Category: 92-36-4

On May 31, 2007, Ichihara, Osamu; Sampson, David; Whittaker, Mark; Bradley, Mark; Cho, Jin Ku published an article.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was Development of self-indicating resin. And the article contained the following:

The development and application of self-indicating resins (SIR), materials which can indicate the presence or absence of amines in the reaction solution by the conspicuous color change of a phenolsulfophthalein type dye immobilized on resin beads has been reported. Although the functionality necessary for attaching the dye to the resins could be readily introduced by the Suzuki-Miyaura coupling during the synthesis of the SIR, this approach was only applicable to the dyes containing suitable functionality for the cross-coupling reaction. A new approach to immobilizing the indicating dyes onto the resin support is now reported. The dyes suitable for loading onto aminomethyl polystyrene (PS) resin were prepared by Friedel-Crafts reaction of 2-sulfoterephthalic anhydride with a wide range of phenols. Using this new route, polymer-supported dye I was readily prepared in >100g quantities. Use of I in the synthesis of a 144 member urea library was demonstrated and the SIR successfully indicated the endpoint of the reaction between amines and isocyanates. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to urea preparation sulfonephenolphthalein polymer supported indicator, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 30, 2003, Mattioni, Brian E.; Kauffman, Gregory W.; Jurs, Peter C.; Custer, Laura L.; Durham, Stephen K.; Pearl, Greg M. published an article.Formula: C14H12N2S The title of the article was Predicting the Genotoxicity of Secondary and Aromatic Amines Using Data Subsetting To Generate a Model Ensemble. And the article contained the following:

Binary quant. structure-activity relationship (QSAR) models are developed to classify a data set of 334 aromatic and secondary amine compounds as genotoxic or nongenotoxic based on information calculated solely from chem. structure. Genotoxic endpoints for each compound were determined using the SOS Chromotest in both the presence and absence of an S9 rat liver homogenate. Compounds were considered genotoxic if assay results indicated a pos. genotoxicity hit for either the S9 inactivated or S9 activated assay. Each compound in the data set was encoded through the calculation of numerical descriptors that describe various aspects of chem. structure (e.g. topol., geometric, electronic, polar surface area). Furthermore, five addnl. descriptors that focused on the secondary and aromatic nitrogen atoms in each mol. were calculated specifically for this study. Descriptor subsets were examined using a genetic algorithm search engine interfaced with a k-Nearest Neighbor fitness evaluator to find the most information-rich subsets, which ultimately served as the final predictive models. Models were chosen for their ability to minimize the total number of misclassifications, with special attention given to those models that possessed fewer occurrences of pos. toxicity hits being misclassified as nontoxic (false negatives). In addition, a subsetting procedure was used to form an ensemble of models using different combinations of compounds in the training and prediction sets. This was done to ensure that consistent results could be obtained regardless of training set composition The procedure also allowed for each compound to be externally validated three times by different training set data with the resultant predictions being used in a “majority rules” voting scheme to produce a consensus prediction for each member of the data set. The individual models produced an average training set classification rate of 71.6% and an average prediction set classification rate of 67.7%. However, the model ensemble was able to correctly classify the genotoxicity of 72.2% of all prediction set compounds The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Formula: C14H12N2S

The Article related to genotoxicity structure activity relationship secondary aromatic amine, qsar algorithm mol descriptor aromatic amine genotoxicity, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Formula: C14H12N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sun, Xin; Li, Qian; Xiang, Junfeng; Wang, Lixia; Zhang, Xiufeng; Lan, Ling; Xu, Shujuan; Yang, Fengmin; Tang, Yalin published an article in 2017, the title of the article was Novel fluorescent cationic benzothiazole dye that responds to G-quadruplex aptamer as a novel K+ sensor.Formula: C14H12N2S And the article contains the following content:

A fluorescent cationic benzothiazole dye (I) that selectively targets a G-quadruplex aptamer was designed and synthesized as a K+ sensor. The K+-driven aptamer sensor is based on the strategy of conformational transition from single-stranded DNA to G-quadruplex structure, leading to an amplified fluorescence signal in the reporter. This fluorescent sensor displayed high selectivity for K+, suggesting great potential for practical applications. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Formula: C14H12N2S

The Article related to fluorescent cationic benzothiazole dye g quadruplex aptamer potassium sensor, Biochemical Methods: Spectral and Related Methods and other aspects.Formula: C14H12N2S

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Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 28, 2008, Du, Hongying; Wang, Jie; Watzl, June; Zhang, Xiaoyun; Hu, Zhide published an article.Electric Literature of 92-36-4 The title of the article was Classification structure-activity relationship (CSAR) studies for prediction of genotoxicity of thiophene derivatives. And the article contained the following:

The grid search support vector machine (GS-SVM) was used to build a classification structure-activity relationship (CSAR) model and to predict the genotoxicity property of 140 thiophene derivatives with the information derived from the compounds’ mol. structures. The seven descriptors selected by linear discriminant anal. (LDA) were used as the inputs to develop the GS-SVM model. Using the Grid Search method, a satisfactory model with a good predictive capability was obtained. The quality of the models was evaluated by the number of right classified compounds The total accuracy of the LDA model was 81.4% and 85.2% for the training set and test set, resp., and to the GS-SVM model was 92.9% and 92.6%, resp. It was proved that the GS-SVM method was a very useful modeling approach with good classification ability for the genotoxicity of the thiophene derivatives This work also provides a new idea and an alternative method to investigate the genotoxicity of the similar structures with thiophene derivatives, and can be extended to other toxicity studies. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Electric Literature of 92-36-4

The Article related to thiophene derivative genotoxicity classification structure activity, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Electric Literature of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 20, 2003, Karlsson, H. Jonas; Lincoln, Per; Westman, Gunnar published an article.HPLC of Formula: 92-36-4 The title of the article was Synthesis and DNA binding studies of a new asymmetric cyanine dye binding in the minor groove of [poly(dA-dT)]2. And the article contained the following:

A new asym. cyanine dye has been synthesized and its interaction with different DNA has been investigated. In this dye, BEBO, the structure of the known intercalating cyanine dye BO has been extended with a benzothiazole substituent. The resulting crescent-shape of the mol. is similar to that of the well-known minor groove binder Hoechst 33258. Indeed, comparative studies of BO illustrate a considerable change in binding mode induced by this structural modification. Linear and CD studies indicate that BEBO binds in the minor groove to [poly (dA-dT)]2, but that the binding to calf thymus DNA is heterogeneous, although still with a significant contribution of minor groove binding. Similar to other DNA binding asym. cyanine dyes, BEBO has a large increase in fluorescence intensity upon binding and a relatively large quantum yield when bound. The minor groove binding of BEBO to [poly (dA-dT)]2 affords roughly a 180-fold increase in intensity, which is larger than to that of the commonly used minor groove binding probes DAPI and Hoechst 33258. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).HPLC of Formula: 92-36-4

The Article related to dna cyanine dye preparation, Biochemical Methods: Spectral and Related Methods and other aspects.HPLC of Formula: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kucukbay, F. Zehra; Bugday, Nesrin; Kucukbay, Hasan; Tanc, Muhammet; Supuran, Claudiu T. published an article in 2016, the title of the article was Synthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivatives.Electric Literature of 92-36-4 And the article contains the following content:

N-protected amino acids I [Pg = Cbz, Boc, R = H, Me; Pg =Boc, R = CH2Ph] were reacted with substituted benzothiazoles to give the corresponding N-protected amino acid-benzothiazole conjugates II [Pg = Cbz, R = H; Pg = Boc, R = H, CH2Ph], III [Pg = Cbz, R = H, Me; Pg = Boc, R = H, CH2Ph] and IV [Pg = CBz, R = H, Me; Pg = Boc, R = H, Me, CH2Ph] (60-89%). Their structures were confirmed by proton NMR (1H NMR), carbon-13 NMR (13C NMR), IR and elemental anal. Their carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activities were determined against two cytosolic human isoforms (hCA I and hCA II), one membrane-associated (hCA IV) and one transmembrane (hCA XII) enzyme by a stopped-flow CO2 hydrase assay method. The new compounds showed rather weak, micromolar inhibitory activity against most of these enzymes. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Electric Literature of 92-36-4

The Article related to amino acid benzothiazole amide preparation carbonic anhydrase inhibition, amino acid-benzothiazole conjugates, benzothiazole, carbonic anhydrase, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Electric Literature of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

White, Lisa J.; Boles, Jessica E.; Hilton, Kira L. F.; Ellaby, Rebecca J.; Hiscock, Jennifer R. published an article in 2020, the title of the article was Towards the application of supramolecular self-associating amphiphiles as next-generation delivery vehicles.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole And the article contains the following content:

Herein, we present a series of supramol. self-associating amphiphilic (SSA) salts and establish the potential for these mol. constructs to act as next-generation solution-state mol. delivery vehicles. We characterize the self-association of these SSAs, both alone and when co-formulated with a variety of drug(like) competitive guest species. Single crystal X-ray diffraction studies enable the observation of hydrogen-bonded self-association events in the solid state, while high resolution mass spectrometry confirms the presence of anionic SSA dimers in the gas-phase. These same anionic SSA dimeric species are also identified within a competitive organic solvent environment (DMSO-d6/0.5% H2O). However, extended self-associated aggregates are observed to form under aqueous conditions (H2O/5.0% EtOH) in both the absence and presence of these competitive guest species. Finally, through the completion of these studies, we present a framework to support others in the characterization of such systems. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to drug delivery self associating amphiphile, amphiphile, drug delivery, hydrogen bond, supramolecular chemistry, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 24, 2010, Tzanopoulou, Stamatia; Sagnou, Marina; Paravatou-Petsotas, Maria; Gourni, Eleni; Loudos, George; Xanthopoulos, Stavros; Lafkas, Daniel; Kiaris, Hippokratis; Varvarigou, Alexandra; Pirmettis, Ioannis C.; Papadopoulos, Minas; Pelecanou, Maria published an article.Application of 92-36-4 The title of the article was Evaluation of Re and 99mTc Complexes of 2-(4′-Aminophenyl)benzothiazole as Potential Breast Cancer Radiopharmaceuticals. And the article contained the following:

The synthesis of M(I)(CO)3(NNO) (M = Re, 99mTc) complexes conjugated to the antitumor agent 2-(4′-aminophenyl)benzothiazole and to its 6-Me derivative, as well as their in vitro and in vivo biol. evaluation as breast cancer radiopharmaceuticals, is reported. The Re complexes displayed under the fluorescence microscope clear uptake by the sensitive to the 2-(4′-aminophenyl)benzothiazole pharmacophore breast cancer cell lines MCF-7 and T47D, while uptake by less sensitive lines and by normal fibroblasts was much weaker. In accordance, uptake of the corresponding radioactive 99mTc complexes was clearly higher in the breast cancer cell lines MCF-7 and MDA-231 compared to normal fibroblasts. Biodistribution of the 99mTc complexes in SCID mice bearing MCF-7 xenografts showed appreciable tumor uptake. A tumor/muscle ratio of 2.2 was measured for the complex conjugated to 2-(4′-aminophenyl)benzothiazole that led to successful tumor imaging. The results render the 2-(4′-aminophenyl)benzothiazole complexes potential candidates for imaging (99mTc) and targeted radiotherapy (188Re) of breast cancer. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Application of 92-36-4

The Article related to rhenium technetium aminophenyl benzothiazole preparation breast cancer imaging radiotherapy, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Application of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2015, Ambure, Pravin; Roy, Kunal published an article.Category: thiazole The title of the article was Exploring Structural Requirements of Imaging Agents Against Aβ Plaques in Alzheimer’s Disease: A QSAR Approach. And the article contained the following:

Exploring mol. imaging agents against the beta amyloid (Aβ) plaques for an early detection of Alzheimer’s disease (AD) is one of the emerging research areas in medicinal chem. In the present in-silico study, a congeneric series of 44 imaging agents, including 17 positron emission tomog. (PET) and 27 single photon emission computed tomog. (SPECT) imaging agents, was utilized to understand the structural features required for having essential binding affinity against Aβ plaques. Here, 2D-quant. structure-activity relationship (2D-QSAR) and group-based QSAR (G-QSAR) models have been developed using genetic function approximation (GFA) and validated using various statistical metrics. Both the models showed satisfactory performance signifying the reliability and robustness of the developed QSAR models. The vital information gained from both the QSAR models will be useful in developing new PET and SPECT imaging agents and also in predicting their binding affinity against Aβ plaques. The results of this study would be important in view of the widespread clin. applicability of the SPECT imaging agents, especially in the developing countries. In this study, we have also designed some imaging agents based on the information provided by the models. Some of these designed compounds were predicted to be similar to or more active than the most active imaging agents present in the original dataset. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Category: thiazole

The Article related to amyloid beta plaque alzheimer disease radiodiagnostic pet spect qsar, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 15, 2010, Hu, Wan-Ping; Chen, Yin-Kai; Liao, Chao-Cheng; Yu, Hsin-Su; Tsai, Yi-Min; Huang, Shu-Mei; Tsai, Feng-Yuan; Shen, Ho-Chuan; Chang, Long-Sen; Wang, Jeh-Jeng published an article.COA of Formula: C14H12N2S The title of the article was Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents. And the article contained the following:

Photodynamic therapy (PDT) employing exogenous photosensitizers is currently being approved for treatment of basal cell carcinoma (BCC). 2-(4-Aminophenyl)benzothiazoles (6) consist of chromophoric structure and absorb light in the UVA (315-400 nm). These results encouraged us to design and synthesize a diversity of 2-phenylbenzothiazoles (6). Studies on the apoptotic mechanism involved in photosensitive effects induced by UVA-activated 6 in BCC cells are carried out in the present article. 6-UVA-treated cells displayed several features of apoptosis, including an increase in the sub-G1 population, a significantly increased annexin V binding, and activation of caspase-3. 6-UVA induced a decrease in mitochondrial membrane potential (Δψ mt) and ATP via enhanced ROS generation and promoted phosphorylation of extracellular signal-regulated kinase (ERK) and p38 MAPK expression. These results suggest that 6-UVA elicits photosensitive effects in mitochondria processes which involve ERK and p38 activation, and ultimately lead to BCC cell apoptosis. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).COA of Formula: C14H12N2S

The Article related to aminophenyl benzothiazole derivative preparation pdt photosensitizer, Radiation Biochemistry: Disease Diagnosis and Therapy and other aspects.COA of Formula: C14H12N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica