Category: 885465-97-4

885465-97-4, Name is 3-Thiazol-2-yl-benzaldehyde, molecular formula is C10H7NOS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 885465-97-4, Product Details of 885465-97-4

We have identified several series of small molecule inhibitors of TrkA with unique binding modes. The starting leads were chosen to maximize the structural and binding mode diversity derived from a high throughput screen of our internal compound collection. These leads were optimized for potency and selectivity employing a structure based drug design approach adhering to the principles of ligand efficiency to maximize binding affinity without overly relying on lipophilic interactions. This endeavor resulted in the identification of several small molecule pan-Trk inhibitor series that exhibit high selectivity for TrkA/B/C versus a diverse panel of kinases. We have also demonstrated efficacy in both inflammatory and neuropathic pain models upon oral dosing. Herein we describe the identification process, hit-to-lead progression, and binding profiles of these selective pan-Trk kinase inhibitors.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Product Details of 885465-97-4. In my other articles, you can also check out more blogs about 885465-97-4

Reference：
Thiazole | C3H4560NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 885465-97-4. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 885465-97-4, Name is 3-Thiazol-2-yl-benzaldehyde. In a document type is Patent, introducing its new discovery.

The present invention is directed to benzyl urea compounds, which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.

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Reference：
Thiazole | C3H4562NS – PubChem,
Thiazole | chemical compound | Britannica

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.885465-97-4, Name is 3-Thiazol-2-yl-benzaldehyde, molecular formula is C10H7NOS. In a Patent，once mentioned of 885465-97-4, name: 3-Thiazol-2-yl-benzaldehyde

The present invention provides a novel indole derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof. The compound according to the present invention can selectively inhibit histone deacetylase (HDAC), and thus can be used to effectively treat a disease associated with histone deacetylase (HDAC) activity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.name: 3-Thiazol-2-yl-benzaldehyde, you can also check out more blogs about885465-97-4

Reference：
Thiazole | C3H4561NS – PubChem,
Thiazole | chemical compound | Britannica

In an article, published in an article, once mentioned the application of 885465-97-4, Name is 3-Thiazol-2-yl-benzaldehyde,molecular formula is C10H7NOS, is a conventional compound. this article was the specific content is as follows.Quality Control of: 3-Thiazol-2-yl-benzaldehyde

The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds

A focused library of rhodanine compounds containing novel substituents at the C5-position was synthesized and tested in vitro against a panel of clinically relevant MRSA strains. The present SAR study was based on our lead compound 1 (MIC = 1.95 mug/mL), with a focus on identifying optimal C5-arylidene substituents. In order to obtain this objective, we condensed several unique aromatic aldehydes with phenylalanine-derived rhodanine intermediates to obtain C5-substituted target rhodanine compounds for evaluation as anti-MRSA compounds. These efforts produced three compounds with significant efficacy: 23, 32 and 44, with MIC values ranging from 0.98 to 1.95 mug/mL against all tested MRSA strains as compared to the reference antibiotics penicillin G (MIC = 15.60-250.0 mug/mL) and ciprofloxacin (MIC = 7.80-62.50 mug/mL) and comparable to that of vancomycin (MIC = 0.48 mug/mL). In addition, compounds 24, 28, 37, 41, 46 and 48 (MIC = 1.95-3.90 mug/mL) were efficacious against all MRSA strains. The majority of the synthesized compounds had bactericidal activity at concentrations only two to fourfold higher than their MIC. Overall, the results suggest that compounds 23, 32 and 44 may be of potential use in the treatment of MRSA infections.

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Reference：
Thiazole | C3H4563NS – PubChem,
Thiazole | chemical compound | Britannica