Category: 92-36-4

On May 29, 2013, Megill, Andrea; Lee, Taehee; DiBattista, Amanda Marie; Song, Jung Min; Spitzer, Matthew H.; Rubinshtein, Mark; Habib, Lila K.; Capule, Christina C.; Mayer, Michael; Turner, R. Scott; Kirkwood, Alfredo; Yang, Jerry; Pak, Daniel T. S.; Lee, Hey-Kyoung; Hoe, Hyang-Sook published an article.Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesis. And the article contained the following:

The tetra(ethylene glycol) derivative of benzothiazole aniline, BTA-EG4, is a novel amyloid-binding small mol. that can penetrate the blood-brain barrier and protect cells from Aβ-induced toxicity. However, the effects of Aβ-targeting mols. on other cellular processes, including those that modulate synaptic plasticity, remain unknown. We report here that BTA-EG4 decreases Aβ levels, alters cell surface expression of amyloid precursor protein (APP), and improves memory in wild-type mice. Interestingly, the BTA-EG4-mediated behavioral improvement is not correlated with LTP, but with increased spinogenesis. The higher dendritic spine d. reflects an increase in the number of functional synapses as determined by increased miniature EPSC (mEPSC) frequency without changes in presynaptic parameters or postsynaptic mEPSC amplitude. Addnl., BTA-EG4 requires APP to regulate dendritic spine d. through a Ras signaling-dependent mechanism. Thus, BTA-EG4 may provide broad therapeutic benefits for improving neuronal and cognitive function, and may have implications in neurodegenerative disease therapy. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to benzothiazole aniline tetraethylene glycol derivative ras protein spinogenesis neuroprotectant, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 4, 2005, Taniguchi, Sayuri; Suzuki, Nobuyuki; Masuda, Masami; Hisanaga, Shin-ichi; Iwatsubo, Takeshi; Goedert, Michel; Hasegawa, Masato published an article.Category: thiazole The title of the article was Inhibition of Heparin-induced Tau Filament Formation by Phenothiazines, Polyphenols, and Porphyrins. And the article contained the following:

Tau protein is the major component of the intraneuronal filamentous inclusions that constitute defining neuropathol. characteristics of Alzheimer’s disease and other tauopathies. The discovery of tau gene mutations in familial forms of frontotemporal dementia has established that dysfunction of the tau protein is sufficient to cause neurodegeneration and dementia. Here we have tested 42 compounds belonging to nine different chem. classes for their ability to inhibit heparin-induced assembly of tau into filaments in vitro. Several phenothiazines (methylene blue, azure A, azure B, and quinacrine mustard), polyphenols (myricetin, epicatechin 5-gallate, gossypetin, and 2,3,4,2′,4′-pentahydroxybenzophenone), and the porphyrin ferric deuteroporphyrin IX inhibited tau filament formation with IC50 values in the low micromolar range as assessed by thioflavin S fluorescence, electron microscopy, and Sarkosyl insolubility Disassembly of tau filaments was observed in the presence of the porphyrin phthalocyanine. Compounds that inhibited tau filament assembly were also found to inhibit the formation of Aβ fibrils. Biochem. anal. revealed the formation of soluble oligomeric tau in the presence of the inhibitory compounds, suggesting that this may be the mechanism by which tau filament formation is inhibited. The compounds investigated did not affect the ability of tau to interact with microtubules. Identification of small mol. inhibitors of heparin-induced assembly of tau will form a starting point for the development of mechanism-based therapies for the tauopathies. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Category: thiazole

The Article related to tau filament inhibition phenothiazine polyphenol porphyrin amyloid fibril, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 31, 2008, Ukrainets, I. V.; Tkach, A. A.; Grinevich, L. A. published an article.HPLC of Formula: 92-36-4 The title of the article was 4-Hydroxy-2-quinolones 148. Synthesis and antitubercular activity of 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid N-R-amides. And the article contained the following:

A method for the synthesis of the title compound [i.e., 1-hydroxy-3-oxo-6,7-dihydro-3H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid N-amides] is reported here. A reaction of 1,2,3,4-tetrahydroquinoline with methanetricarboxylic acid 1,1,1-tri-Et ester provided an ester compound [i.e., 2,3-dihydro-7-hydroxy-5-oxo-1H,5H-benzo[ij]quinolizine-6-carboxylic acid Et ester]. The above-mentioned amides were prepared from this intermediate by a reaction with primary amines. A comparative anal. has been carried out of the antitubercular activity of the compounds thus prepared with active structural analogs. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).HPLC of Formula: 92-36-4

The Article related to tuberculostatic hydroxy oxo benzoquinolizinecarboxamide preparation, antibacterial antimycobacterial agent hydroxy oxo benzoquinolizinecarboxamide preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.HPLC of Formula: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 15, 2005, Zhuravel’, Irina O.; Kovalenko, Sergiy M.; Ivachtchenko, Alexandre V.; Balakin, Konstantin V.; Kazmirchuk, Victor V. published an article.HPLC of Formula: 92-36-4 The title of the article was Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides. And the article contained the following:

Several 2-imino-5-hydroxymethyl-8-methyl-2H-pyrano[2,3-c]pyridine-3-(N-aryl)carboxamides, e.g., I, were prepared by reaction of pyridoxal hydrochloride with various N-aryl cyanoacetamides. Reaction of these compounds with aromatic amines furnished a wide series of 2-(N-R-phenyl) imino-5-hydroxymethyl-8-methyl-2H-pyrano[2,3-c]pyridine-3-carboxamides. Antibacterial and antifungal activities of the synthesized compounds were studied. Most of the obtained compounds demonstrated significant activity against bacterial or fungal strains (MIC in the range of 12.5-25 μg/mL), displaying comparable or even better efficacy than the standard drugs. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).HPLC of Formula: 92-36-4

The Article related to pyridoxal cyanoacetamide cyclization, iminopyranopyridinecarboxamide preparation arylamine arylation, arylimino pyranopyridinecarboxamide preparation antimicrobial, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.HPLC of Formula: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhuravel’, I. O.; Kovalenko, S. M.; Ivashchenko, A. V.; Chernykh, V. P. published an article in 2005, the title of the article was Construction of the combinatorial libraries of 5-hydroxymethyl-2-imino-8-methyl-2H-pyrano[2,3-c]pyridin-3-N-arylcarboxamides.SDS of cas: 92-36-4 And the article contains the following content:

Using the parallel solution-phase synthesis combinatorial libraries of 5-hydroxymethyl-2-imino-8-methyl-2H-pyrano[2,3-c]pyridin-3-N-arylcarboxamides, 5-hydroxymethyl-2-N-arylimino-methyl-2H-pyrano[2,3-c]pyridin-3-N-arylcarboxamides and their acyclic derivatives were obtained. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).SDS of cas: 92-36-4

The Article related to pyranopyridine preparation biol activity prediction, pyridoxal hydrochloride cyanoacetarylamide cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.SDS of cas: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nazarov, V. N.; Marchenko, Ya. S.; Taran, S. V.; Ignatenko, O. N. published an article in 2006, the title of the article was Acylation of amines by diphenic anhydride.Synthetic Route of 92-36-4 And the article contains the following content:

The acylation reaction of various aliphatic, aromatic and heterocyclic amines, hydrazines and hydrazides with diphenic anhydride has been investigated. The corresponding monoamides have been exclusively obtained. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Synthetic Route of 92-36-4

The Article related to amine hydrazine hydrazine primary acylation diphenic anhydride, amide carboxybiphenyl preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Synthetic Route of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Hussein, Awaz Jamil; Azeez, Hashim Jalal published an article in 2013, the title of the article was Synthesis and antimicrobial activity of some new thiazolidin-4-one derivatives of 4-(6-methylbenzo[d]thiazol-2-yl)benzamine.COA of Formula: C14H12N2S And the article contains the following content:

A number of derivatives of 2-(substituted phenyl)-3-(4-(6-methylbenzo[d]thiazol-2-yl)phenyl)thiazolidin-4-one were synthesized from the reaction of 4-(6-methylbenzo[d]thiazol-2-yl)benzenamine with different substituted benzaldehydes followed by cyclocondensation reaction of the prepared imines with 2-mercaptoacetic acid in high yields. Furthermore, the structures of the newly synthesized compounds were confirmed by FT-IR, 13C-NMR, 13C-DEPT, and 1H-NMR spectral data. The imines and thiazolidin-4-one derivatives were evaluated for their antibacterial activity against Escherichia coli as gram neg. and Staphylococcus aureus as gram pos., the results have shown significant activity against both types of bacteria. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).COA of Formula: C14H12N2S

The Article related to benzothiazolylaniline aryl aldehyde condensation, schiff base preparation antibacterial cyclization mercaptoacetate, aryl benzothiazolylphenyl thiazolidinone preparation antibacterial and other aspects.COA of Formula: C14H12N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 31, 2009, Yotnoi, Bunlawee; Limtrakul, Jumras; Prior, Timothy; Rujiwatra, Apinpus published an article.Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was Preparation and Characterization of Bis(μ-1,2-diaminoethane)cobalt(II) Hexavanadate: A Layered Polyoxovanadate Pillared by a Cobalt Coordination Complex. And the article contained the following:

The first example of polyoxovanadate layered framework with a cobalt coordination complex as a pillaring unit, CoII(μ-C2N2H8)2[VIV4VV2O14], was readily synthesized under hydrothermal conditions. The structure can be solved and refined in monoclinic P21/n with a 9.143(3), b 6.5034(11), c 15.874(4) Å, β = 101.90(2), V = 923.6(4) Å3 and Z = 2. The crystal structure comprises two-dimensional {VIV4VV2O14}2- layers extending parallel to [101], constructed from tetrahedral {VVO4} and square pyramidal {VIVO5} building units. Adjacent layers are linked through the octahedral {CoIIO2(μ-C2N2H8)2} pillars, within which the CoII resides on an inversion center. The structure displays N-H···O and C-H···O hydrogen bonding between the ethylenediamine and vanadium oxide layers. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to cobalt diaminoethane bridge layered polyoxovanadate pillared complex hydrothermal preparation, crystal structure cobalt diaminoethane bridge layered polyoxovanadate pillared complex and other aspects.Recommanded Product: 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 1, 2015, Maracic, Silvija; Kraljevic, Tatjana Gazivoda; Paljetak, Hana Cipcic; Peric, Mihaela; Matijasic, Mario; Verbanac, Donatella; Cetina, Mario; Raic-Malic, Silvana published an article.Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was 1,2,3-Triazole pharmacophore-based benzofused nitrogen/sulfur heterocycles with potential anti-Moraxella catarrhalis activity. And the article contained the following:

Versatile 1,2,3-triazole pharmacophore-based benzofused heterocycles containing halogen-substituted aromatic, 7-substituted coumarin or penciclovir-like subunit were designed and synthesized to evaluate their antibacterial activities against selected Gram-pos. and Gram-neg. bacteria. Hybridization approach using environmentally friendly Cu(I)-catalyzed click reaction under microwave irradiation was adopted in the synthesis of regioselective 1,4-disubstituted 1,2,3-triazole tethered heterocycles, while post-N-alkylation of NH-1,2,3-triazoles afforded both 2,4- and 1,4-disubstituted 1,2,3-triazole regioisomers. Several compounds revealed fluorescence in the violet region of the visible spectrum with a strong influence of Ph spacer in 25-30 on both wavelength and emission intensity. Fusion of selected subunits led to new hybrid architecture, benzothiazole-1,2,3-triazolecoumarin derivative I that demonstrated extremely narrow spectrum activity towards fastidious Gram-neg. bacteria Moraxella catarrhalis. Selected hybrids showed the potency against Moraxella catarrhalis (MIC ≤ 0.25 μg/mL) comparable to that of reference antibiotic azithromycin, which suggested that further investigations are necessary to optimize this potential hit compound as a new anti-Moraxella catarrhalis agent. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to moraxella catarrhalis antibacterial triazole heterocycle preparation, 1,2,3-triazole, antibacterial activity, coumarin, fluorescence, hybridization approach, moraxella catarrhalis and other aspects.Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 31, 2020, Goya-Jorge, Elizabeth; Giner, Rosa M.; Sylla-Iyarreta Veitia, Maite; Gozalbes, Rafael; Barigye, Stephen J. published an article.Electric Literature of 92-36-4 The title of the article was Predictive modeling of aryl hydrocarbon receptor (AhR) agonism. And the article contained the following:

The aryl hydrocarbon receptor (AhR) plays a key role in the regulation of gene expression in metabolic machinery and detoxification systems. In the recent years, this receptor has attracted interest as a therapeutic target for immunol., oncogenic and inflammatory conditions. In the present report, in silico and in vitro approaches were combined to study the activation of the AhR. To this end, a large database of chem. compounds with known AhR agonistic activity was employed to build 5 classifiers based on the Adaboost (AdB), Gradient Boosting (GB), Random Forest (RF), Multilayer Perceptron (MLP) and Support Vector Machine (SVM) algorithms, resp. The built classifiers were examined, following a 10-fold external validation procedure, demonstrating adequate robustness and predictivity. These models were integrated into a majority vote based ensemble, subsequently used to screen an inhouse library of compounds from which 40 compounds were selected for prospective in vitro exptl. validation. The general correspondence between the ensemble predictions and the in vitro results suggests that the constructed ensemble may be useful in predicting the AhR agonistic activity, both in a toxicol. and pharmacol. context. A preliminary structure-activity anal. of the evaluated compounds revealed that all structures bearing a benzothiazole moiety induced AhR expression while diverse activity profiles were exhibited by phenolic derivatives The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Electric Literature of 92-36-4

The Article related to aryl hydrocarbon receptor agonism benzothiazole b hesperetin apigenin, agonistic activity, aryl hydrocarbon receptor, benzothiazoles, computational modeling, coumarins, flavonoids, polyphenols, qsar, triterpenes and other aspects.Electric Literature of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica