiimidazole gave I. The glucose sensitivity of the title compounds are measured at a compound concentration of 10 μM and at glucose concentrations of 5 and 15 mM. The title compounds are useful as activators of glucokinase for the treatment of diabetes (no data). The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Related Products of 859522-19-3

The Article related to dicycloalkyl thiazolyl urea preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 859522-19-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 1, 2009, Murray, Anthony; Lau, Jesper; Vedso, Per; Kristiansen, Marit; Jeppesen, Lone published a patent.SDS of cas: 859522-19-3 The title of the patent was Preparation of dicycloalkyl thiazolyl ureas as glucokinase activators. And the patent contained the following:

Title compounds represented by the formula R1R2NCONHA [wherein R1 = (un)substituted cyclohexyl; R2 = cyclohexyl; A = (un)substituted thiazolyl; and pharmaceutically acceptable salts, optical isomers or tautomers thereof] were prepared as glucokinase activators. For example, reaction of 2-aminothiazole with dicyclopentylamine and carbonyldiimidazole gave I. The glucose sensitivity of the title compounds are measured at a compound concentration of 10 μM and at glucose concentrations of 5 and 15 mM. The title compounds are useful as activators of glucokinase for the treatment of various diseases such as diabetes (no data). The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).SDS of cas: 859522-19-3

The Article related to dicycloalkyl thiazolyl urea preparation glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.SDS of cas: 859522-19-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 3, 2012, Jeppesen, Lone; Kristiansen, Marit published a patent.Quality Control of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate The title of the patent was Heteroaromatic glucokinase activators. And the patent contained the following:

The present invention describes 2,3-di-substituted N-heteroaromatic propionamides, of Formula (I) wherein the substitution at the 3-position is an optionally substituted Ph ring and the substitution at the 2-position is an alkyl or cycloalkyl group; pharmaceutical compositions comprising the same; and, methods of using the same. The propionamides are glucokinase activators for the treatment of type II diabetes. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Quality Control of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

The Article related to heteroaromatic propionamide preparation glucokinase activator diabetes treatment, metabolic disorder treatment heteroaromatic propionamide glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica