Category: 86978-24-7

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.86978-24-7, Name is (Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)pent-2-enoic acid, molecular formula is C13H18N2O4S. In a Patent，once mentioned of 86978-24-7, Safety of (Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)pent-2-enoic acid

The present invention provides a process for the preparation of the compound of formula (I) and its salt and esters. More particularly, this present invention relates to an improved process for the preparation Cefcapene of formula (I) and its salt and esters.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 86978-24-7 is helpful to your research., Safety of (Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)pent-2-enoic acid

Reference：
Thiazole | C3H98NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.86978-24-7, Name is (Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)pent-2-enoic acid, molecular formula is C13H18N2O4S. In a Patent£¬once mentioned of 86978-24-7, Recommanded Product: (Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)pent-2-enoic acid

The present invention provides a kind of hydrochloric acid […] intermediate BCN of the preparation method, which belongs to the technical field of organic synthesis. The invention through the mixed anhydride prepared by the reaction of the mixed anhydride of the BAPA – MS with D – 7 – ACA – MG salt can by condensation reaction, through deferoxamine acylation reaction and salt forming crystallization, get hydrochloric acid […] intermediate BCN, preparation method of this invention the process route is short, high purity of the product, low cost, and is suitable for industrial production. The data show that the embodiment, of the invention the purity of the BCN […] hydrochloric acid intermediate can be as high as 98.84%, yield as high as 91.99%. (by machine translation)

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 86978-24-7 is helpful to your research., Recommanded Product: (Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)pent-2-enoic acid

Reference£º
Thiazole | C3H99NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 86978-24-7, Name is (Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)pent-2-enoic acid, molecular formula is C13H18N2O4S. In a Article£¬once mentioned of 86978-24-7, category: thiazole

A stereoselective or exclusive approach to a series of ethyl (Z)-2-(2-substituted-thiazol-4-yl)pent-2-enoates from ethyl (E/Z)-2-(2- bromoacetyl)pent-2-enoate and thioureas or thioamides was reported in good yields. This approach involves a quaternary carbon stereocontrolled cis-configuration formation, and opportunely blocking a potential E/Z isomerization. The practical applicability was highlighted by the synthesis of (Z)-2-(2-tert-butoxycarbonylaminothiazol-4-yl)pent-2-enoic acid, a commercially important side-chain material of cefcapene pivoxil, in a two-step procedure. Georg Thieme Verlag Stuttgart ¡¤ New York.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.category: thiazole. In my other articles, you can also check out more blogs about 86978-24-7

Reference£º
Thiazole | C3H109NS – PubChem,
Thiazole | chemical compound | Britannica

Electric Literature of 86978-24-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 86978-24-7, C13H18N2O4S. A document type is Patent, introducing its new discovery.

The invention relates to a head spore card side chain acid preparation method, which belongs to the technical field of pharmaceutical intermediates. The preparation method is under the protection of nitrogen to the alcohol in the organic solvent in a double-ketene, then instillment bromide reaction, adding methylene chloride and water mixed fluid quenching reaction, separating the organic phase, the organic phase is added to the acetic acid, after cooling at the same time dropping propionaldehyde and organic reaction catalyst A, then adding thiourea to react, by reduced pressure distillation to concentrate, the concentrated solution is added in dichloromethane, di-T-n-butyl and organic reaction catalyst B, then adding alkali to carry out the reaction, the temperature of the hydrochloric acid then drop crystallization, filtered, isopropyl alcohol aqueous solution and washing, and drying to obtain (Z)- 2 – (2 – tert-butoxycarbonyl amino thiazole – 4 – yl) – 2 – pentenoic acid, i.e. side chain acidspore card. The invention uses two-ketene as the starting material, less side reaction, high yield, high product purity, mild reaction conditions, more easy to realize industrial production. (by machine translation)

The invention relates to a head spore card side chain acid preparation method, which belongs to the technical field of pharmaceutical intermediates. The preparation method is under the protection of nitrogen to the alcohol in the organic solvent in a double-ketene, then instillment bromide reaction, adding methylene chloride and water mixed fluid quenching reaction, separating the organic phase, the organic phase is added to the acetic acid, after cooling at the same time dropping propionaldehyde and organic reaction catalyst A, then adding thiourea to react, by reduced pressure distillation to concentrate, the concentrated solution is added in dichloromethane, di-T-n-butyl and organic reaction catalyst B, then adding alkali to carry out the reaction, the temperature of the hydrochloric acid then drop crystallization, filtered, isopropyl alcohol aqueous solution and washing, and drying to obtain (Z)- 2 – (2 – tert-butoxycarbonyl amino thiazole – 4 – yl) – 2 – pentenoic acid, i.e. side chain acidspore card. The invention uses two-ketene as the starting material, less side reaction, high yield, high product purity, mild reaction conditions, more easy to realize industrial production. (by machine translation)

If you are hungry for even more, make sure to check my other article about 86978-24-7. Electric Literature of 86978-24-7

Reference£º
Thiazole | C3H101NS – PubChem,
Thiazole | chemical compound | Britannica

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 86978-24-7, Name is (Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)pent-2-enoic acid, molecular formula is C13H18N2O4S. In a Article£¬once mentioned of 86978-24-7, Application In Synthesis of (Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)pent-2-enoic acid

Synthesis and biological activity of a series of 7beta-[(Z)-2-(2-aminothiazol-4-yl)-3-(substituted)-2- propenoylamino]-3-cephem-4-carboxylic acids with C-3 substitutions and their pivaloyloxymethyl esters are described. These acid compounds exhibited potent antibacterial activity against both Gram-positive and Gram-negative bacteria. Pivaloyloxymethyl esters of selected compounds in this series were found to be well absorbed from small intestine in mice. Pivaloyloxymethyl 7beta-[(Z)-2-(2-aminothiazol-4-yl)-2-pentenoylamino]-3- carbamoyloxymethyl-3-cephem-4-carboxyiate hydrochloride hydrate (S-1108) was finally selected as the candidate for clinical evaluation.

Synthesis and biological activity of a series of 7beta-[(Z)-2-(2-aminothiazol-4-yl)-3-(substituted)-2- propenoylamino]-3-cephem-4-carboxylic acids with C-3 substitutions and their pivaloyloxymethyl esters are described. These acid compounds exhibited potent antibacterial activity against both Gram-positive and Gram-negative bacteria. Pivaloyloxymethyl esters of selected compounds in this series were found to be well absorbed from small intestine in mice. Pivaloyloxymethyl 7beta-[(Z)-2-(2-aminothiazol-4-yl)-2-pentenoylamino]-3- carbamoyloxymethyl-3-cephem-4-carboxyiate hydrochloride hydrate (S-1108) was finally selected as the candidate for clinical evaluation.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of (Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)pent-2-enoic acid. In my other articles, you can also check out more blogs about 86978-24-7

Reference£º
Thiazole | C3H106NS – PubChem,
Thiazole | chemical compound | Britannica

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 86978-24-7, C13H18N2O4S. A document type is Patent, introducing its new discovery., Application In Synthesis of (Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)pent-2-enoic acid

The invention discloses a preparation method of cefcapene pivoxil hydrochloride. The preparation method comprises the following steps: 1), a compound shown in the formula I is stirred and dissolved in pyridine, methanesulfonyl chloride is added and stirred for reaction, filtering is performed, and a liquid containing a compound shown in the formula II is obtained; 2), 7-ACA reacts with the liquid containing the compound shown in the formula II in the presence of proline and diisopropylamine, and a compound shown in the formula III is obtained; 3), the compound shown in the formula III reacts with potassium carbonate, and a compound shown in the formula IV is obtained; 4), the compound shown in the formula IV reacts with chlorosulfonyl isocyanate in the presence of diisopropylamine, and a compound shown in the formula V is obtained; 5), the compound shown in the formula V and obtained in the step 4) reacts with iodomethyl pivalate in DMF (dimethyl formamide) in the presence of potassium phosphate and copper acetate, a phosphate solution is added to end the reaction, and a compound shown in the formula VI is obtained; 6), cefcapene pivoxil hydrochloride is obtained after deprotection of the compound shown in the formula VI. The method increases product yield greatly and is particularly suitable for mass production, and few by-products are produced.

The invention discloses a preparation method of cefcapene pivoxil hydrochloride. The preparation method comprises the following steps: 1), a compound shown in the formula I is stirred and dissolved in pyridine, methanesulfonyl chloride is added and stirred for reaction, filtering is performed, and a liquid containing a compound shown in the formula II is obtained; 2), 7-ACA reacts with the liquid containing the compound shown in the formula II in the presence of proline and diisopropylamine, and a compound shown in the formula III is obtained; 3), the compound shown in the formula III reacts with potassium carbonate, and a compound shown in the formula IV is obtained; 4), the compound shown in the formula IV reacts with chlorosulfonyl isocyanate in the presence of diisopropylamine, and a compound shown in the formula V is obtained; 5), the compound shown in the formula V and obtained in the step 4) reacts with iodomethyl pivalate in DMF (dimethyl formamide) in the presence of potassium phosphate and copper acetate, a phosphate solution is added to end the reaction, and a compound shown in the formula VI is obtained; 6), cefcapene pivoxil hydrochloride is obtained after deprotection of the compound shown in the formula VI. The method increases product yield greatly and is particularly suitable for mass production, and few by-products are produced.

Interested yet? Keep reading other articles of 86978-24-7!, Application In Synthesis of (Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)pent-2-enoic acid

Reference£º
Thiazole | C3H102NS – PubChem,
Thiazole | chemical compound | Britannica