Category: 915030-08-9

Reference of 915030-08-9. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 915030-08-9, Name is 2-(Trifluoromethyl)thiazole-4-carboxylic acid

The invention relates to compounds of Formula (I) wherein X, Y, R1, R2, R3, R4 and R5 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

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Reference：
Thiazole | C3H1015NS – PubChem,
Thiazole | chemical compound | Britannica

Synthetic Route of 915030-08-9. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 915030-08-9, Name is 2-(Trifluoromethyl)thiazole-4-carboxylic acid. In a document type is Patent, introducing its new discovery.

The invention relates to compounds of Formula (I), wherein X, R1A, R1B and R2 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

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Reference：
Thiazole | C3H1014NS – PubChem,
Thiazole | chemical compound | Britannica

Reference of 915030-08-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 915030-08-9, Name is 2-(Trifluoromethyl)thiazole-4-carboxylic acid, molecular formula is C5H2F3NO2S. In a Patent£¬once mentioned of 915030-08-9

The invention provides a compound of formula (I) or a salt thereof: wherein R2 is H, C1-3alkyl, n-butyl, C1-2fluoroalkyl, cyclopropyl, cyclobutyl, (cyclopropyl)methyl-, ?CN, or ?CH2OH; R3 is inter alia optionally substituted C4-7cycloalkyl or an optionally substituted heterocyclic group (aa), (bb) or (cc); Ra is H, methyl or ethyl; Rb is H or methyl; R4 is H, methyl, ethyl, n-propyl, ?C(O)-Me, or ?C(O)?C1fluoroalkyl; and R5 is: ?C(O)?(CH2)n?Ar, ?C(O)-Het, ?C(O)?C1-6alkyl, ?C(O)?C1 fluoroalkyl, ?C(O)?(CH2)2?C(O)?NR15bNR15b, ?C(O)?CH2?C(O)?NR15bNR15b, ?C(O)?NR15b?(CH2)m1?Ar, ?C(O)?NR15b?Het, ?C(O)?NR15b?C1-6alkyl, ?C(O)?NR5aR5b, ?S(O)2?(CH2)m2?Ar, ?S(O)2-Het, ?S(O)2?C1-6alkyl, or ?CH2?Ar; or R4 and R5 taken together are ?(CH2)p1?, ?(CH2)2?X5?(CH2)2?, ?C(O)?(CH2)p2?, ?C(O)?N(R15)?(CH2)p3?; or NR4R5 is of sub-formula (y), (y1), (y2) or (y3). The invention provides the use of the compounds as inhibitors of phosphodiesterase type IV (PDE4) and/or for the treatment and/or prophylaxis of inflammatory and/or allergic diseases such as COPD and the like.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 915030-08-9 is helpful to your research., Reference of 915030-08-9

Reference£º
Thiazole | C3H1016NS – PubChem,
Thiazole | chemical compound | Britannica

915030-08-9,915030-08-9, 2-(Trifluoromethyl)thiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-(trifluoromethyl)thiazole-4-carboxylic acid (1.0 g, 5.07 mmol) in DMF (15 mL) were added 1-propanephosphonic anhydride (6.34 mL, 10.15 mmol, 50% in ethyl acetate), followed by DIPEA (2.66 mL, 15.22 mmol) and N,O- dimethylhydroxylamine hydrochloride (0.99 g, 10.15 mmol) at room temperature. The reaction mixture was stirred for 5 h. The reaction mixture was concentrated under reduced pressure to remove volatiles and the crude product was dissolved in ethyl acetate (150 mL), washed with water (100 mL), the aqueous layer was back extracted with ethyl acetate (50 mL x 2) and the combined organic layer was washed with brine, dried over anhydrous Na2SO4, concentrated under reduced pressure to obtain the crude product, which was purified by silica gel chromatography (1-5% methanol/chloroform; 40 g column) to afford N-methoxy-N-methyl-2-(trifluoromethyl)thiazole-4-carboxamide (925 mg, 76 % yield). LCMS: m/z = 241.1 (M+H); retention time 1.17 min [LCMS method: Column: Waters Acquity UPLC BEH C18 (2.1 x 50 mm) 1.7 mm, Mobile phase A: 10 mM NH4OAc:acetonitrile (95:5); Mobile phase B: 10 mM NH4OAc:acetonitrile (5:95), Gradient = 20-90 % B over 1.1 minute, then a 0.6 minute hold at 90 % B; Temperature: 50 C; Flow rate: 0.7 mL/min; Detection: UV at 220 nm].

The synthetic route of 915030-08-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; VELAPARTHI, Upender; CHUPAK, Louis S.; DARNE, Chetan Padmakar; DING, Min; GENTLES, Robert G.; HUANG, Yazhong; KAMBLE, Manjunatha Narayana Rao; MARTIN, Scott W.; MANNOORI, Raju; MCDONALD, Ivar M.; OLSON, Richard E.; RAHAMAN, Hasibur; JALAGAM, Prasada Rao; ROY, Saumya; TONUKUNURU, Gopikishan; VELAIAH, Sivasudar; WARRIER, Jayakumar Sankara; ZHENG, Xiaofan; TOKARSKI, John S.; DASGUPTA, Bireshwar; REDDY, Kotha Rathnakar; RAJA, Thiruvenkadam; (0 pag.)WO2020/6018; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica